A5043882385- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Inflammasome and immune disorders
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glutathione Transferases and Polymorphisms
- Advanced Glycation End Products research
- Bone Metabolism and Diseases
- Natural Antidiabetic Agents Studies
- Ginseng Biological Effects and Applications
- Sphingolipid Metabolism and Signaling
- Cancer Treatment and Pharmacology
- Phytochemistry and Biological Activities
- Inflammatory mediators and NSAID effects
- Plant Toxicity and Pharmacological Properties
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Psidium guajava Extracts and Applications
- Herbal Medicine Research Studies
- Hops Chemistry and Applications
- Ion Channels and Receptors
- Natural Compound Pharmacology Studies
Pusan National University
2013-2023
Dunsan Korean Medicine Hospital
2021
National Clinical Research
2020-2021
Korean National Police University
2017
Ginseng regulates gastrointestinal (GI) motor activity but the underlying components and molecular mechanisms are unknown. We investigated effect of gintonin, a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand, on pacemaker interstitial cells Cajal (ICC) in murine small intestine GI motility.Enzymatic digestion was used to dissociate ICC from mouse intestines. The whole-cell patch-clamp configuration record potentials currents cultured absence or presence...
The fruit hull of Gleditsia sinensis (FGS) has been prescribed as a traditional eastern Asian medicinal remedy for the treatment various respiratory diseases, but efficacy and underlying mechanisms remain poorly characterized. Here, we explored potential usage FGS acute lung injury (ALI), highly fatal inflammatory disease that urgently needs effective therapeutics, investigated mechanism anti-inflammatory activity FGS. Pretreatment C57BL/6 mice with significantly attenuated LPS-induced...
Abstract Background The fruit hull of Gleditsia sinensis (FGS) used in traditional Asian medicine was reported to have a preventive effect on lung inflammation an acute injury (ALI) mouse model. Here, we explored FGS as possible therapeutics against inflammatory diseases including ALI, and examined underlying mechanism for the FGS. Methods decoction water prepared fingerprinted. Mice received intra-tracheal (i.t.) 2 h after intra-peritoneal (i.p.) injection lipopolysaccharide (LPS)....
Geranium thunbergii Sieb. et Zucc. (GT; which belongs to the Geraniaceae family) has been used as a traditional medicine in East Asia for treatment of inflammatory diseases, including arthritis and diarrhea. However, underlying mechanisms anti-inflammatory effects GT remain poorly understood. In present study, we examined responsible activity macrophages. The results revealed that significantly inhibited lipopolysaccharide (LPS)- interferon-γ (IFN-γ)-induced expression pro-inflammatory...
Although Alisma orientale , an ethnic herb, has been prescribed for treating various diseases in Asian traditional medicine, experimental evidence to support its therapeutic effects is lacking. Here, we sought determine whether A. a effect on acute lung injury (ALI). Ethanol extract of the tuber (EEAO) was prepared and fingerprinted by HPLC constituents. Mice received intraperitoneal (i.p.) injection lipopolysaccharide (LPS) induction ALI. At 2 h after LPS treatment, mice intratracheal...
Lung cancer has substantial mortality worldwide, and chemotherapy is a routine regimen for the treatment of patients with lung cancer, despite undesirable effects such as drug resistance chemotoxicity. Here, given possible antitumor effect fruit hull Gleditsia sinensis (FGS), we tested whether FGS enhances effectiveness cis ‐diammine dichloridoplatinum (II) (CDDP), chemotherapeutic drug. We found that CDDP, when administered FGS, significantly decreased viability increased apoptosis cell...
Abstract Since aesculin, 6,7-dihydroxycoumarin-6- O -β-glucopyranoside, suppresses inflammation, we asked whether its anti-inflammatory activity is associated with the activation of nuclear factor-E2-related factor 2 (Nrf2), a key factor. Our results, however, show that aesculin marginally activated Nrf2. glycosylation can enhance function compound, then adding glucose makes activate results glycosylated 3- -β- d -glycosyl robustly Nrf2, inducing expression Nrf2-dependent genes, such as heme...
Acute lung injury (ALI) is an inflammatory disease with high mortality, but therapeutics against it unavailable. Recently, we elaborated a formula, named Chung-pae (CP), that comprises four ethnic herbs commonly prescribed various respiratory diseases in Asian traditional medicine. CP being administered aerosol to relieve symptoms of patients our clinic. Here, sought examine whether has therapeutic effect on ALI and uncover the mechanism behind it. Reporter assays show suppressed...
Although acute lung injury (ALI) is a leading cause of death in intensive care unit, effective pharmacologic means to treat ALI patients are lacking. The rhizome Picrorhiza scrophulariiflora used traditional herbal medicine Asian countries has been shown have anti-inflammatory function, and picroside II (PIC II) known as major constituent the plant. Here, we examined whether PIC an activity, which applicable for treating ALI. We found that although it not significantly suppressing...
Bojungikki‐tang (BT), an Asian herbal remedy, has been prescribed to increase the vitality of debilitated patients. Since a compromised, weakened often leads illness, BT widely used treat various diseases. However, little is known about mechanism by which exerts its effect. Given that ameliorates inflammatory pulmonary diseases including acute lung injury (ALI), we investigated whether regulates function key factors such as NF‐ κ B and Nrf2, contributing suppressing inflammation. Results...