In addition to colorectal cancer and metabolic syndrome, regular yogurt consumption has shown promise in improving skin inflammation. this study, we investigated the effects possible mechanisms of on imiquimod-induced psoriasis-like inflammation mice. After oral administration with (18 or 36 g/kg) and/or its main metabolite lactate (250 500 mg/kg) for 3 days, mice were treated a topical dose 62.5 mg imiquimod (IMQ) cream seven consecutive days. Data showed that treatment significantly...

Introduction The impact of the hypermucoviscosity (HMV) phenotype in ST11-KL47 carbapenem-resistant Klebsiella pneumoniae (CRKp) pathogenicity warrants investigation for public health risk assessment. Methods We analyzed 230 clinical CRKp to identify key factor mucoviscosity acquisition via comparative genomic analysis. Sedimentation value served as objective index quantify HMV. virulence vivo was assessed using Galleria mellonella and mouse infection models. employed genome engineering,...

Abstract Background Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity disorders humans remains largely unknown. We aimed to address this gap by determining IL-33 serum downstream type 2 inflammatory cytokines interleukin-5 (IL-5) interleukin-13 (IL-13) overweight/obese population, analyzing the specific associations between phenotypes. Methods 217 subjects were enrolled...

Perinatal exposure to polybrominated diphenyl ethers (PBDEs) may be a potential risk factor for autism spectrum disorders (ASD). BDE-47 is one of the most common PBDEs and poses serious health hazards on central nervous system (CNS). However, effects perinatal social behaviors mechanisms are largely unexplored. Thus, we aimed investigate whether during gestation lactation led autistic-like in offspring rats present study. Valproic acid (VPA), which widely used establish animal model ASD, was...

Purpose Serum uric acid (UA) not only affects the development of obesity but also alters metabolic status in obese subjects; thus we investigated relationship between serum UA and overweight/obese phenotypes. Methods The demographic, biochemical, hematological data were collected for 12,876 patients undergoing routine physical examination, 6,912 participants enrolled our study. Participants classified into four phenotypes according to their BMI presence syndrome: metabolically healthy...

Excessive hepatic glucose production (HGP) is a major cause of fasting hyperglycemia in diabetes, and antihyperglycemic therapy takes center stage. Nonsteroidal anti-inflammatory drugs, such as acetylsalicylic acid (aspirin), reduce caused by unrestrained gluconeogenesis but its mechanism incompletely understood. Here, we reported that aspirin lowers blood gluconeogenesis, corresponds with lower thromboxane A2 (TXA2) levels, the hypoglycemic effect could be rescued TP agonist treatment. On...

Exercise exerts many beneficial effects on obesity, but the mechanism remains elusive. Here, we report a previously unidentified role of lactate receptor GPR81 in exercise. We observed that was significantly up-regulated white adipose tissues (WAT) upon exercise training both lean and obese mice. could induce thermogenesis beige adipocyte development, whereas such an effect markedly impaired by deficiency GPR81. Furthermore, activation supplementation (250 or 500 mg/kg) yielded synergistic...

Background and Purpose Defective insulin signalling dysfunction of the endoplasmic reticulum (ER), driven by excessive lipid accumulation in liver, is a characteristic feature pathogenesis non‐alcoholic fatty liver disease (NAFLD). Thromboxane A 2 (TXA ), an arachidonic acid metabolite, significantly elevated obesity plays crucial role hepatic gluconeogenesis adipose tissue macrophage polarization. However, TXA /TP receptors resistance metabolism largely unknown. Experimental Approach TP...

Osteoarthritis (OA) is a prevalent debilitating disease which predominantly characterized by cartilage degeneration. In the current study, destabilization of medial meniscus (DMM) mouse model was used to investigate effects Antarctic krill peptides (AKP) on protection. As observed, AKP clearly ameliorate degeneration as evidenced increased thickness and area decreased histological Research Society International (OARSI) scores. Toluidine blue staining showed that AKO remarkably inhibited loss...

Osteoarthritis (OA), a common chronic disease, is characterized by articular cartilage degeneration and inflammation. Recent studies report that n-3 polyunsaturated fatty acids (PUFAs) exhibit protective effects against OA, while n-6 PUFAs are more likely to damage cartilage. However, the of edible oils with different n-6/n-3 PUFA ratios on OA rarely reported. This study investigates effect linseed oil (LO), soybean (SO), peanut (PO) changes in mice joints following destabilization medial...

COVID-19 caused by SARS-CoV-2 is sweeping the world and posing serious health problems. Rapid accurate detection along with timely isolation key to control epidemic. Nucleic acid test antibody-detection have been applied in diagnosis of COVID-19, while both their limitations. Comparatively, direct viral antigens clinical specimens highly valuable for early SARS-CoV-2. The nucleocapsid (N) protein one predominantly expressed proteins high immunogenicity during stages infection. Here, we...

Osteoarthritis (OA), the most common form of arthritis, is characterized by cartilage destruction, and its incidence much higher in osteoporotic population. There increasing evidence that occurrence development OA are modulated dietary intake polyunsaturated fatty acids (PUFA). This study investigated effects PUFA, including n-3/n-6 PUFA proportion molecular n-3 on using osteoarthritis dual model mice, where phospholipid type were specifically examined. The results revealed a low n-6/n-3...

Background: With the improvements in living standards, height is getting more attention. Malnutrition one of main causes children's short stature; therefore, nutritional intervention adolescence key to prevent stature. The peptides from Antarctic Krill (AKPs), ideal protein model, act bone formation and anti-osteoporosis. However, studies on promoting longitudinal growth by AKPs have not been reported. Methods: Three-week-old male ICR mice, construct adolescent mice randomly divided into...

To contain the pandemics caused by SARS-CoV-2, early detection approaches with high accuracy and accessibility are critical. Generating an antigen-capture based system would be ideal strategy complementing current methods on nucleic acids antibody detection. The spike protein is found outside of virus particles appropriate for antigen detection.In this study, we utilized bioinformatics to explore immunodominant fragments SARS-CoV-2.The S1 subunit was identified higher sequence specificity....

Numerous studies have investigated the immunomodulatory effects of yogurt, but underlying mechanism remained elusive. This study aimed to elucidate alleviating properties yogurt on immunosuppression and proposed was related metabolite D-lactate. In healthy mice, we validated safety daily consumption (600 μL) or D-lactate (300 mg/kg). immunosuppressed mice induced by cyclophosphamide (CTX), evaluated immune regulation The result showed that restored body weight, boosted organ index, repaired...