A5101401798- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Railway Systems and Energy Efficiency
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- Electrical Contact Performance and Analysis
- Electric and Hybrid Vehicle Technologies
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Cancer Immunotherapy and Biomarkers
- HVDC Systems and Fault Protection
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- IL-33, ST2, and ILC Pathways
- High-Voltage Power Transmission Systems
- Power Systems and Renewable Energy
- ATP Synthase and ATPases Research
- SARS-CoV-2 and COVID-19 Research
- Power Systems Fault Detection
Shandong Center for Disease Control and Prevention
2016-2025
Huazhong University of Science and Technology
2012-2024
Foshan University
2024
Northwestern Polytechnical University
2024
Second Xiangya Hospital of Central South University
2020-2023
Central South University
2019-2023
Nanchang University
2016-2023
Hunan Agricultural University
2023
First Affiliated Hospital of Nanchang University
2023
Southwest Jiaotong University
2023
Significance Although the overwhelming majority of COVID-19-related deaths are due to respiratory failure, little is known about host response SARS-CoV-2 in lung parenchyma. By profiling and colon transcriptome proteome nine patients who died COVID-19 during first wave pandemic Wuhan, China, we obtained molecular insights into severe infection. Interestingly, all samples had a low viral burden, finding that suggests patients’ may be uncontrolled inflammatory processes rather than an active...
Abstract Background The remodeling patterns in different types of chronic rhinosinusitis ( CRS ) have rarely been compared, particularly the difference between eosinophilic and noneosinophilic with nasal polyps w NP ). Moreover, whether there is a link inflammation remains controversial. Objective To directly compare features to explore their relationship C hinese patients. Methods Histologic characteristics surgical samples were analyzed 33 controls, 72 76 , without s Tissue from 38 26 32...
Although eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit distinct T-helper (Th) responses, the underlying mechanisms remain unclear.To clarify phenotypes Th-cell polarizing functions of dendritic cells (DCs) in different types CRSwNP.DC subsets, their surface phenotypes, subsets were studied by means immunohistochemistry flow cytometry. The sorted lesional DCs activated or cultured autologous naive CD4(+) T cells, cytokine production was determined...
Viral infections can alter host transcriptomes by manipulating splicing machinery. Despite intensive transcriptomic studies on SARS-CoV-2, a systematic analysis of alternative (AS) in severe COVID-19 patients remains largely elusive. Here we integrated proteomic and sequencing data to study AS changes patients. We discovered that RNA is among the major down-regulated signatures The transcriptome showed SARS-CoV-2 infection induces widespread dysregulation transcript usage expression,...
Chronic rejection that leads to diffuse narrowing and occlusion of graft vessels is the most important cause morbidity mortality following cardiac transplantation. The role underlying mechanism high-mobility group box 1 (HMGB1), as an established inflammatory mediator in acute rejection, remains poorly understood chronic rejection. Here, we assessed effects mechanisms HMGB1 on using single MHC Class II-mismatched mouse transplantation model. It was found increased accompanying with...
According to mounting evidence, long noncoding RNAs (lncRNAs) play a vital role in regulated cell death (RCD). A potential strategy for cancer therapy involves triggering ferroptosis, novel form of RCD. Although it is thought be an autophagy-dependent process, still unclear how the two processes interact. This study characterized intergenic RNA, LINC00551, expressed at low level lung adenocarcinoma (LUAD) and some other cancers. Overexpression LINC00551 suppresses viability while promoting...
From July 23, 2018, to December 31, 2019, a total of 299 219 children in Shandong Province received the fifth dose diphtheria, tetanus, and acellular pertussis combined vaccine (DTaP). Among these recipients, distribution by age was as follows: 20 under 2 years old (0.01%), 273 996 aged (91.57%), 242 3 (6.76%), 932 4 (1.31%), 963 5 (0.32%), 66 6 above (0.02%). In total, 1 972 cases adverse events following immunization (AEFI) were reported after administration DTaP, resulting an incidence...
Caenorhabditis elegans is a widely used model organism in biomedical research due to its genetic tractability, short life cycle, and conservation of many developmental processes with humans. In this study, undergraduate students conducted nine independent experiments during Developmental Biology course human phenotypes using C. elegans. Each group selected phenotype interest, identified gene associated the phenotype, then determined orthologous or homologous By obtaining mutants designing...
Aberrant N6-methyladenosine (m6A) RNA methylation regulatory genes and related gene alternative splicing (AS) could be used to predict the prognosis of non–small cell lung carcinoma. This study focused on 13 m6A (METTL3, METTL14, WTAP, KIAA1429, RBM15, ZC3H13, YTHDC1, YTHDC2, YTHDF1, YTHDF2, HNRNPC, FTO, ALKBH5) expression profiles in TCGA-LUAD ( n = 504) TCGA-LUSC 479) datasets from Cancer Genome Atlas database. The data were downloaded bioinformatically statistically analyzed, including...
RAD51 participates in homologous recombination (HR) repair of double-stranded DNA breaks (DSBs) that may cause genomic instability and cancer. Two single-nucleotide polymorphisms (SNPs) three P53 binding sites have been found the promoter 5' untranslated region. We hypothesized SNPs interact alter risk squamous cell carcinoma head neck (SCCHN) we genotyped for 135G>C 172G>T Arg72Pro 716 SCCHN patients 719 matched controls (all non-Hispanic whites) evaluated their effects on gamma...
Summary Severe acute respiratory syndrome (SARS), caused by infection with a novel coronavirus (SARS‐CoV), was the first major infectious disease at beginning of 21st century, China especially affected. SARS characterized high infectivity, morbidity and mortality, confined pattern spreading among countries South‐East East Asia suggested existence susceptible factor(s) in these populations. Studies populations Hong Kong Taiwan showed an association human leucocyte antigen (HLA) polymorphisms...
Abstract Pancreatic cancer is a lethal malignancy with an extremely poor prognosis. Although many genes and noncoding RNAs have been found to regulate its progression, more regulators are needed be understood resolve high lethality. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) plays crucial roles in the progression of various tumors, but role pancreatic has not studied. In this study, we that ERO1L was significantly upregulated cells patients; overexpression promoted migration,...
Mannose-binding lectin (MBL) is an important complement-activating protein of the human immune system. As a result one three structural gene mutations in exon 1 (variants B, C and D) and/or presence low-efficiency promoter polymorphism, MBL deficiency may be associated with increased susceptibility to infectious diseases autoimmune disorders, including systemic lupus erythematosus (SLE). Using combined approach heteroduplex generator polymerase chain reaction, systematic search for region...
It is well known that tumor necrosis factor-related apoptosis inducing ligand receptor 1 or 2 (DR4/DR5) specifically expressed in various cells, but less no expression most normal cells.Many first generations of TRAIL agonists including recombinant preparations TRAIL, agonistic antibodies against DR4/DR5 have been developed phase I/II clinical trials for cancer therapy.However, the outcomes by using agonist mono-therapy were disappointed even though safety profile was tolerance.In present...