A5076671736- Sperm and Testicular Function
- Functional Brain Connectivity Studies
- Poisoning and overdose treatments
- Reproductive Biology and Fertility
- Effects of Environmental Stressors on Livestock
- Microbial Inactivation Methods
- Fungal and yeast genetics research
- Visual perception and processing mechanisms
- Reproductive Physiology in Livestock
- Neural dynamics and brain function
- Listeria monocytogenes in Food Safety
- Plant Toxicity and Pharmacological Properties
- RNA Research and Splicing
- Data Visualization and Analytics
- Mental Health and Psychiatry
- Psychedelics and Drug Studies
- Nuclear Structure and Function
- Spatial Cognition and Navigation
- Neural and Behavioral Psychology Studies
- 3D Surveying and Cultural Heritage
- Consumer Market Behavior and Pricing
- Urinary Tract Infections Management
- Food Safety and Hygiene
- Memory and Neural Mechanisms
- Image Retrieval and Classification Techniques
University of Newcastle Australia
2022-2024
University of Maryland, Baltimore
2016-2020
University of Connecticut
2020
Old Dominion University
2011
ABSTRACT Herein, we compare the different experimental regimes used to induce testicular heat stress and summarise their impact on sperm production male fertility. Irrespective of protocol used, scrotal causes loss production. This is first seen 1–2 weeks post stress, peaking 4–5 thereafter. The higher temperature, or longer duration heat, more pronounced germ cell becomes, within extreme cases this leads azoospermia. second, often underappreciated hyperthermia poor‐quality spermatozoa....
Objective: To understand the immediate impact that testicular heat stress has on isolated populations of precursor male germ cells including Spermatocytes and Spermatids. Design: Mice were given pre-cursor immediately isolated. RNA sequencing was performed validated using qPCR. Subjects: This work carried out in adult CD1 mice. Results: Using next-generation 134 differentially expressed transcripts found to be upon exposure hyperthermia, 93% which upregulated. In addition, hyperthermia...
NITROFURANTOIN is frequently used for short and long term treatment of urinary tract infections. As with many drugs, various types allergic or toxic reactions have occurred, the most serious which anaphylactic shock.<sup>1</sup> An unusual reaction to nitrofurantoin consisting pulmonary infiltration pleural effusion was reported by Israel Diamond in May, 1962.<sup>2</sup>Three other reports appeared foreign literature.<sup>3-5</sup> Because its rarity occurrence, but alarming picture that it...
Abstract Using semen data from 1271 ejaculates (79 different bulls, 11 breeds) we have investigated the variability of quality in cattle living sub-tropical conditions. Modelling shows definitive evidence seasonal variation. Semen same bulls had a 90% “pass rate” for cryopreservation purposes winter, dropping to less than 50% summer. Notably, individual could be classified as either “heat-tolerant” (produce good spermatozoa all year regardless temperature) or “heat-sensitive” (only produce...
Abstract Testicular heat stress is a well-known and well-described phenomenon that occurs in mammals possess scrotum. Different models to induce testicular hyperthermia, such as surgical cryptorchidism, hot water bath, scrotal insulation or increased environmental temperature have all shown spermatocytes spermatids are unambiguously affected by high temperature, resulting poor sperm production weeks later. The testis appears be very sensitive fluctuations, even small changes temperatures...
Male subfertility or infertility is a common condition often characterized by men producing low number of sperm with poor quality. To gain insight into this condition, we performed quantitative proteomic analysis semen samples obtained from infertile and fertile men. At least 6 proteins showed significant differences in regulation alternatively spliced isoforms. investigate link between aberrant alternative splicing production poor-quality spermatozoa, overexpressed the hnrnpH/F-orthologue...
Abstract Testicular heat stress is a well-known and well-described phenomenon that occurs in mammals possess scrotum. Different models to induce testicular hyperthermia, such as surgical cryptorchidism, hot water bath, scrotal insulation or increased environmental temperature have all shown spermatocytes spermatids are unambiguously affected by high temperature, resulting poor sperm production weeks later. The testis appears be very sensitive fluctuations, even small changes temperatures...
Abstract The family of CDC2-like kinases (CLKs) play a crucial role in regulating alternative splicing (AS), process fundamental to eukaryotic gene expression and adaptation. Of particular interest, these enzymes exhibit unique responsiveness minor temperature shifts, enabling them modulate AS accordingly. Dysregulated CLK is linked wide variety human diseases, establishing as promising therapeutic targets. Despite the importance CLKs, limited research has explored genetic functional...
Recent research suggests that people with schizophrenia (PSZ) tend to hyperfocus on goal-relevant information, which is typically deleterious task performance. However, performance decrements can be difficult interpret because many different factors lead impaired Here we show hyperfocusing information actually a more optimal pattern of attentional guidance during visual search in PSZ than healthy control subjects (HCS). We recorded eye movements participants searched for Landolt-C target...
Abstract A key challenge for years to come is feeding a rapidly growing human population, whilst lowering the overall costs and impact on environment. In addition, as global temperatures increase, natural resources must be utilised basic means overcome climate-related issues. To this end, improvements bull fertility are recognised major mechanism that address both economical environmental balance. Using semen data from 1271 ejaculates (79 different bull, 11 breeds) we have investigated...
Male subfertility or infertility is a common condition often characterized by men producing low number of sperm with poor quality. To gain insight into this condition, we performed quantitative proteomic analysis semen samples obtained from infertile and fertile men. From dataset, 369 proteins showed consistent changes between the groups. Gene ontology revealed that in nucleosome located alternative splicing were ranked highest. This included several exon skipping regulators (hnrnpH/F,...
During daily functioning, a person makes thousands of goal-driven saccades to align the receptor-rich fovea with task-relevant information from visual field. People schizophrenia (PSZ) are known be impaired at and recent work our group suggests tendency hyperfocus on subset might contribute such dysfunction. Consistent related hypothesis that is associated spatial hyperfocusing, Luck et al. (2014) found parafoveal distractor presented task-irrelevant location (either above or below central...
It is known that people divide spatial regions into categories to enhance perception and interaction with the environment. Boundaries or landmarks are affect memory target localization due development of biases related these 'categories'. Spatial recall tasks widely used assess developmental changes in adult children have shown towards away from a visible boundary. Although working impairments among hallmark neurocognitive deficits observed schizophrenia, exact processes landmark effects...
An emerging model posits that perceptual inference deficits could lead to distorted internal models of the world, which then explain existence abnormal beliefs or delusions experienced by people with schizophrenia(PSZ). Here, we used motion perception tasks explore how construction environment are utilized unconsciously and automatically in uncertain circumstances predict disambiguate inputs guide decisions schizophrenia. We a random dot kinematogram algorithm developed Roitman & Shadlen...