A5057121548- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- Plant Virus Research Studies
- Viral Infections and Immunology Research
- Dental Radiography and Imaging
- Endodontics and Root Canal Treatments
- Viral Infections and Vectors
- Oral microbiology and periodontitis research
- Turtle Biology and Conservation
- Rabies epidemiology and control
- Poxvirus research and outbreaks
- Veterinary medicine and infectious diseases
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Antibiotic Resistance in Bacteria
- Virology and Viral Diseases
- Clostridium difficile and Clostridium perfringens research
- Bacillus and Francisella bacterial research
- SARS-CoV-2 and COVID-19 Research
- Bat Biology and Ecology Studies
- Identification and Quantification in Food
University of Bari Aldo Moro
2018-2025
Istituto Zooprofilattico Sperimentale del Mezzogiorno
2022
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2022
National Research Centre
2022
Feline coronavirus (FCoV) is an alphacoronavirus (αCoV) that causes moderate or chronic asymptomatic infection in cats. However, a single infected cat, FCoV can modify its cellular tropism by acquiring the ability to infect macrophages, resulting development of feline infectious peritonitis (FIP). In this context, restrain impact infection, scientific research has focused attention on antiviral therapies involving novel mechanisms action. Recent studies have demonstrated aryl hydrocarbon...
Abstract Hepadnaviruses infect several animal species. The prototype species, human hepatitis B virus (HBV), increases the risk of liver diseases and may cause cirrhosis hepatocellular carcinoma. Recently a novel hepadnavirus, similar to HBV, has been identified through transcriptomics studies in domestic cat with large cell lymphoma Australia. Herewith, collection 390 feline serum samples was screened for hepadnavirus. Overall, 10.8% sera significantly higher prevalence (17.8%) animals...
Noroviruses are a major cause of acute gastroenteritis, often transmitted through contaminated food and water. In this study, lemon juice (LJ), rich in citric acid (CA) flavonoids, was tested against Feline Calicivirus (FCV), used as surrogate human norovirus. Significant virucidal activity observed for pure LJ (pH = 2.3), with reduction viral titers high 4.50 log10 TCID50/50 µL after 30 s complete inactivation 1 min. also showed limited at dilution 1:2000 6.7), titer 0.75 µL. CA (at the...
Two feral cats (from the same colony) were presented to veterinary clinic for weakness, weight loss, and anorexia. The part of a study on feline hepatotropic viruses (collection A, 43 animals). On metaviromic investigation, parvoviral reads identified in sera two cats. parvovirus genome was 5.3 kb long with an organization similar other members Erythroparvovirus genus. In ORF1 (nonstructural proteins) ORF2 (VP1/VP2 precursor) virus displayed 43.1% 49.1% nucleotide identity human B19, 48.9%...
CDV has been detected in a wide range of domestic and wild animal also Italy it is highly prone to cross-species transmission, therefore representing significant health risk. In this study the presence other coinfecting selected viruses, carnivorans family Mustelidae Canidae rodents Hystricidae, collected Southern (Campania region), 2022–2024, was investigated. Over period 3 years (2022–2024), tissue samples from 136 animals including stone martens, porcupines, otters, wolves, badgers foxes...
A novel orthohepadnavirus (domestic cat hepadnavirus [DCH]) similar to human hepatitis B virus has been recently detected in serum and liver samples from domestic cats with chronic hepatocellular carcinoma. Molecular investigations by independent research groups around the world have revealed positivity rates ranging 6.5% 12.5% blood up 14.0% tissue. In this study, we screened an age-stratified collection of feline sera (n = 256) using antibody detection enzyme-linked immunosorbent assay...
Abstract Canine parvovirus and feline panleukopenia virus (FPV) are variants of Carnivore protoparvovirus 1. We identified characterized FPV in dogs from Italy Egypt using genomic sequencing phylogenetic analyses. Cost-effective strategies should be used to monitor interspecies spread, evolution dynamics, potential host jumping FPV.
Hepadnaviruses have been identified in several animal species. The hepadnavirus prototype, human hepatitis B virus (HBV), is a major public health problem associated with chronic liver diseases and hepatocellular carcinoma. Recently, novel hepadnavirus, similar to HBV, was domestic cats. Since pathogens can be shared between cats dogs, we hypothesized that dogs could also harbor hepadnaviruses tested collection of canine sera multiple molecular strategies. Overall, DNA 6.3% (40/635) serum...
Feline calicivirus (FCV) is a common viral pathogen found in domestic cats. FCV highly contagious and demonstrates high genetic variability. Upper respiratory tract disease, oral ulcerations, salivation, gingivitis-stomatitis have been regarded as typical clinical signs of infection. Ulcerative dermatitis, abortion, severe pneumonia, enteritis, chronic stomatitis, virulent systemic disease reported more sporadically. Limping syndrome has also described either naturally or experimentally...
Starting from June 2022, increased mortality associated with enteric signs was reported in European hedgehogs (Erinaceus europaeus) recovered at a regional wildlife rescue center, Apulia, Italy. Cases of disease were observed until the end breeding season, despite biosafety measures. A novel parvovirus identified using metaviromic, and parvovirus-like particles stools on electron microscopy observation. The virus detected fecal samples all animals tested (n = 9) internal organs (liver,...
Norovirus (NoV) causes serious gastrointestinal disease worldwide and is regarded as an important foodborne pathogen. Due the difficulties of in vitro cultivation for human NoV, alternative caliciviruses (i.e., feline calicivirus, FCV, or murine NoV) have long been used surrogates assessment efficacy antivirals. Essential oils (EOs) are natural compounds that displayed antimicrobial antioxidant properties.We report virucidal four EOs, Melissa officinalis L. EO (MEO), Thymus vulgaris (TEO),...
The hepatitis C virus (HCV) is a major hepatotropic that affects humans with increased risk of developing hepatocellular carcinoma. bovine viral diarrhea (BVDV) causes abortion, calf mortality and poor reproductive performance in cattle. Due the difficulties vitro cultivation for HCV, BVDV has been used as surrogate assessment efficacy antivirals. Essential oils (EOs) display antiviral virucidal activity on several pathogens. In this study, five EOs, Salvia officinalis L. EO (SEO), Melissa...
Human astroviruses (AstVs) are usually associated with acute gastroenteritis. In recent years, atypical animal-like AstVs have been identified, but their pathogenic role in humans has not determined. Starting from 2010, there a growing evidence that may also be encephalitis human and animal hosts. Some AstV strains (VA1, MLB1/MLB2) display neurotropic potential, as they repeatedly identified patients AstV-related encephalitis, chiefly immunosuppressed individuals. this study, VA1-like was...
A 3-year-old female stray, shorthair cat, with clinical signs and serum chemistry markers indicative of hepatic disease, was diagnosed domestic cat hepadnavirus (DCH) infection. Coupling molecular serological data, the infection seemingly contextualized into a chronic phase, since IgM anti-core antibodies, marker early-stage Hepatitis B Virus (HBV) infection, were not detected. However, possessed IgG anti-core, common indicator HBV in human patients did show seroconversion to anti-DCH...
Kobuviruses (KoVs) are a group of small, non-enveloped RNA viruses classified in the genus
Adenoviruses are important pathogens of humans and animals. Bats have been recognized as potential reservoirs novel viruses, with some viruses being regarded a possible zoonotic threat to humans. In this study, we report the detection analysis adenoviruses from different bat species in northern Italy. Upon sequence phylogenetic analysis, based on short diagnostic fragment highly-conserved DNA polymerase gene, identified candidate adenovirus species, including an avian-like strain. An isolate...