A5078885759- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Inflammatory mediators and NSAID effects
- Metabolism, Diabetes, and Cancer
Université de Montréal
2016-2025
Montreal Heart Institute
2016-2025
Clinical Research Institute
2018-2025
Duke Medical Center
2019-2025
Duke University
2018-2024
Duke University Health System
2023
University of California, San Francisco
2023
Polytechnique Montréal
2023
University of Ottawa
2023
Duke University Hospital
2022
The appropriate dose of aspirin to lower the risk death, myocardial infarction, and stroke minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject controversy.Using an open-label, pragmatic design, we randomly assigned strategy 81 mg or 325 per day. primary effectiveness outcome was composite death from any cause, hospitalization for stroke, assessed time-to-event analysis. safety bleeding, also analysis.A total 15,076 were followed median...
Stroke remains a devastating complication of transcatheter aortic valve replacement (TAVR), which has persisted despite refinements in technique and increased operator experience. While cerebral embolic protection devices (EPDs) have been developed to mitigate this risk, data regarding their impact on stroke other outcomes after TAVR are limited.
As a result of the widespread use reperfusion therapies and secondary prevention over last 30 years, there has been dramatic reduction in risk mortality development heart failure (HF) following acute myocardial infarction (MI). Despite this, chronic HF remains common occurrence days, months, years MI. Neurohormonal inhibition mainstay pharmacologic MI, with recent trials showing an additive benefit neprilysin inhibitor or sodium glucose co-transporter 2 reducing but no significant effect on...
Abstract The coronary angiogram is the gold standard for evaluating severity of artery disease stenoses. Presently, assessment conducted visually by cardiologists, a method that lacks standardization. This study introduces DeepCoro, ground-breaking AI-driven pipeline integrates advanced vessel tracking and video-based Swin3D model was trained validated on dataset comprised 182,418 angiography videos spanning 5 years. DeepCoro achieved notable precision 71.89% in identifying segments...
<h3>Importance</h3> Determining the right dosage of aspirin for secondary prevention treatment atherosclerotic cardiovascular disease (ASCVD) remains an unanswered and critical question. <h3>Objective</h3> To report rationale design a randomized clinical trial to determine optimal be used ASCVD, using innovative research method. <h3>Design, Setting, Participants</h3> This pragmatic, open-label, patient-centered, is being conducted in 15 000 patients within National Patient-Centered Clinical...
BACKGROUND: Coronary artery bypass grafting (CABG) is the recommended mode of revascularization in patients with ischemic left ventricular dysfunction (iLVSD) and multivessel disease. However, contemporary percutaneous coronary intervention (PCI) outcomes have improved integration novel technologies refinement strategies, PCI often used clinical practice this population. There a lack evidence from randomized trials comparing state-of-the-art versus CABG for treatment iLVSD This was impetus...
Objectives The objective was to assess the effect of ultrasound (US)‐guidance compared anatomical landmark (AL) approach in patients requiring femoral artery (FA) access for coronary angiography/percutaneous interventions (PCI). Background US‐guidance has been proposed as a strategy optimize FA access, potentially leading decreased vascular complications. Methods Patients angiography/PCI were randomized US‐guided or AL approaches. primary endpoint composite immediate procedural outcomes, and...
Mechanical circulatory support (MCS) devices can be used in high-risk percutaneous coronary intervention (PCI). Our objective was to describe trends and outcomes of prophylactic MCS use elective PCI for patients with stable artery disease the American College Cardiology National Cardiovascular Data Registry's CathPCI registry.Among 2 108 715 consecutive undergoing registry between 2009 2018, we examined patterns MCS. Propensity score models inverse probability treatment weighting compared...
Large outcome trials have demonstrated cardiovascular benefits of selected glucagon-like peptide-1 (GLP-1) receptor agonists. We examined coronary disease outcomes in the Harmony Outcomes trial GLP-1 agonist albiglutide.
Acute coronary syndromes (ACS), encompassing conditions like ST-elevation myocardial infarction (STEMI) and non-ST-elevation acute (NSTE-ACS), represent a significant challenge in cardiovascular care due to their complex pathophysiology substantial impact on morbidity mortality. The 2023 European Society of Cardiology (ESC) guidelines for ACS management introduce several updates key areas such as invasive treatment timing NSTE-ACS, pre-treatment strategies, approaches multivessel disease,...
In the Surgical Treatment for Ischaemic Heart Failure Trial Extension Study (STICHES), coronary artery bypass grafting (CABG) improved outcomes of patients with ischaemic left ventricular dysfunction receiving medical therapy, whereas in Revascularization Ischaemia Ventricular Dysfunction trial (REVIVED-BCIS2), percutaneous intervention (PCI) did not. The aim this study was to explore differences participants treated therapy alone STICHES vs. REVIVED-BCIS2 and assess incremental benefit CABG...