A5023904644- Streptococcal Infections and Treatments
- Listeria monocytogenes in Food Safety
- Microbial Inactivation Methods
- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Microbial infections and disease research
- Salmonella and Campylobacter epidemiology
- Aquaculture disease management and microbiota
- Plant Pathogenic Bacteria Studies
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Infections and bacterial resistance
- Bacterial Identification and Susceptibility Testing
- Cancer Treatment and Pharmacology
- Flavonoids in Medical Research
- Neonatal and Maternal Infections
- Synthetic Organic Chemistry Methods
- Coastal wetland ecosystem dynamics
- Environmental Quality and Pollution
- Toxoplasma gondii Research Studies
- Reproductive biology and impacts on aquatic species
- Soil Carbon and Nitrogen Dynamics
- Biosensors and Analytical Detection
- GABA and Rice Research
- Invertebrate Immune Response Mechanisms
Jiangsu Academy of Agricultural Sciences
2012-2024
Shanxi Zhendong Pharmaceutical (China)
2016-2022
China Animal Health and Epidemiology Center
2016-2021
Sun Yat-sen University
2021
Zhejiang University
2021
Huazhong Agricultural University
2020-2021
Xinjiang Medical University
2021
Northwest A&F University
2021
Chinese Center For Disease Control and Prevention
2021
South China Agricultural University
2021
Increased soil salinity significantly inhibits crop production worldwide, and biochar may alleviate salt stress. In the present study, application of increased biomass rice under stress treatment. The analysis properties demonstrated that decreased electrical conductivity soluble Na+ Cl− contents in addition, cation exchange capacity, organic matter, humic acid, total nitrogen, phosphorus soil, suggesting improved nutrient conditions. further abundance bacteria changed bacterial community...
Streptococcus suis (S. suis), more specifically serotype 2, is a bacterial pathogen that threatens the lives of pigs and humans. Like many other pathogens, S. exhibits quorum sensing (QS) system-controlled virulence factors, such as biofilm formation complicates treatment. Therefore, impairing QS involving LuxS/AI-2 cycle in suis, may be promising alternative strategy for overcoming infections. In this study, we investigated paeoniflorin (PF), monoterpenoid glycoside compound extracted from...
Streptococcus equi subsp. zooepidemicus is an opportunistic pathogen. It has caused a very large economic loss in the swine industry of China and become threat to human health. We announce complete genome sequence S. strain ATCC 35246, which provides opportunities understand its pathogenesis mechanism genetic basis.
Clostridium perfringens is an important pathogen for both humans and animals, causing human foodborne disease necrotic enteritis in poultry. In the present study, a C. perfringens-specific phage, vB_CpeS_BG3P (designated as BG3P hereafter), was isolated from chicken farm sewage. Both electron microscopy phylogenetic analysis suggested that phage novel belonging to Siphoviridae family. Phage exhibited broad host range against different isolates (90.63% of strains were infected). Sequencing...
Molecules contributing to microbial cytoadhesion are important virulence factors. In Mycoplasma bovis, a minimal bacterium but an cattle pathogen, binding host cells is emerging as complex process involving broad range of surface-exposed structures. Here, new cytoadhesin M. bovis was identified by producing collection individual knock-out mutants and evaluating their embryonic bovine lung cells. The cytoadhesive-properties this protein, which encoded Mbov_0503 in strain HB0801, were...
Autoimmune diseases, induced by dysfunction of the adaptive immune system, are common disease categories worldwide. Recently, regulatory T cells (Tregs) enhancing therapies have been demonstrated to treat autoimmune which could induce tolerance protect and tissues from self-attacking system. However, their widespread application is limited complex manufacturing process, long production period high cost. Herein, we give a perspective immune-homeostatic particles as regulators antigen-specific...
Mycoplasmas are host-restricted prokaryotes with a nearly minimal genome. To overcome their metabolic limitations, these wall-less bacteria establish intimate interactions epithelial cells at mucosal surfaces. The alarming rate of antimicrobial resistance among pathogenic species is particular concern in the medical and veterinary fields. Taking advantage reduced mycoplasma genome, random transposon mutagenesis was combined high-throughput screening order to identify key determinants...
Streptococcus equi ssp. zooepidemicus (S. zooepidemicus, S.z) is one of the common pathogens that can cause septicemia, meningitis, and mammitis in domesticated species. M-like protein (SzP) an important virulence factor S. contributes to bacterial infection antiphagocytosis. The interaction between SzP porcine thioredoxin (TRX) was identified by yeast two-hybrid further confirmed co-immunoprecipitation. interacted with both reduced oxidized forms TRX without inhibiting activity. Membrane...
Streptococcus equi ssp. zooepidemicus (S. zooepidemicus) is responsible for a wide variety of infections in many species. Fibronectin-binding protein bacterial cell surface protein, which specifically binds fibronectin (FN). Considering the specific role FN-binding host-pathogen interactions, we investigated function novel domain (FNZ) S. zooepidemicus. Five recombinant FNZ gene fragments [N1 (amino acids, 38-197), N2 38-603), N3 41-315), N4 192-370), and N5 38-225)] were expressed...
The mariner-based Himar1 system has been utilized for creating mutant libraries of many Gram-positive bacteria. Streptococcus suis serotype 2 (SS2) and equi ssp. zooepidemicus (SEZ) are primary pathogens swine that threaten the industry in China. To provide a forward-genetics technology finding virulent phenotype-related genes these two pathogens, we constructed novel temperature-sensitive suicide shuttle plasmid, pMar4s, which contains transposon, TnYLB-1, C9 transposase from pMarA repTAs...
Non-coding RNAs (ncRNAs) have gained increasing attention as their diverse roles in virulence and environmental stress Listeria monocytogenes become clearer. The ncRNA rliB is an atypical member of the CRISPR family, conserved at same genomic locus all analyzed L . genomes also other species. In this study, defective mutants (Lm3-22-Δ ) were constructed by homologous recombination. growth cycle Lm3-22-Δ was slower than that wild-type Lm3-22. sensitivity to phage vB-LmoM-SH3-3 significantly...
Swine streptococcosis is a significant threat to the Chinese pig industry, and Streptococcus equi ssp. zooepidemicus (SEZ) one of major pathogens. SEZ ATCC35246 classical virulent strain, while ST171 attenuated vaccine strain. In this study, we employed stable isotope labeling by amino acids in cell culture liquid chromatography–mass spectrometry (LC–MS) determine differential response macrophages infection these two strains. Eighty-seven upregulated proteins 135 downregulated were...
Streptococcus suis type 2 (SS2) is an important zoonotic pathogen. We have previously reported the structure of LuxS protein and found that luxS gene closely related to biofilm, virulence expression drug resistance SS2. However, mechanism mediated SS2 stress response unclear. Therefore, this experiment performed mutant (ΔluxS) complement strain (CΔluxS), overexpression (luxS+) wild-type HA9801, analyzed differential phenotypes in combination with transcriptome data.The results indicate...
Abstract Telocytes ( TC s) and their telopodes (Tps) have been found in various organs of many mammals, including lower animals. However, knowledge s animals is still very limited. This study identified Tps the ileum Chinese giant salamander, Andrias davidianus (Amphibia: Caudata), by transmission electron microscopy. The s/Tps were near epithelial cells, glandular cells unmyelinated nerve fibres. Moreover, exosomes also to be present between these cells.
Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures characterized using NMR MS spectral data. The cytotoxicity two was performed on breast cancer cell lines MCF-7, MX-1 MDA-MB-231. It is remarkable that both these desired taxanes showed great potent cytotoxic effect. Keywords: Larotaxel, taxanes, synthesis, cytotoxicity, cancer.
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