Joseph Ssekasanvu
A5014426318- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- HIV/AIDS Impact and Responses
- Genital Health and Disease
- Female Genital Mutilation/Cutting Issues
- Sex work and related issues
- Urologic and reproductive health conditions
- Intimate Partner and Family Violence
- Cervical Cancer and HPV Research
- Traumatic Ocular and Foreign Body Injuries
- COVID-19 epidemiological studies
- Mobile Health and mHealth Applications
- COVID-19 Digital Contact Tracing
- Global Cancer Incidence and Screening
- Glaucoma and retinal disorders
- Reproductive tract infections research
- Global Public Health Policies and Epidemiology
- Retinal Diseases and Treatments
- Data-Driven Disease Surveillance
- HIV/AIDS drug development and treatment
- Sinusitis and nasal conditions
- Research Data Management Practices
- Data Quality and Management
Rakai Health Sciences Program
2015-2024
Johns Hopkins University
2012-2024
Johns Hopkins Medicine
2021
Uganda Virus Research Institute
2006-2017
Makerere University
2012-2016
October 6 University
2016
Intimate partner violence (IPV) is associated with HIV infection. We aimed to assess whether provision of a combination IPV prevention and services would reduce incidence in individuals enrolled the Rakai Community Cohort Study (RCCS), Rakai, Uganda.We used pre-existing clusters communities randomised as part previous family planning trial this cohort. Four intervention group from were provided standard care plus community-level mobilisation change attitudes, social norms, behaviours related...
The COVID-19 pandemic has sparked unprecedented public health and social measures (PHSM) by national local governments, including border restrictions, school closures, mandatory facemask use stay at home orders. Quantifying the effectiveness of these interventions in reducing disease transmission is key to rational policy making response current future pandemics. In order estimate interventions, detailed descriptions their timelines, scale scope are needed. Health Intervention Tracking for...
BackgroundInternational and global organisations advocate targeting interventions to areas of high HIV prevalence (ie, hotspots). To better understand the potential benefits geo-targeted control, we assessed extent which hotspots along Lake Victoria sustain transmission in neighbouring populations south-central Uganda.MethodsWe did a population-based survey Rakai, Uganda, using data from Rakai Community Cohort Study. The study surveyed all individuals aged 15–49 years four high-prevalence...
Abstract To prevent new infections with human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa, UNAIDS recommends targeting interventions to populations that are at high risk of acquiring and passing on the virus. Yet it is often unclear who where these ‘source’ are. Here we demonstrate how viral deep-sequencing can be used reconstruct HIV-1 transmission networks infer direction networks. We able deep-sequence from a large population-based sample infected individuals Rakai...
Abstract HIV prevalence varies markedly throughout Africa, and it is often presumed areas of higher (i.e., hotspots) serve as sources infection to neighboring lower prevalence. However, the small-scale geography migration networks movement HIV-positive individuals between communities poorly understood. Here, we use population-based data from ~22,000 persons known status characterize migratory patterns their relationship among 38 in Rakai, Uganda with ranging 9 43%. We find that migrants...
The foreskin is a site of heterosexual acquisition HIV-1 among uncircumcised men. However, some men remain HIV-negative despite repeated, unprotected vaginal intercourse with HIV-positive partners, while others become infected after few exposures. microbiome includes diverse group anaerobic bacteria that have been linked to HIV acquisition. these anaerobes tend coassociate, making it difficult determine which species might increase risk and may be innocent bystanders. Here, we show 6...
The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical in women from rural Rakai District, Uganda.Between 2002 2003, a population-based cohort participated an HPV study. Women collected were also offered pelvic examination, which included physician-collected samples.Hybrid-capture 2 used determine carcinogenic status. Polymerase chain reaction genotypes. Unweighted kappa statistics...
Intimate partner violence (IPV), HIV and sexually transmitted infections (STI) can contribute to disparities in population health, depending on the individual, social environmental factors characterizing a setting. To better understand place-based determinants patterns of these key interrelated public health problems Uganda, we compared risk for IPV, STI fishing, trading agrarian communities Rakai, Uganda by gender. This study used cross-sectional data collected from 14,464 active men (n =...
Abstract Background: We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda. Methods: Women provided swab at annual home-based visits. Type-specific HPV risk factors were assessed. Results: Carcinogenic was 17.3 per 100 person-years among HIV-positive women compared with 7.0 HIV-negative (P < 0.001). HPV-51 had highest followed by HPV-16 (1.8 1.5 person-years, respectively). In...
<h3>Importance</h3> Medical male circumcision (MMC) and antiretroviral therapy (ART) are proven HIV prevention interventions, but there limited data on the population-level effect of scale-up these interventions in sub-Saharan Africa. Such evaluation is important for planning resource allocation. <h3>Objective</h3> To examine whether increasing community MMC ART coverage was associated with reduced incidence Rakai District, Uganda. <h3>Design, Setting, Participants</h3> Using person-level...
Abstract Introduction : To assess progress towards the UNAIDS 90–90–90 initiative targets, we examined HIV care cascade in population‐based Rakai Community Cohort Study (RCCS) rural Uganda and differences between sub‐groups. Methods Self‐reports clinical records were used to proportion achieving each stage cascade. Statistical inference based on a χ 2 test for categorical variables modified Poisson regression estimate prevalence risk ratios (PRRs) 95% confidence intervals (CI) enrolment into...
Abstract HIV incidence in eastern and southern Africa has historically been concentrated among girls women aged 15–24 years. As new cases decline with interventions, population-level infection dynamics may shift by age gender. Here, we integrated population-based surveillance of 38,749 participants the Rakai Community Cohort Study longitudinal deep-sequence viral phylogenetics to assess how population groups driving transmission have changed from 2003 2018 Uganda. We observed 1,117...
ABSTRACT Background There are limited population-level data on the pre-exposure prophylaxis (PrEP) care continuum in eastern Africa. Here, we assessed PrEP following rollout a Ugandan community with ∼40% HIV seroprevalence. Methods We used cross-sectional population-based collected between September 3 and December 19, 2018 from Lake Victoria fishing southern Uganda to measure levels of self-reported knowledge, ever use, discontinuation 2017 via U.S. President’s Emergency Plan for AIDS Relief...
There are limited data on individual human immunodeficiency virus (HIV) viral load (VL) trajectories at the population-level after introduction of universal test and treat (UTT) in sub-Saharan Africa.
Abstract HIV incidence in eastern and southern Africa has historically been concentrated among girls women aged 15-24 years. As new cases decline with interventions, population-level infection dynamics may shift by age gender. Here, we integrated population-based surveillance of 38,749 participants the Rakai Community Cohort Study longitudinal deep sequence viral phylogenetics to assess how population groups driving transmission have changed from 2003 2018 Uganda. We observed 1,117...
Background Effective implementation strategies are needed to increase engagement in HIV services hyperendemic settings. We conducted a pragmatic cluster-randomized trial high-risk, highly mobile fishing community (HIV prevalence: approximately 38%) Rakai, Uganda, assess the impact of health worker-delivered, theory-based (situated Information, Motivation, and Behavior Skills), motivational interviewing-informed, phone application-supported counseling strategy called “Health Scouts” promote...
<strong>Background:</strong> Limited studies exploring the impact of socioeconomic status (SES) on hypertension in Africa suggest a positive association between higher SES and hypertension. The economic development sub-Saharan African countries has led to changes associated lifestyle, diet, physical activity, which may affect relationship differently compared with income countries. This cross-sectional study from large population-based cohort, Rakai Community Cohort Study (RCCS), examines...
Despite efforts to promote HIV counseling and testing (HCT) among couples, few couples know their own or partners' status. We assessed trends in HCT uptake married individuals Rakai district, southwestern Uganda. analysed data for 21,798 aged 15-49 years who were enrolled into the Community Cohort Study (RCCS) between 2003 2009. Married interviewed separately but retrospectively linked partners at analysis. All participants had serologic samples obtained testing, option of receiving together...
The efficacy of voluntary male medical circumcision (VMMC) for human immunodeficiency virus (HIV) prevention in men was demonstrated 3 randomized trials. This led to the adoption VMMC as an integral component United States President's Emergency Plan AIDS Relief (PEPFAR) combination HIV program sub-Saharan Africa. However, evidence on individual-level effectiveness programs real-world, programmatic settings is limited.
Abstract HIV incidence in eastern and southern Africa has historically been concentrated among girls women aged 15-24 years, but as new cases decline with interventions, population-level infection dynamics may shift by age gender. Here, we integrated population-based surveillance longitudinal deep- sequence viral phylogenetics to assess how the population groups driving transmission have evolved over a 15-year period from 2003 2018 Uganda. suppression increased more rapidly than men,...
To assess geospatial patterns of HIV antiretroviral therapy (ART) treatment facility use and whether they were impacted by viral load suppression.We extracted data on the location type care services utilized HIV-positive persons accessing ART between February 2015 September 2016 from Rakai Community Cohort Study in Uganda. The distance households to facilities offering was calculated using open street map road network. Modified Poisson regression used identify predictors traveled and, for...