A5101949276- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Optical Coherence Tomography Applications
- Obsessive-Compulsive Spectrum Disorders
- Digital Holography and Microscopy
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Attention Deficit Hyperactivity Disorder
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Sleep and related disorders
- Advanced Fluorescence Microscopy Techniques
- Retinal Development and Disorders
- Epigenetics and DNA Methylation
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Genetic Neurodegenerative Diseases
- Congenital heart defects research
- Optical measurement and interference techniques
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Treatment of Major Depression
- Circadian rhythm and melatonin
Korea University
2009-2024
Seoul National University
2023
Massachusetts Institute of Technology
2006
Abstract Compulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying not clearly defined. Here we show that basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to manifestation compulsive-like behaviors. We revealed BLA neurons projecting DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with neuronal population responds aversive predator stress, widely used anxiogenic stressor. Specific...
Abstract Background Astrocytes regulate neuronal excitability and synaptic activity by releasing gliotransmitters such as glutamate. Our recent study demonstrated that astrocytes release glutamate upon GPCR activation via Ca 2+ activated anion channel, Bestrophin-1 (Best1). The target of Best1-mediated astrocytic has been shown to be the NMDA receptors (NMDAR). However, whether it targets synaptically or extra-synaptically localized NMDAR is not known. Findings We recorded spontaneous...
Long-lasting, drug-induced adaptations within the nucleus accumbens (NAc) have been proposed to contribute drug-mediated addictive behaviors. Here we used an optogenetic approach examine role of NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D2Rs) in cocaine-induced behavioral sensitization. Adeno-associated viral vectors encoding channelrhodopsin-2 (ChR2) were delivered into D2R-Cre transgenic mice. This allowed us selectively photostimulate D2R-MSNs NAc. form local...
Many psychiatric disorders accompany deficits in cognitive functions and synaptic plasticity, abnormal lipid modifications of neuronal proteins are associated with their pathophysiology. Lipid modifications, including palmitoylation myristoylation, play crucial roles the subcellular localization trafficking proteins. Cyclin Y (CCNY), enriched postsynaptic compartment, acts as an inhibitory modulator functional structural long-term potentiation (LTP) hippocampal neurons. However, cellular...
Nerve fibers play a critical role in the propagation of electrical impulses nervous system, and several studies have demonstrated their chemical properties. However, because lack practical biophotonics techniques, most optical properties these are unknown. Herein, we propose demonstrate novel method precisely measuring dispersion an individual nerve fiber striatal neurons, using single-shot label-free triple-wavelength diffraction phase interferometer employing Cauchy coefficients refractive...
Stress is a critical precipitating factor for major depression. However, individual responses to the same stressor vary widely, possibly owing variations in stress resilience. Nevertheless, factors that determine susceptibility and resilience remain poorly understood. Orexin neurons have been implicated control of stress-induced arousal. Therefore, we investigated whether orexin-expressing are involved regulation male mice. We found level c-fos expression was significantly different...
Synchronous scanning of multiple objects is essential to health monitoring cells with high reliability. In general, fixed optical resolution in a total area larger than the sensor size camera requires asynchronous scanning; therefore, recorded images different scanned areas are asynchronous. We have developed novel single-shot triple field view (FOV) interferometric technique that rectifies this problem and effect high-frequency noise due motorized components utilized extend imaging area....
The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive negative reinforcement appear to shape our behavioral adaptation modulating function ganglia. Here, we examined a transgenic mouse line (G2CT) which synaptic transmissions onto medium spiny neurons (MSNs) are depressed. We found that level collaterals from direct pathway MSNs external segment globus pallidus (GPe) ('bridging...
Abstract Obsessive compulsive disorder (OCD) is a debilitating neuropsychiatric condition characterized by obsessions and compulsions. Despite the crucial role of amygdala in anxiety, its OCD remains unclear. We found that basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to manifestation OCD-related behaviors. revealed BLA neurons projecting DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with neuronal population responds aversive...
Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at TPH1 locus have been implicated pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated possible relationship between A218C polymorphism amygdala response to negative facial stimuli 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed polymerase chain reaction. We found a significant...