A5075682945- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Antibiotic Resistance in Bacteria
- Virology and Viral Diseases
- Bacterial biofilms and quorum sensing
- Autism Spectrum Disorder Research
- Epigenetics and DNA Methylation
- Escherichia coli research studies
- Syphilis Diagnosis and Treatment
- Animal Disease Management and Epidemiology
- Autophagy in Disease and Therapy
- Viral Infections and Immunology Research
- Genetic and Kidney Cyst Diseases
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Vector-borne infectious diseases
- Wnt/β-catenin signaling in development and cancer
- Physiological and biochemical adaptations
- Food Supply Chain Traceability
- Advanced Neuroimaging Techniques and Applications
- Calcium signaling and nucleotide metabolism
- Parvovirus B19 Infection Studies
Fujian Academy of Agricultural Sciences
2019-2024
Animal Science Research Institute
2019-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Peking Union Medical College Hospital
2023
China Animal Disease Control Center
2017-2022
Central Hospital of Zibo
2022
Fudan University
2020
Animal Husbandry & Veterinary
2019
Huazhong Agricultural University
2012-2018
Guangxi Medical University
2011-2013
Abstract Despite vaccine use, novel strains and variants of infectious bronchitis virus (IBV) have emerged continuously, leading to economic losses the poultry industry worldwide. This study aimed characterize IBV isolate CK/CH/GX/202109 from three yellow broilers in Guangxi, China. Recombination was shown occurred regions 1ab gene. Compared whole genome ck/CH/LGX/130530, which is genotypically related tl/CH/LDT3-03, 202109 strain had 21 mutations. The pathological assessment showed that...
Since 2018, atrophy of the bursa has been found among vaccinated chickens with high antibody titres against infectious bursal disease virus (IBDV) in Fujian, China, suggesting poor vaccine efficacy circulating IBDV strains.Novel strains were isolated, and vp2 vp1 genes sequenced used to carry out phylogenetic analysis. Pathogenicity was investigated using 21-day-old specific pathogen-free (SPF) chickens. In addition, effectiveness current commercial vaccines China evaluated isolated novel...
The novel variant IBDV (nVarIBDV, genotype A2dB1), characterized by bursal atrophy of fabricius and decreased lymphocytes, has been emerging on a large scale in Asia (including China) since late 2018. nVarIBDV is new threat to the poultry industry, yet currently licensed commercial vaccines, including live viral vector vaccine, immune complex vaccine or VP2 subunit are ineffective against infection. In this study, specific-pathogen-free (SPF) chickens broilers divided into three groups were...
Cytochrome b5 reductase 2 (CYB5R2), a member of the flavoprotein pyridine nucleotide cytochrome family, is associated with number physiological reactions. However, its role in cancer, especially nasopharyngeal carcinoma (NPC), has not been addressed. Here, we investigate transcript levels and promoter methylation status CYB5R2 NPC derived cell lines tumor biopsies experimentally address as suppressor gene. We find that are decreased biopsies. Promoter hypermethylation was detected all six...
While a high osmolarity medium activates Cpx signaling and causes CpxR to repress csgD expression, efflux protein TolC plays an important role in biofilm formation Escherichia coli, whether also responds change regulate extraintestinal pathogenic E. coli (ExPEC) remains unknown. In this study, we constructed ΔtolC mutant complement ExPEC strains investigate the of retention curli production capability under different osmotic conditions. The showed significantly decreased lost ability produce...
Our previous study showed that the inactivation of efflux pump TolC could abolish biofilm formation and curli production extraintestinal pathogenic Escherichia coli (ExPEC) strain PPECC42 under hyper-osmotic conditions. In this we investigated role OmpX in ExPEC PPECC42. data disruption or overexpression didn't significantly affect wild-type strain. However, tolC-deleted mutant, overexpressing suppressed effect on growth Real-time qRT-PCR confirmed affected by regulating transcription...
Outer membrane protein X (OmpX) and its homologues have been proposed to contribute the virulence in various bacterial species. But, their role of extraintestinal pathogenic Escherichia coli (ExPEC) is yet be determined. This study evaluates OmpX ExPEC vitro vivo using a clinical strain PPECC42 porcine origin. The ompX deletion mutant exhibited increased swimming motility decreased adhesion to, invasion pulmonary epithelial A549 cell, compared wild-type strain. A mild increase LD50 distinct...
The novel variant IBDV (nVarIBDV, especially genotype A2dB1) mainly affects broilers in China. It causes an infection characterized by the atrophy of bursa, a decrease level lymphocytes, proliferation fibrous tissue around follicle, and severe follicle bursa. Poultry vaccinated with live vaccines do not have challenge present bursa atrophy, which is misdiagnosed for nVarIBDV because lack other gross clinical symptoms. study sought to explore potential reliability real-time TaqMan analysis...
Duck plague (DP) is a highly contagious viral disease in ducks caused by the duck virus (DPV). The DPV, member of Herpesviridae, poses severe threat to waterfowl farming industry worldwide. In this study, we reported recent outbreak DPV domestic laying at 310 days age from southern China December 2021. gross lesion, histopathologic examination, molecular detection, and genetic characterization studies are described here. As result, lesions such as an enlarged congestive spleen liver were...
The emerging porcine circovirus type 3 (PCV3) has been reported in Chinese swine herds since 2017. We performed a nationwide investigation on the prevalence of PCV3 pig breeding farms and slaughterhouses China. A total 4,040 tonsil samples were collected from 89 25 provinces, 1,419 lymph node 50 27 provinces. PCR results showed that farms, positive rate was 41.6% (37/89) at farm level 5.0% (201/4040) individual level. In slaughterhouses, 62.0% (31/50) 8.0% (114/1419) PCR-positive further...
An emerging pseudorabies virus (PRV) variant has been reported on Bartha-K61-vaccinated farms since 2011, causing great economic losses to China's swine-feeding industry. In this study, two vaccines, FJ-2012ΔgE/gI-GEL02 and FJ-2012ΔgE/gI-206VG, were administered piglets for immune efficacy investigation. Humoral immunity response, clinical signs, survival rate, tissue viral load, pathology assessed in piglets. The results showed that both vaccines effective against the PRV FJ-2012 challenge,...
To investigate the influence of exposure to high-altitude (HA) hypoxia on expressions endothelin-1 (ET-1), endothelin type A (ETA) and B (ETB) receptors in broiler chickens, immunohistochemistry studies were performed lungs. Six hundred 1-day-old male chickens randomly divided into two groups: group A, birds maintained under rich oxygen conditions (oxygen content 21%); B, exposed HA 13%). Our data showed that altitude elevated ET-1 ETA gene at 21 28 days age when compared with group....
ObjectiveTo investigate the correlation between parameters of PET/MR and expression level epidermal growth factor receptor (EGFR) in head neck squamous cell carcinoma (HNSCC) to evaluate diagnostic efficacy independent combined for EGFR.Materials methods21 patients who had undergone been proven HNSCC pathologically were included this retrospective study. The sequences 18-flurodeoxyglucose (18F-FDG) PET, T1, T2-weighted imaging, DWI, ADC DCE. Parameters including ADCmean from Ktrans, Ve, Kep...
NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds 2012.To explore the possible genetic diversity these strains, we sequenced analyzed complete genomes two strains. These isolates shared 95.4% homology with NADC30.The displayed a discontinuous deletion 131 amino acids NSP2, mutations GP3 GP5, 3-nucleotide 3' untranslated region. Phylogenetic analysis showed that formed new branch clustered subgroup NADC30 from North America.We...
Atherosclerosis (AS) is a chronic inflammatory disease with high morbidity and mortality worldwide the pathologic basis of cerebral-cardiovascular disease. Cerebral infarction caused by cerebral ischemia in deep brain stem or hemisphere, small vessel atherosclerosis pathophysiological lacunar infarction. In this study, we found that inhibition PARP1 neuronal cells increased proliferation rate cells, reduced concentration cholesterol inhibited expression secretion proinflammatory factors...
Objective To investigate the key points for management of subclinical and agonal types penetrating cardiac trauma (PCT).Methods A retrospective analysis was conducted on clinical data 135 PCT cases treated from January 2005 to March 2012.The were divided into type,clinical type (cardiac tamponade or hemorrhagic shock types) type.Managements two extreme including studied in groups.Results (1) Thirty failed have timely diagnosis treatment due withdrawal inhospital observation,which resulted 22...