A5073843147- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Prostate Cancer Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- Amyotrophic Lateral Sclerosis Research
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- Intensive Care Unit Cognitive Disorders
- Parkinson's Disease Mechanisms and Treatments
- Music Therapy and Health
- COVID-19 and Mental Health
- Prostate Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Obesity, Physical Activity, Diet
- Food Security and Health in Diverse Populations
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Primary Care and Health Outcomes
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Renal and related cancers
- Mental Health and Patient Involvement
- Health Policy Implementation Science
Optum (United States)
2021-2023
University of Pittsburgh
2023
UnitedHealth Group (United States)
2021
Patient-Centered Outcomes Research Institute
2014-2020
Indiana University – Purdue University Indianapolis
2018
National Institutes of Health
2007-2014
National Cancer Institute
2005-2014
Division of Cancer Epidemiology and Genetics
2005-2014
United States Department of Health and Human Services
2012-2013
AARP
2011
To evaluate the excess risk and relative hazards for developing incident clinical sequelae after acute phase of SARS-CoV-2 infection in adults aged 18-65.Retrospective cohort study.Three merged data sources from a large United States health plan: national administrative claims database, an outpatient laboratory testing inpatient hospital admissions database.Individuals 18-65 with continuous enrollment plan January 2019 to date diagnosis infection. Three comparator groups, matched by...
To provide an overview of PCORI’s approach to engagement in research. The Patient-Centered Outcomes Research Institute (PCORI) was established 2010 fund patient-centered comparative effectiveness Requirements for research funding from PCORI include meaningful patients and other stakeholders the is guided by a conceptual model outcomes (PCOR), that provides structure understanding understand improve learning awardees stakeholders. Those efforts are described along with capacity building...
Abstract Objective To characterize the risk of persistent and new clinical sequelae in adults aged ≥65 years after acute phase SARS-CoV-2 infection. Design Retrospective cohort study. Setting UnitedHealth Group Clinical Research Database: deidentified administrative claims outpatient laboratory test results. Participants Individuals who were continuously enrolled a Medicare Advantage plan with coverage prescription drugs from January 2019 to date diagnosis infection, matched by propensity...
Abstract Chronic intraprostatic inflammation is suspected to play a role in the pathogenesis of prostate cancer. Polymorphisms cytokine genes can influence and immune response may be related risk Four common single nucleotide polymorphisms (SNPs) encoding interleukin-1B (IL-1B), IL-6, IL-8 were assessed 503 cancer cases 652 controls, three SNPs IL-10 an additional 817 1,190 controls (for total 1,320 1,255 controls). Cases selected from on-going Prostate, Lung, Colorectal Ovarian Cancer...
<h3>Importance</h3> Determining the right dosage of aspirin for secondary prevention treatment atherosclerotic cardiovascular disease (ASCVD) remains an unanswered and critical question. <h3>Objective</h3> To report rationale design a randomized clinical trial to determine optimal be used ASCVD, using innovative research method. <h3>Design, Setting, Participants</h3> This pragmatic, open-label, patient-centered, is being conducted in 15 000 patients within National Patient-Centered Clinical...
The Patient-Centered Outcomes Research Institute (PCORI) recently launched PCORnet to establish a single inter-operable multicenter data research network that will support observational and randomized clinical trials. This paper provides an overview of the patient-powered networks (PPRNs), patient organizations focused on particular health condition are interested in sharing information engaging research. PPRNs build their foundation trust within communities draw expertise, working with...
The incidence of bladder cancer among women is at least one-third to one-fourth that observed men in many countries. Even after accounting for known risk factors, the reason this gender disparity remains unexplained. We conducted a comprehensive evaluation reproductive factors and exogenous hormone use with primary focus on menopausal therapy NIH-AARP Diet Health Study. Reproductive hormonal were ascertained baseline questionnaire 1995-1996 201,492 females who followed until December 31,...
Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men prostate cancer. Germline variants in gene that encodes PSA (KLK3) have been shown be associated with both and Based on resequencing analysis 56 kb region chromosome 19q13.33, centered KLK3 gene, we fine mapped this locus by genotyping tag SNPs 3,522 cancer cases 3,338 controls from five case-control studies. We did not observe strong association variant, reported previous...
Although epidemiologic studies have examined the risk of amyotrophic lateral sclerosis (ALS) in relation to cancer, none been large population‐based using incident ALS and adjusting for medical surveillance. Addressing those limitations, all first primary cancer cases from Surveillance, Epidemiology End Results (SEER) Program (1992–2005), linked Medicare claims data were used. Cases followed diagnosis until earliest date diagnosis, a break data, death, age 85 or December 31, 2005. A...
Renal cell carcinomas (RCC) are responsible for the deaths of 3% to 4% patients with ESRD. The clear carcinoma kidney, which comprises 80% sporadic RCC within general population, shows a deletion gene sequences in short arm chromosome 3 (3p) as many 100% cases. von Hippel-Lindau tumor suppressor at 3p25-26 is found be mutated nondeleted allele 57% these carcinomas. This study was undertaken determine histopathologic types occurring ESRD United States and investigate frequency 3p genetic...
Abstract Genetic anticipation in familial non–Hodgkin's lymphoma, Hodgkin's and chronic lymphocytic leukemia (CLL) has been consistently reported the literature. However, most of these findings were based on data from families ascertained for genetic studies. Fecundity bias, right censoring secular trends can lead to erroneous conclusions regarding presence anticipation. Our report investigates four lymphoproliferative cancers, CLL, multiple myeloma, drawn Swedish Danish population-based...
Clinical and experimental findings suggest that female hormonal reproductive factors could influence kidney cancer development. To evaluate this association, we conducted analyses in 2 large prospective cohorts (the National Institutes of Health-AARP Diet Health Study (NIH-AARP), 1995-2006, the Prostate, Lung, Colorectal Ovarian Cancer Screening Trial (PLCO), 1993-2010). Cohort-specific aggregated hazard ratios 95% confidence intervals relating risk were computed by Cox regression. The...
Several case-control studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce risk for glioblastoma, an aggressive form of brain cancer. Prospective investigations not observed such association, but these lacked adequate cancer case numbers and did stratify by histologic subtype. We prospectively investigated the association between NSAID use all glioma as well glioblastoma subtype in National Institutes Health (NIH)-AARP Diet Study. The frequency aspirin nonaspirin 1...
Recent epidemiological studies suggest that alcohol consumption may reduce renal cell carcinoma (RCC) risk, although inconsistent findings have been reported by sex and alcoholic beverage type. To better understand the relationship between RCC we conducted an analysis within Prostate, Lung, Colorectal Ovarian Cancer Screening Trial. We followed up participants in analytic cohort (N = 107,998) through 2010 for incident 408), computed hazard ratios (HRs) 95% confidence intervals (CIs) intake...
Objectives and Methods: Using pooled multivariable-adjusted rate ratios (RR), we explored relationships between prediagnostic body-mass-index (BMI), waist-to-hip-ratio (WHR), weight-gain during adulthood, ALS in 419,894 women 148,166 men from 10 community-based cohorts USA, Europe, Australia; 428 deaths were documented 204 men. Results: Higher mid-to-later adulthood BMI was associated with lower mortality. For 5 kg/m2 increased BMI, the 15% (95% confidence interval [CI]: 4–24%; p = 0.005)....
Abstract Objective Clinical sequelae have not been well characterized during the post-acute phase of SARS-CoV-2 among adults 18 to 65 years old, and this study sought fill that gap by evaluating excess risk relative hazards for developing incident clinical phase. Design Retrospective cohort including three propensity-matched groups. Setting This merged data sources from a large United States health plan: national administrative claims database, an outpatient lab testing inpatient hospital...
Prostate cancer is one of the leading causes cancer-related death in U.S. men. There an unmet need to identify modifiable risk factors for prostate survival. Experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may improve survival through antithrombotic and anti-inflammation mechanisms. Results from previous observational been equivocal, few assessed whether etiologically relevant time window exposure exists. We sampled incident cases two large prospective...
We use data on lymphoma in families of Hodgkin (HL) cases from the Swedish Family Cancer Database (Hemminki et al. 2001) to illustrate survival methods for detecting familial aggregation first degree relatives case probands compared control probands, registries that permit sampling all cases. Because more than one may occur a given family, are not necessarily independent, and we present procedures allow such dependence. A bootstrap procedure also accommodates matching by resampling clusters,...
Abstract BACKGROUND The Gln allele of the Arg462Gln polymorphism in RNASEL results a threefold decrease enzymatic activity, reported deficiency apoptotic response, and has been associated with prostate cancer some high‐risk family studies. relationship this variant to sporadic remains uncertain. METHODS We conducted nested case‐control study 1,317 cases 1,842 controls from screening arm prostate, lung, colorectal, ovarian (PLCO) trial. Conditional logistic regression was used evaluate...
To explore whether monoclonal antibodies (MAb) administered to high-risk patients with COVID-19 during the first week of illness prevent postacute sequelae SARS-CoV-2 infection.Retrospective cohort study.USA.A sample 3809 individuals who received MAbs and a matched one-to-one comparison group from set 327 079 eligible did not receive MAb treatment were selected deidentified administrative data commercial Medicare Advantage health plan enrollees in USA, including claims outpatient laboratory...