A5062314473- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Neonatal Respiratory Health Research
- Nasolacrimal Duct Obstruction Treatments
- Neonatal and fetal brain pathology
- Traumatic Ocular and Foreign Body Injuries
- Cerebral Venous Sinus Thrombosis
- Vestibular and auditory disorders
- Retinal Imaging and Analysis
- Visual perception and processing mechanisms
- History of Medicine Studies
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Facial Trauma and Fracture Management
- Glioma Diagnosis and Treatment
- AI in cancer detection
- Ocular Infections and Treatments
- Child Abuse and Related Trauma
- Ocular Surface and Contact Lens
- Neonatal Health and Biochemistry
Case Western Reserve University
2016-2025
University School
2018-2025
University Hospitals of Cleveland
2015-2025
Rainbow Babies & Children's Hospital
2014-2025
Southern California Eye Institute
2023
University of Southern California
2023
University Hospitals Cleveland Medical Center
2011-2023
Ohio State University Hospital
2020
Indiana University – Purdue University Indianapolis
2001-2014
University Medical Center
2014
Glaucoma-related adverse events constitute major sight-threatening complications of cataract removal in infancy, yet their relationship to aphakia vs primary intraocular lens (IOL) implantation remains unsettled.To identify and characterize cases glaucoma glaucoma-related (glaucoma + suspect) among children the Infant Aphakia Treatment Study by age 5 years.A multicenter randomized clinical trial 114 infants with unilateral congenital referral centers who were between ages 1 6 months at...
Importance Glaucoma can develop following cataract removal in children. Objective To assess the cumulative incidence of glaucoma-related adverse events (defined as glaucoma or suspect) and factors associated with risk these first 5 years after lensectomy prior to 13 age. Design, Setting, Participants This cohort study used longitudinal registry data collected at enrollment annually for from 45 institutional 16 community sites. were children aged 12 younger least 1 office visit June 2012 July...
Injectable biomaterials play a vital role in modern medicine, offering tailored functionalities for diverse therapeutic and diagnostic applications. In ophthalmology, instance, viscoelastic materials are crucial procedures such as cataract surgery but often leave residues, increasing postoperative risks. This study introduces injectable fluorescent viscoelastics (FluoVs) synthesized via one-step controlled radical copolymerization of oligo(ethylene glycol) acrylate fluorescein acrylate....
ABSTRACT Elevated intraocular pressure (IOP) during glaucoma is sometimes mitigated by insertion of drainage devices (GDD). Excessive fibrosis around GDD plates may confine and requiring revision surgeries in some patients. Pirfenidone (PFD) an FDA approved drug to treat lung fibrosis, it be effective limiting capsule formation the GDD. To enable this, we aimed develop a polymeric encasement sheath that can sustainably release PFD reduce fibrous formation. The PFD‐doped was manufactured blow...
<h3>Importance</h3> Cataract is an important cause of visual impairment in children. Data from a large pediatric cataract surgery registry can provide real-world estimates outcomes and the 5-year cumulative incidence adverse events. <h3>Objective</h3> To assess acuity (VA), complications additional eye operations, refractive error 5 years after lensectomy among children younger than 13 years. <h3>Design, Setting, Participants</h3> This prospective cohort study used data Pediatric Eye Disease...
<h3>Importance</h3> Previous studies of<i>myo</i>-inositol in preterm infants with respiratory distress found reduced severity of retinopathy prematurity (ROP) and less frequent ROP, death, intraventricular hemorrhage. However, no large trials have tested its efficacy or safety. <h3>Objective</h3> To test the adverse events to reduce type 1 ROP among younger than 28 weeks' gestational age. <h3>Design, Setting, Participants</h3> Randomized clinical trial included 638 age enrolled from 18...
Glaucoma can occur following cataract removal in children, and determining the risk for factors associated with glaucoma suspect a large cohort of children after lensectomy guide clinical practice.To estimate incidence describe its management first year before 13 years age.A multicenter research registry containing data 1361 eyes 994 who underwent unilateral or bilateral between June 2012 July 2015 at 1 61 sites United States (n = 57), Canada 3), Kingdom 1). Patients were eligible inclusion...
Purpose To assess the agreement among ocular response analyzer (ORA), dynamic contour tonometry (DCT), Goldmann applanation (GAT), and noncontact (NCT), to determine effects of central corneal thickness (CCT) hysteresis (CH) on intraocular pressure (IOP) measurements with these devices. Methods Sixty healthy volunteers were recruited. The average ORA (corneal compensated IOP [IOP-ORAcc] Goldmann-correlated [IOP-ORAg]), DCT, GAT, NCT levels compared devices examined respect CCT CH. One-way...
Purpose: Ultrasound biomicroscopy (UBM) is an important ophthalmic imaging modality due to its ability see behind pigmented iris and visualize anterior chamber when the eye's transparency compromised. We created a three-dimensional UBM (3D-UBM) system acquired example images illustrate potential. Methods: A commercial 50-MHz two-dimensional (2D-UBM) was attached precision translation stage translated across eye acquire image volume. The mounted on surgical microscope, which enabled safe,...
BACKGROUND: Retinopathy of prematurity [ROP] continues to be a significant clinical problem in preterm infants. There is need for animal models better understand the roles hypoxia/hyperoxia pathogenesis and management ROP. OBJECTIVE
Purpose: To report the newest ophthalmic manifestations of a mother-daughter pair diagnosed with toe syndactyly, telecanthus, anogenital and renal malformations (STAR) syndrome, rare X-linked developmental disorder.Methods: The medical records were reviewed for FAM58A confirmed STAR syndrome on chromosome Xq28.Results: mother at birth had left foot anal stenosis, clitoromegaly was told 19 she hypoplastic kidney. daughter, born 38 weeks after complication oligohydramnios, more severe...
To present a series of 4 patients from the Ohio Amish or Mennonite populations with isolated ectopia lentis.
To test the efficacy of a synthetic antisense oligonucleotide inhibitor an intracellular signal transduction protein, C-raf-1 kinase, as ocular neovascularization.A 2'methoxyethyl, 2'deoxy chimeric 20-nucleotide sequence containing uniform phosphorothioate backbone was synthesized which targets 3'untranslated region porcine mRNA (ISIS 107189). Efficacy inhibition tested in vitro vascular endothelial cells and treated pigs by Northern blotting. In pig model intraocular neovascularization...
Purpose: This study aimed to develop a fully automated deep learning ciliary body segmentation and assessment approach in three-dimensional ultrasound biomicroscopy (3D-UBM) images. Methods: Each 3D-UBM eye volume was aligned the optic axis via multiplanar reformatting. Ciliary muscle processes were manually annotated, Deeplab-v3+ models with different loss functions trained segment (ciliary processes) both en face radial Results: We tested on 4320 3864 images from 12 cadaver volumes. Deep...
Purpose: To examine the waveform and clinical effects of four-muscle tenotomy reattachment procedure in fusion maldevelopment nystagmus syndrome (FMNS) to compare them those documented infantile (INS) acquired nystagmus. Methods: Both infrared reflection high-speed digital video systems were used record eye movements a patient with FMNS (before after reattachment). Data analyzed using eXpanded Nystagmus Acuity Function (NAFX) that is part OMtools software. Model simulations predictions...