A5024018860- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Dementia and Cognitive Impairment Research
- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Neurological diseases and metabolism
- Bacterial Infections and Vaccines
- NF-κB Signaling Pathways
- Neutropenia and Cancer Infections
- Frailty in Older Adults
- Bipolar Disorder and Treatment
- Blood disorders and treatments
- Balance, Gait, and Falls Prevention
- Vector-borne infectious diseases
- Nutrition and Health in Aging
- Cerebrospinal fluid and hydrocephalus
Ospedale Antonio Cardarelli
2022-2024
Fatebenefratelli Hospital
2021
AULSS 2 Marca Trevigiana
2016-2020
National Hospital for Neurology and Neurosurgery
2020
University College London
2020
Sapienza University of Rome
2011-2018
Policlinico Umberto I
2011
We describe a case of acute relapse in woman with Multiple Sclerosis (MS) shortly after the mRNA COVID-19 vaccination. The patient received diagnosis MS November 2016 at Centre A. Cardarelli Hospital (South Italy). Since that moment, her clinical conditions and pharmacological therapies have been managed this centre where, according to national recommendations, April 2021, BNT162b2 vaccine. Almost 48 h receiving vaccine, developed paraesthesia weakness left arm limbs. neurological...
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) has emerged as an acquired immune‐mediated demyelinating disorder of the central nervous system distinct from multiple sclerosis (MS). Cognitive dysfunction and related symptoms (anxiety, depression, fatigue) their impact on quality life (QoL) have been in‐depth characterized in MS, but data adult MOGAD patients are very preliminary. Methods This study aims to characterize cognitive changes through...
To validate the adapted Italian version of Non-Motor Symptoms Scale (NMSS), a tool to assess non-motor symptoms (NMS) in Parkinson's disease (PD).A cross cultural adaptation NMSS into and psychometric analysis translated was carried out patients with PD from two university centres-affiliated hospitals. The quality data acceptability, reliability construct validity were analyzed. following standard scales also applied: Hoehn Yahr staging, Unified Disease Rating (UPDRS) part III, Montreal...
The microtubule-associated protein tau (MAPT) region has been conceptualized as a model of the interaction between genetics and functional disease outcomes in neurodegenerative disorders, such Parkinson (PD). Indeed, haplotype-specific differences expression alternative splicing MAPT transcripts affect cellular functions at different levels, increasing susceptibility to range processes. In order evaluate possible link variants, PD risk motor phenotype, we analyzed genetic architecture cohort...
Background: Frailty is a condition which characterized by reduction in the homeostatic reserves of individual and entails an increased vulnerability to stressful endogenous exogenous agents. The Index (FI), proposed Rockwood, was designed following accumulation deficits model: greater number given individual, degree frailty. Objective: aim this study verify existence associations between FI cerebral atrophy. Methods: TREDEM Register (Treviso Dementia) provided retrospective observational...
Most of the studies about conversion from Mild cognitive impairment (MCI) to dementia have focused on amnestic MCI (aMCI) which is considered a preclinical phase Alzheimer's disease. The aim present study was identify neuropsychological tools that would best predict aMCI dementia. Fifty-five subjects Treviso Dementia Registry were investigated. They underwent evaluation during their first assessment and again at follow-up. Cox proportional-hazard regression models created measure association...
Backgroundin the early stages of Multiple Sclerosis (MS), initiating high-efficacy disease-modifying therapy (HE DMTs) may represent an optimal strategy for delaying neurological damage and long-term disease progression, especially in highly active MS patients (HAMS). Natalizumab (NAT) Ocrelizumab (OCR) are recognized as HE DMTs with significant anti-inflammatory effects. This study investigates NEDA-3 achievement treatment-naïve HAMS receiving NAT or OCR over three years.Methodswe...
Background. The so-called “vaccine hesitancy” still represents a common phenomenon that undermines the effectiveness of vaccination campaigns. In 2020, Italian Medicines Agency recommended to bring forward flu campaign, whose importance was also emphasized for patients with Multiple Sclerosis (MS). We aimed assess behavior in MS prepare upcoming SARS-CoV-2 challenge. Methods. This is an observational study carried out one clinical Centre enrolled all who were eligible any vaccines by...
Nutrition plays an important role in the aging process. Adherence to Mediterranean diet (MedDiet) has been shown be associated with lower rates of diseases. Cognitive status seems strongly interrelated physical well-being, so that one influences other. Physical performance measures are not only clinical and subclinical age-related modifications, but also able predict disability, institutionalization, mortality.To evaluate prospectively associations between Mediterranean-Style Dietary Pattern...
We sought to characterize C9orf72 expansions in relation genetic ancestry and age at onset (AAO) use these measures discriminate the behavioral from language variant syndrome a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases.We evaluated frequency entire (n = 1,396; dementia [bvFTD] [n 800], primary progressive aphasia [PPA] 495], FTLD-motor neuron disease [MND] 101]). then focused on bvFTD PPA cases tested for association between expansion status, syndromes,...
We describe the case of a 61-year-old woman diagnosed with Borreliosis at age 57. Subsequently, patient developed depression, anxiety, and behavioral disturbances. A lumbar puncture excluded condition Neuroborreliosis. The diagnostic workup included: an MRI scan, 18F-FDG PET, 123I-ioflupane-SPECT, amyloid-β specific genetic analysis, neuropsychological evaluation. Based on our investigation, was probable behavioral-frontotemporal dementia (bvFTD), whereas in previous years, had been...
In the present work, we report case of a patient presenting signs Lewy body dementia (DLB) and frontotemporal (FTD) throughout different phases disease. January 2017, 79-year-old right-handed living man was admitted to our Memory Clinic for presence behavioral disturbances progressive cognitive decline. For previous six years, he monitored by other Neurological Clinics onset extrapyramidal features. Indeed, through first phase disease (2011-2014), predominantly showed: features, initial...
Epstein-Barr virus (EBV) infection increases the risk of having multiple sclerosis (MS). Data on adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are lacking.
We report the case of a woman firstly referred to our Memory Clinic at age 61, following development cognitive complaints and difficulties in sustained attention. The investigation that was performed showed: predominant executive dysfunctions neuropsychological evaluation, with mild, partial stable involvement memory domain; cortical subcortical atrophy well-preserved hippocampal structures MRI; marked fronto-temporal moderate parietal hypometabolism from 18F-FDG PET study sparing posterior...