A5007863784- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal Imaging and Analysis
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Sepsis Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Retinal and Optic Conditions
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Erythrocyte Function and Pathophysiology
- Atrial Fibrillation Management and Outcomes
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Sphingolipid Metabolism and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Blood properties and coagulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Artificial Intelligence in Healthcare
- Systemic Lupus Erythematosus Research
Beijing Anzhen Hospital
2020-2025
Capital Medical University
2020-2025
Capital University
2024
University of Hong Kong
2023
Beijing YouAn Hospital
2022
Neutrophil percentage-to-albumin ratio (NPAR) has been proved to be associated with clinical outcome of many diseases. This study was aimed at exploring the independent effect NPAR on all-cause mortality critically ill patients coronary artery disease (CAD).NPAR calculated as neutrophil percentage numerator divided by serum albumin concentration. Clinical endpoints were 30-day, 90-day, and 365-day mortality. Multivariable Cox proportional hazard models performed confirm association between...
Background Data on the predictive value of coronary computed tomography angiography–derived fractional flow reserve (CT‐FFR) for long‐term outcomes are limited. Methods and Results A retrospective pooled analysis individual patient data was performed. Deep‐learning‐based CT‐FFR calculated. All patients enrolled were followed‐up at least 5 years. The primary outcome major adverse cardiovascular events. secondary death or nonfatal myocardial infarction. Predictive abilities compared among 3...
Purpose: To describe the correlative relationship between fundus vascular characteristics and severity of coronary artery stenosis. Patients Methods: A total 1447 patients scheduled for hospitalization at Beijing Anzhen Hospital Union angiography to assess conditions February 2022 December were selected. Of these, 1418 cases ultimately obtained, with 29 excluded due failure complete or photography. Severity stenosis was assessed using Gensini score. Fundus images obtained via non-dilated...
Background and Aims: Low-density lipoprotein cholesterol (LDL-C) is the primary target of lipid-lowering therapy in coronary artery disease (CAD). But some patients with normal levels LDL-C still suffer from CAD progression malignant outcomes (e.g., major adverse cardiovascular events [MACEs]), mechanism unclear. The previous prospective studies demonstrated that remnant (RC) non-high-density (non-HDL-C) were capable to predict risk CAD. This study evaluated association between RC non-HDL-C...
Anion gap (AG) has been proved to be associated with prognosis of many cardiovascular diseases. This study is aimed at exploring the association AG inhospital all-cause mortality and adverse clinical outcomes in coronary care unit (CCU) patients.All data this was extracted from Medical Information Mart for Intensive Care III (MIMIC-III, version 1.4) database. All patients were divided into four groups according quartiles. Primary outcome mortality. Lowess smoothing curve drawn describe...
Computed tomography-derived fractional flow reserve (CT-derived FFR) algorithms have emerged as promising noninvasive methods for identifying hemodynamically significant coronary artery disease (CAD). However, its broad adaption is limited by the complex workflow, slow processing, and supercomputer requirement. Therefore, CT-derived FFR solutions capable of producing fast accurate results could help deliver time-sensitive rapidly potentially alter patient management. The current study aimed...
Background To determine the diagnostic performance of a novel computational fluid dynamics (CFD)-based algorithm for in situ CT-FFR patients with ischemia-induced coronary artery stenosis. Additionally, we investigated whether accuracy differs significantly across spectrum disease and analyzed influencing factors that contribute to misdiagnosis. Methods Coronary computed tomography angiography (CCTA), invasive (ICA), FFR were performed on 324 vessels from 301 six clinical medical centers....
Previous studies have demonstrated that microRNA-204 (miR-204) is involved in atherosclerosis and vascular calcification. However, the value of miR-204 as predictive biomarker for cardiovascular disease (CVD) remains unclear. We aimed to evaluate association between circulating level ten-year CVD risk based on Framingham score (FRS).In this retrospective study, we enrolled 194 consecutive patients with type 2 diabetes mellitus (T2DM) without Beijing Anzhen Hospital January 2015 September...
We investigated the association between plasma microRNA (miR)-204 and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). consecutively enrolled 179 individuals T2DM who underwent computed tomography at Anzhen Hospital from January 2015 to September 2016. The CAC score (CACS) was expressed Agatston units >10 Hounsfield were defined as CAC-positive status. Significant observed 98 (54.7%) patients. Plasma miR-204 levels (relative expression) significantly...
Objective: To explore the correlation between portal vein pressure gradient (PPG) and hepatic (HVPG) in patients with hypertension (PHT). Methods: 752 cases (PHT) who underwent transjugular intrahepatic portosystemic shunt (TIPS) met enrollment criteria January 2016 to December 2019 were analyzed for vein, inferior vena cava pressure. Paired t-test was used analysis. Pearson test estimate coefficient of determination. P<0.05 considered statistically significant. Results: Wedged (WHVP),...
Metabolic Syndrome (MS) is a rapidly growing medical problem worldwide and characterized by cluster of age-related metabolic risk factors. The presence MS increases the likelihood developing atherosclerosis significantly raises morbidity/mortality rate acute coronary syndrome (ACS) patients. Early detection crucial, biomarkers, particularly blood-based, play vital role in this process. This cross-sectional study focused on investigation certain plasma ceramides (Cer14:0, Cer16:0, Cer18:0,...
Among statin-treated patients with type 2 diabetes mellitus (T2DM), there is still a great residual cardiovascular risk. Previous studies found that the level of remnant cholesterol (RC) could predict coronary artery disease (CAD) In present study, we enrolled 4145 T2DM; 2784 (67.2%) were male and their median age was 62 years. After multivariate logistic analyses, plasma RC significantly independently associated CAD [odds ratio (OR) 13.524, 95% confidence interval (CI) = 7.058-25.912, P <...
Abstract Objective Coronary slow flow (CSF) is characterized by delayed opacification of distal epicardial coronary arteries without significant stenosis. In addition, The changes lipoprotein-associated phospholipase A2 (Lp-PLA 2 ) as a predictive factor for CSF remain controversial. study aims to investigate the association between plasma Lp-PLA and CSF. Methods this retrospective study, 170 consecutive patients who underwent angiography were enrolled in Beijing Anzhen Hospital from January...
Background: Previous studies validating fundus photographs to provide information about coronary artery disease (CAD) risk are limited. Deep learning further facilitates and enhances the use of photography.Objectives: Therefore, we aimed design prospectively validate a deep model for detecting obstructive CAD from in patients with suspected disease.Methods: We conducted multicenter study build using photographs. The algorithm was trained predict 4808 participants validation group 1385...
Abstract Previous studies validating fundus photographs to provide information about coronary artery disease (CAD) risk are limited. Deep learning further facilitates and enhances the use of photography. Therefore, we aimed design prospectively validate a deep model for detecting obstructive CADin patients with suspected disease.The algorithm was trained predict CAD using 4808 participants in validation group 1385 patientsin external test group. The performance evaluated area under receiver...
Background In patients underwent fractional flow reserve (FFR) assessment, a noteworthy proportion of adverse events occur in vessels which FFR has not been measured. However, the effect these non-target vessel-related on evaluation FFR-related benefits remains unknown. Methods and results this retrospective study, subjected to measurement were grouped as FFR-based approach non-compliance with based whether they received treatment. Using inverse probability treatment weighting (IPTW) account...
<title>Abstract</title> <bold>Background</bold>: Ceramides play a crucial role in atherosclerosis progression and have been linked to cardiovascular events. The objective of this study was investigate the association between serum ceramide levels Acute coronary syndrome, as well evaluate their potential for predicting ACS Chinese population. <bold>Methods:</bold> Data 1327 patients with suspected or known artery disease from Beijing anzhen Hospital Handan First hospital were collected....
Few studies investigated the implications of post-PCI QFR and ΔQFR (absolute increase QFR) in de novo lesions small coronary disease after drug-coated balloon (DCB). We sought to investigate prognostic patients who received DCB only. Patients were divided according optimal cutoff value ΔQFR. The primary outcome was major adverse cardiovascular events (MACE), including target vessel revascularization (TVR), cardiac death, myocardial infarction (MI). values for MACE rate 0.86 0.57,...
Abstract Background: The basic studies have demonstrated that microRNA-204 (miRNA-204) was involved in the process of atherosclerosis and vascular calcification. However, value miRNA-204 as a predictive biomarker for cardiovascular disease (CVD) is still controversial. purpose present study to evaluate association between circulating level 10-year risk score, Framingham score (FRS). Method: subjects consecutively enrolled 194 patients with type 2 diabetes mellitus without at Anzhen Hospital...
Abstract Background This article aimed to evaluate the safety and effectiveness of short-term (3–6 months) dual antiplatelet therapy (DAPT) compared long-term (12 DAPT. Methods We searched PubMed, Embase, Cochrane Library, Web Science for all randomized controlled trials which different durations DAPT after percutaneous coronary intervention within ten years before January 2021. The endpoint included major bleeding any bleeding. efficacy endpoints causes death, cardiac myocardial infarction,...