Alex Shayo
A5084080548- Malaria Research and Control
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Research on Leishmaniasis Studies
- Hepatitis C virus research
- Aquaculture disease management and microbiota
- Parasites and Host Interactions
- Hepatitis Viruses Studies and Epidemiology
- Multiple Myeloma Research and Treatments
- Trypanosoma species research and implications
Université Félix Houphouët-Boigny
2023
Nelson Mandela African Institution of Science and Technology
2014-2021
The University of Dodoma
2015
The World Health Organization recommends that regular efficacy monitoring should be undertaken by all malaria endemic countries have deployed artemisinin combination therapy (ACT). Although ACT is still efficacious for treatment of uncomplicated malaria, resistance has been reported in South East Asia suggesting surveillance needs to intensified countries. This study assessed the and safety artemether-lumefantrine (AL) falciparum Muheza district north-eastern Tanzania, an area where...
Plasmodium falciparum resistance to anti-malarials is a major drawback in effective malaria control and elimination globally. Artemisinin-combination therapy (ACT) currently the key first-line treatment for uncomplicated malaria. genetic signatures at pfmdr-1, pfcrt, pfubp-1 loci are known modulate vivo vitro parasite response ACT. The objective of this study was assess distribution these gene markers isolates collected from different transmission intensity Ethiopia Tanzania. clinical were...
Abstract Artemisinin resistant Plasmodium falciparum is advancing across Southeast Asia in a soft selective sweep involving at least 20 independent kelch13 mutations. In large global survey, we find that mutations which cause resistance are present low frequency Africa. We show African have originated locally, and shows normal variation pattern relative to other genes Africa, whereas there great excess of non-synonymous mutations, many radical amino-acid changes. Thus, not currently...