A5087819578- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Cardiovascular Function and Risk Factors
- Hepatitis Viruses Studies and Epidemiology
- Sepsis Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Biliary and Gastrointestinal Fistulas
- Healthcare Policy and Management
- Bariatric Surgery and Outcomes
- Frailty in Older Adults
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebrospinal fluid and hydrocephalus
- Innovations in Medical Education
- Hemodynamic Monitoring and Therapy
- Endoplasmic Reticulum Stress and Disease
- Opioid Use Disorder Treatment
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
University of Michigan
2013-2019
NIHR Clinical Research Network
2019
Lymphatic Education & Research Network
2019
Michigan United
2017-2019
Michigan Medicine
2014-2019
A. Alfred Taubman Health Care Center
2014-2019
Johns Hopkins University
2013-2016
Johns Hopkins Hospital
2013-2016
Johns Hopkins Medicine
2016
Nonalcoholic steatohepatitis (NASH) cirrhosis is the fastest growing indication for liver transplantation (LT) in United States. We aimed to determine temporal trend behind rise obesity and NASH‐related additions LT waitlist States make projections future NASH burden on waitlist. used data from Organ Procurement Transplantation Network database 2000 2014 obtain number of additions. The obese population was estimated using U.S. Census Bureau National Health Nutrition Examination Survey. Based...
Despite effective treatment for chronic hepatitis C, deficiencies in diagnosis and access to care preclude disease elimination. Screening of baby boomers remains low. The aims this study were assess the impact an electronic health record–based prompt on C virus (HCV) screening rates primary specialty among those newly diagnosed. We implemented “best practice advisory” (BPA) that prompted providers perform HCV patients seen clinic (1) born between 1945 1965, (2) who lacked a prior infection,...
<h3>Importance</h3> Universal screening of patients with newly diagnosed cancer for hepatitis B virus (HBV), C (HCV), and HIV is not routine in oncology practice, experts disagree about whether universal should be performed. <h3>Objective</h3> To estimate the prevalence HBV, HCV, infection among persons cancer. <h3>Design, Setting, Participants</h3> Multicenter prospective cohort study (ie, identified within 120 days diagnosis) at 9 academic community institutions affiliated SWOG (formerly...
Human immunodeficiency virus (HIV)/hepatitis C (HCV) coinfection is associated with progressive liver disease. However, the rate of progression variable and ability to differentiate patients stable versus HCV disease limited. The objective this study was assess incidence risk factors for fibrosis in a prospective cohort coinfected patients. Overall, 435 biopsy pairs from 282 without cirrhosis were analyzed. Biopsies scored according METAVIR system by single pathologist blind sequence....
Background Machine learning (ML) algorithms provide effective ways to build prediction models using longitudinal information given their capacity incorporate numerous predictor variables without compromising the accuracy of risk prediction. Clinical in chronic hepatitis C virus (CHC) can be challenging due non-linear nature disease progression. We developed and compared two ML predict cirrhosis development a large CHC-infected cohort data. Methods findings used national Veterans Health...
Current treatment for chronic hepatitis C (CHC) is highly efficacious, well-tolerated, and of short duration the majority patients. Despite dramatic advances in therapy, there remain several barriers to disease eradication. These include deficiencies screening, diagnosis, access care, high cost direct-acting antiviral medications. In addition, incident cases reinfection associated with injection drug use contribute persistent worldwide burden. This article will review current CHC treatments,...
Existing predictive models of risk disease progression in chronic hepatitis C have limited accuracy. The aim this study was to improve upon existing by applying novel statistical methods that incorporate longitudinal data. Patients the Hepatitis Antiviral Long-term Treatment Against Cirrhosis trial were analyzed. Outcomes interest (1) fibrosis (increase two or more Ishak stages) and (2) liver-related clinical outcomes (liver-related death, hepatic decompensation, hepatocellular carcinoma,...
Frailty is increasingly recognized as a predictor of poor outcomes in solid organ transplantation. The most widely utilized frailty tool, the Fried Index (FFI), includes patient-reported exhaustion, weight loss, and physical activity well measured walk speed handgrip. Although hepatic encephalopathy (HE) common among liver transplant candidates, data are lacking regarding its impact on interpretation frailty. We prospectively enrolled 685 patients with cirrhosis during their evaluation,...
Objective Assessing risk of adverse outcomes among patients with chronic liver disease has been challenging due to non-linear progression. We previously developed accurate prediction models for fibrosis progression and clinical advanced hepatitis C (CHC). The primary aim this study was validate a heterogeneous patient cohort. Design Adults CHC ≥3 years follow-up without hepatic decompensation, hepatocellular carcinoma (HCC), transplant (LT), HBV or HIV co-infection at presentation were...
Objective Data on patterns and correlates of opioid benzodiazepines prescriptions among patients with chronic conditions are limited. Given a diminished capacity for hepatic clearance, cirrhosis represent high risk group use. The aim this study was to characterise the prescription opioid, benzodiazepine dual drug individuals common diseases. Design Analysis Truven Marketscan database evaluate coverage (n=169,181), hepatitis C without (n=210 191), congestive heart failure (n=766 840) or...
Summary Background Lifestyle interventions are first‐line therapy for non‐alcoholic fatty liver disease (NAFLD). Aims To examine the prevalence of NAFLD among participants University Michigan Metabolic Fitness (MetFit) Programme and to assess impact this programme on weight, metabolic liver‐related parameters patients with without NAFLD. Methods Adults who completed between 2008 2016 were included. Clinical laboratory data collected at enrolment, 12 24 weeks. was defined based biopsy,...
Hemobilia represents an uncommon cause of gastrointestinal bleeding that can present both diagnostic and therapeutic challenges. The evaluation hemobilia typically involves cross-sectional imaging endoscopic retrograde cholangiopancreatography (ERCP). There is limited data regarding the utility ultrasound (EUS) in hemobilia. We a case hepatic artery pseudoaneurysm as etiology was detected via EUS only. conclude serve important tool obscure hemobilia, especially cases where imaging, ERCP,...
BACKGROUND:Cardiopulmonary (CP) outcomes remain a leading cause of morbidity and mortality following liver transplantation (LT). The optimal CP risk stratification LT candidates remains unclear. aim this study was to evaluate the association pre-LT transthoracic echocardiogram (TTE) findings 6-month post-LT outcomes. MATERIAL AND METHODS:This retrospective review analyzed adults who underwent LT, comparing those died within 6 months (cases; n=38) with age- sex-matched patients survived >6...
Accuracy of risk assessments for clinical outcomes in patients with chronic liver disease has been limited given the nonlinear nature progression. Longitudinal prediction models may more accurately capture this dynamic risk. The aim study was to construct accurate short- and long-term progression hepatitis C by incorporating longitudinal data. Data from Hepatitis Antiviral Long-term Treatment Against Cirrhosis trial were analysed (n = 533 training cohort; n 517 validation cohort). Outcomes...
Metabolic syndrome is associated with an increased risk of cardiovascular disease and multiple other chronic health conditions. Studies have demonstrated the effectiveness structured diet exercise programs to improve components metabolic syndrome. The durability these benefits after program completion unclear. aim this study was evaluate trends in factors 12 months post a 12- or 24-week lifestyle intervention program.Individuals were referred Fitness program, consisting weekly nutrition...
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