A5063803918- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Lipid Membrane Structure and Behavior
- Cholesterol and Lipid Metabolism
- DNA Repair Mechanisms
- Cellular transport and secretion
- Nuclear Receptors and Signaling
- Cancer Genomics and Diagnostics
- Graphene and Nanomaterials Applications
- Ubiquitin and proteasome pathways
- DNA and Nucleic Acid Chemistry
- Drug Transport and Resistance Mechanisms
- Dietary Effects on Health
- Neurological Disease Mechanisms and Treatments
- Time Series Analysis and Forecasting
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Prenatal Substance Exposure Effects
- Protein Tyrosine Phosphatases
- Telomeres, Telomerase, and Senescence
- Galectins and Cancer Biology
- Neurogenesis and neuroplasticity mechanisms
Xi'an Jiaotong University
2015-2024
University of Cincinnati Medical Center
2016-2022
University of Cincinnati
2017-2018
Human CST (CTC1-STN1-TEN1) is a ssDNA-binding complex that helps resolve replication problems both at telomeres and genome-wide. resembles Replication Protein A (RPA) in the two complexes harbor comparable arrays of OB-folds have structurally similar small subunits. However, overall architecture functions RPA are distinct. Currently, mechanism underlying action diverse issues remains unclear. To clarify mechanism, we examined capacity to bind DNA structures found sites activity. We show...
Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of complementary C-strand by polymerase α is also required maintain length. Polymerase cannot perform this role without ssDNA binding complex CST (CTC1-STN1-TEN1). Here we describe roles individual subunits in telomerase regulation and G-overhang maturation human colon cancer cells. We show that CTC1-STN1 limits action overextension. CTC1-/- cells exhibit damage...
Effective urban traffic management is vital for sustainable city development, relying on intelligent systems with machine learning tasks such as flow prediction and travel time estimation. Traditional approaches usually focus static road network trajectory representation learning, overlook the dynamic nature of states trajectories, which crucial downstream tasks. To address this gap, we propose TRACK, a novel framework to bridge state data learning. TRACK leverages graph attention networks...
Effective urban traffic management is vital for sustainable city development, relying on intelligent systems with machine learning tasks such as flow prediction and travel time estimation. Traditional approaches usually focus static road network trajectory representation learning, overlook the dynamic nature of states trajectories, which crucial downstream tasks. To address this gap, we propose TRACK, a novel framework to bridge state data learning. TRACK leverages graph attention networks...
Dynamin‐related protein 1 (Drp1) is a cytosolic responsible for mitochondrial fission and essential in the initiation development of several human diseases, including cancer. However, regulation Drp1, especially its ubiquitination, remains unclear. In this study, we report that ovarian tumor‐associated protease deubiquitinase 6A (OTUD6A) deubiquitylates stabilizes thereby facilitating morphology tumorigenesis. OTUD6A upregulated patients with colorectal The depletion leads to lower Drp1...
Sleep deprivation (SD) triggers mitochondrial dysfunction and neural inflammation, leading to cognitive impairment mental issues. However, the mechanism involving inflammation still remains unclear. Here, we report that SD rats exhibited multiple behavioral disorders, brain oxidative stress, robust DNA (mtDNA) oxidation. In particular, activated microglia microglial mtDNA efflux cytosol provoked pro-inflammatory cytokines. We observed cytokines significantly reduced with suppression of With...
Alzheimer's disease (AD) is the most prevalent form of dementia in aging population; however, no effective therapy has been established. It previously demonstrated that daily intake hydroxytyrosol (HT), a polyphenol olive oil, at dietary level mildly improves cognition AD mice. In present study, HT acetate (HT-ac), which natural derivative oil exhibits better bioactivity than cognition.
The protein tyrosine phosphatase SHP2 mediates multiple signal transductions in various cellular pathways, controlled by a variety of upstream inputs. dysregulation is causative different types cancers and developmental disorders, making it promising drug target. However, how modulated its regulators remains largely unknown. Here, we use single-molecule fluorescence resonance energy transfer molecular dynamics simulations to investigate this question. We identify partially open, semiactive...
OPINION article Front. Mol. Neurosci., 21 March 2017Sec. Brain Disease Mechanisms Volume 10 - 2017 | https://doi.org/10.3389/fnmol.2017.00066
Abstract Epigenetic modifications present a great influence on tumorigenesis, and have attracted growing body of researchers’ interests. They deal with genomic information to regulate biological pathways related tumorigenesis cancer development, without changing the primary base sequence DNA. As most important epigenetic modifications, 5‐methylcytosine (5mC) 5‐hydroxmethylcytosine (5hmC) are ones widely investigated in human cancers. To expand our understanding roles 5mC 5hmC cancers,...
Alzheimer's disease (AD) patients have an increased incidence of Type 2 diabetes (T2D); however, the underlying mechanisms are not well understood. Since AD is considered a multifactorial that affects both central nerves system and periphery dysregulation hepatic lipid glucose metabolism play critical roles in T2D, we, therefore, aim to explore influence genotype on liver during progress high-fat diet (HFD)-induced T2D. Fourteen-week-old female APPSWE /PSEN1dE9 mice age-, gender-matched...
Sleep deprivation has profound influence on several aspects of health and disease. Mitochondria dysfunction been implicated to play an essential role in the neuronal cellular damage induced by sleep deprivation, but little is known about how mitochondrial ultrastructure affected under deprivation. In this report, we utilized electron cryo-tomography reconstruct three-dimensional (3-D) structure extracted morphometric parameters quantitatively characterize its reorganizations. Isolated...
Liposomes are synthetic phospholipid vesicles containing an aqueous lumen confined by a lipid bilayer. These have been used as nanoreactors because they offer environments that can result in significant changes to chemistry. However, major limitation of using liposomes nanocontainers is the impermeability their membranes. To overcome this, scientists tested use porous generated membrane phase or pore formation proteins. In this study, selective permeability molecules smaller than threshold...
Abstract Nanoparticles have received significant research interest for potential biomedical applications. Before nanomaterials are administered to patients, their biocompatibility should be thoroughly evaluated through in vitro experiments and other preclinical procedures. Many studies sought assess the toxicity of on synaptic transmission neuroscience However, it may hard perform such because difficulty associated with delivering synthesized across cell membranes. Here, an method is...
In addition to beta-amyloid (Aβ) plaques and neurofibrillary tangles, Alzheimer's disease (AD) is typically triggered or accompanied by abnormal inflammation, oxidative stress astrocyte activation. Safflower (Carthamus tinctorius L.) leaf, featuring functional ingredients, a commonly consumed leafy vegetable. Whether how dietary safflower leaf powder (SLP) ameliorates cognitive function in an AD mouse model has remained minimally explored. Therefore, we orally administered SLP APP/PS1...
An in vitro vesicle system that mimics neuronal exocytosis is employed for nanotoxicity testing by Jiajie Diao and co-workers article number 1700207. The experimental scheme consists of leakage content-mixing experiments to test the effects nanomaterials on membrane integrity synaptic fusion, respectively. results demonstrate potential this as a novel platform assessing biocompatibility nanomaterials, drug molecules, other substances. These may offer faster easier approach measuring nanotoxicity.