A5101828611- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Advanced Fluorescence Microscopy Techniques
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Transcranial Magnetic Stimulation Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Aquaculture disease management and microbiota
- Optical Coherence Tomography Applications
- Neuroscience and Neural Engineering
- Phytochemistry and Biological Activities
- Biosensors and Analytical Detection
- Dermatology and Skin Diseases
- Spinal Fractures and Fixation Techniques
- Photoacoustic and Ultrasonic Imaging
- Cerebrovascular and Carotid Artery Diseases
- Digital Holography and Microscopy
- Psoriasis: Treatment and Pathogenesis
- Memory and Neural Mechanisms
- Nanocomposite Films for Food Packaging
- Epilepsy research and treatment
- Spinal Cord Injury Research
- Whipple's Disease and Interleukins
- Invertebrate Immune Response Mechanisms
Tianjin Medical University
2016-2025
Shandong University of Traditional Chinese Medicine
2023-2025
Jiangnan University
2024
Shanxi Medical University
2024
Tianjin Medical University General Hospital
2021
Yale University
2013
Fudan University
2011
Astrocytes are the primary cell type in central nervous system, responsible for maintaining stability of brain’s internal environment and supporting neuronal functions. Researches have demonstrated close relationship between astrocytes pathophysiology etiology major depressive disorder. However, regulatory mechanisms during depression remain unclear. The aim this study is to examine alterations calcium signaling dorsal raphe nucleus (DRN), neurons both DRN medial prefrontal cortex (mPFC),...
Abstract A low‐cost, high‐precision, and secure real‐time system for monitoring food freshness can significantly improve spoilage issues, yet traditional colorimetric sensor arrays often suffer from chemical dyes’ high toxicity limited color changes. Here, a metal‐polyphenol network array (MPN‐CSA) is built detecting total volatile base nitrogen (TVB‐N) markers of meat freshness. The multi‐level competitive coordination process between the amine substances endows with changes far beyond...
Sleep deprivation (SD) triggers mitochondrial dysfunction and neural inflammation, leading to cognitive impairment mental issues. However, the mechanism involving inflammation still remains unclear. Here, we report that SD rats exhibited multiple behavioral disorders, brain oxidative stress, robust DNA (mtDNA) oxidation. In particular, activated microglia microglial mtDNA efflux cytosol provoked pro-inflammatory cytokines. We observed cytokines significantly reduced with suppression of With...
Sleep deprivation (SD) has a profound impact on the central nervous system, resulting in an array of mood disorders, including depression and anxiety. Despite this, dynamic alterations neuronal activity during sleep have not been extensively investigated. While some researchers propose that diminishes activity, thereby leading to depression. Others argue short-term enhances dendritic spine density, potentially yielding antidepressant effects. In this study, two-photon microscope was utilized...
Anodal-transcranial pulsed current stimulation (a-tPCS) has been used in human studies to modulate cortical excitability or improve behavioral performance recent years. Multiple show crucial roles of astrocytes plasticity. The calcium activity could regulate synaptic transmission and Whether the astrocytic is involved a-tPCS-induced plasticity presently unknown. purpose this study investigate responses neurons evoked by a-tPCS with different intensities, thereby provides some indication...
In recent years, several pathogens have emerged and caused heavy mortality in Asia. this study, we investigated the prevalence of specimens whiteleg shrimp (Penaeus vannamei) collected from greenhouse ponds. total, six were tested these shrimp, three which, including Enterocytozoon hepatopenaei (EHP), acute hepatopancreatic necrosis disease (AHPND)-causing Vibrio parahaemolyticus infectious hypodermal haematopoietic virus (IHHNV), detected aquaculture, with EHP being most prevalent; Taura...
The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability IL-23-induced signal transduction circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible differences IL-23 responsiveness (measured by STAT3 phosphorylation) peripheral blood CD8+CD45RO+ memory T and CD3+CD56+ NKT cells. Age, but gender, was significant (Pearson's correlation...
Objective. Electrical brain stimulation has been used to ameliorate symptoms associated with neurologic and psychiatric disorders. The astrocytic activation its interaction neurons may contribute the therapeutic effects of electrical stimulation. However, how activity is affected by calcium signaling mechanisms remain largely unknown. This study explore influence stimulus parameters on cellular responses corresponding mechanisms, a focus heretofore overlooked astrocytes.Approach. Usingin...
Multiple sclerosis (MS) is a chronic disease in the central nervous system (CNS), characterized by inflammatory cells that invade into brain and spinal cord. Among bulk of different MS models, most widely used best understood rodent model experimental autoimmune encephalomyelitis (EAE). Arctigenin, botanical extract from Arctium lappa, reported to exhibit pharmacological properties, including anti-inflammation neuroprotection. However, effects arctigenin on neural activity attacked...
Abstract Aims Neuropathic pain after spinal cord injury (SCI) remains a common and thorny problem, influencing the life quality severely. This study aimed to elucidate reorganization of primary sensory cortex (S1) regulatory mechanism lateral parabrachial nucleus (lPBN) in presence allodynia or hyperalgesia left hemisection (LHS). Methods Through behavioral tests, we first identified mechanical thermal following LHS. We then applied two‐photon microscopy observe calcium activity S1 during...
Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that refractory, resistant to antiepileptic drugs, and has high recurrence rate. The pathogenesis of temporal complex not fully understood. Intracellular calcium dynamics have been implicated in epilepsy. However, the effect fluctuating activity CA1 pyramidal neurons on unknown, no longitudinal studies investigated hippocampal primary motor cortex M1 freely moving mice. In this study, we used multi-channel fiber...
The aim of this study was to compare the clinical value vertebral artery ultrasound (VAU), Magnetic Resonance Angiography (MRA) and Digital Subtraction (DSA) on stenosis in patients with posterior circulation ischemia. Seventy-three ischemia underwent magnetic resonance angiography as well digital subtraction angiography, diagnosis (VAS) degree (normal, mild stenosis, moderate severe occlusion) were recorded compared between angiogram angiography. rates 87.30 % (55/63) 49.20 (31/63),...
PDF HTML阅读 XML下载 导出引用 引用提醒 南美白对虾肝肠胞虫的分离及形态学观察 DOI: 作者: 作者单位: 江苏省海洋水产研究所, 江苏 南通 226007 作者简介: 乔毅(1987-),男,助理工程师,主要从事水生动物病害学研究.E-mail:qiaoyishou@yeah.net 通讯作者: 中图分类号: S945 基金项目: 江苏省重点研发计划(现代农业)项目(BE2017384);江苏省海洋水产研究所青年科学基金项目(SQ201705);江苏省渔业科技项目(Y2017-020);2018年农业生态环境保护项目(171821104022292002);江苏省中央引导地方科技发展专项资金项目(YDZX20173200001267). Preliminary isolation and morphological observation of Enterocytozoon hepatopenaei infecting the shrimp Penaeus vannamei Author: Affiliation: Jiangsu Institute...
In this paper, we present a fluorescence collection enhancement method for multiphoton microscopy by quarter ellipsoidal reflector (QER). It is proven to be compatible with commercially available two-photon microscopes without significant customization. The structure and working principle of the QER demonstrated. A was fabricated collect most backscattered photons not collected an objective lens epifluorescence microscope then reflected into external detector. Fluorescence efficiency...
Abstract Background Multiple sclerosis (MS) is a chronic disease in the central nervous system (CNS), characterized by inflammatory cells invade into brain and spinal cord. Among bulk of different MS models, rodent model experimental autoimmune encephalomyelitis (EAE) most widely used best understood. Arctigenin, botanical extract from Arctium lappa, reported to exhibit pharmacological properties including anti-inflammation neuroprotection. However, effects Arctigenin on neural activity...
Abstract 4Pi stimulated emission depletion (STED) microscopy shows outstanding three-dimensional (3D) isotropic super-resolution imaging performance. However, this technology is still difficult for achieving long-term studying of the synapses that are deeply embedded inside brain tissue. Metalens, which can realize arbitrary nanoscale amplitude, phase, and polarization modulations, a very useful tool to solve limitation. In paper, an ultracompact two-photon STED involved two multifunctional...
Acute hepatopancreatic necrosis disease (AHPND) is an important bacterial occurring early after stocking shrimp fry in ponds with the mortalities of 100 %. AHPND leads to significantly drop production and brings out huge economic losses worldwide. Thus, rapid, accurate, convenient on-site detection method urgent need monitor outbreak spreading especially for equipment-poor areas. Application traditional PCR-based methods restricted due dependence on laboratory equipment technicians. In this...