A5019641117- Plant Reproductive Biology
- Microbial Metabolic Engineering and Bioproduction
- Chromosomal and Genetic Variations
- Bacterial Genetics and Biotechnology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomics and Phylogenetic Studies
- Plant and animal studies
- Genomics and Rare Diseases
- Genetic diversity and population structure
- Epilepsy research and treatment
- Plant and Fungal Species Descriptions
- Microbial Natural Products and Biosynthesis
- CRISPR and Genetic Engineering
- Traditional Chinese Medicine Analysis
- Genetics and Neurodevelopmental Disorders
- Bryophyte Studies and Records
- Fetal and Pediatric Neurological Disorders
- Analytical Chemistry and Chromatography
- Chemical Reactions and Isotopes
- Reproductive System and Pregnancy
- Neurological and metabolic disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Glioma Diagnosis and Treatment
- Plant Diversity and Evolution
- Enzyme Catalysis and Immobilization
Tianjin University of Science and Technology
2012-2025
Sichuan University
2020-2025
West China Second University Hospital of Sichuan University
2021-2025
Second People’s Hospital of Yibin
2025
University of Toronto
2020-2024
Taizhou University
2024
Shanghai Normal University
2024
Shandong University
2021-2022
Nanjing Medical University
2020
Nanjing University
2020
Zika virus (ZIKV) infection can lead to neurological complications and fetal defects, it has attracted global public health concerns. Effective treatment for ZIKV remains elusive, a preventative vaccine is not yet available. Therapeutics fetuses need overcome placenta barriers reach the require higher safety standards. In present study, we engineered mammalian extracellular vesicles (EVs) deliver host restriction factor, interferon-induced transmembrane protein 3 (IFITM3), of infection. Our...
Corynebacterium glutamicum has industrial track records for producing a variety of valuable products such as amino acids. Although CRISPR-based genome editing technologies have undergone immense developments in recent years, the suicide-plasmid-based approaches are still predominant C. manipulation. It is crucial to develop simple and efficient CRISPR method glutamicum.In this study, we developed RecombinAtion Prior Induced Double-strand-break (RAPID) technology glutamicum, Cpf1 cleavage was...
There is growing evidence from diverse taxa for sex differences in the genomic landscape of recombination, but causes and consequences these remain poorly understood. Strong recombination dimorphism between sexes could have important implications dynamics chromosome evolution because low heterogametic can favour spread sexually antagonistic alleles. Here, we present a sex-specific linkage map revised genome assembly Rumex hastatulus provide first characterization dioecious plant. We data on...
Introduction: O'Donnell-Luria-Rodan syndrome was recently identified as an autosomal dominant systemic disorder caused by variants in KMT2E . It is characterized global developmental delay, some patients also exhibit autism, seizures, hypotonia, and/or feeding difficulties. Methods: Whole-exome sequencing of family trios were performed for two independent children with unexplained recurrent seizures and delay. Both cases having de novo We collected summarized the clinical data diagnosed them...
Abstract Sex chromosomes have evolved independently many times across eukaryotes. Despite a considerable body of literature on the evolution sex chromosomes, causes and consequences variation in formation, degeneration, turnover remain poorly understood. Comparative approaches groups with sexual system can be valuable for understanding these questions. Plants are well-suited to such comparative studies, lineages containing relatively recent origins dioecy as well hermaphroditic close...
Oenanthe javanica (Bl.) DC. (Apiaceae) is a herbaceous species naturally distributed in China. The complete chloroplast genome sequence of was generated by de novo assembly using whole next generation sequencing data. 154,246 bp length and divided into four distinct regions, such as large single copy region (84,142 bp), small (17,238 bp) pair inverted repeat regions (26,433 26,433 bp). annotation predicted total 123 genes, including 85 protein-coding 36 tRNA 8 rRNA genes. Phylogenetic...
Abstract Background Epilepsy is one of the most common chronic neurological diseases. Despite great variety and prevalence antiepileptic drug treatments, one-third epilepsies remain resistant. The frontal lobe extensive, seizures are difficult to locate, which increases difficulty preoperative localization epileptogenic zone. Case presentation Two previously healthy girls with refractory epilepsy showed significant perfusion abnormalities in right using cerebral blood (CBF) quantitative...
Blume is an endangered species on the IUCN Red List. In this study, we reported complete chloroplast (cp) genome of
Abstract The maintenance of genetic variation by balancing selection is considerable interest to evolutionary biologists. An important but understudied potential driver antagonistic pleiotropy between diploid and haploid stages the plant life cycle. Despite sharing a common genome, sporophytes (2n) gametophytes (n) may undergo differential or even opposing selection. Theoretical work suggests can generate maintain variation. for far-reaching consequences gametophytic selection, empirical...
Abstract Sex chromosomes have evolved independently many times across eukaryotes. Despite a considerable body of literature on sex chromosome evolution, the causes and consequences variation in their formation, degeneration, turnover remain poorly understood. Chromosomal rearrangements are thought to play an important role these processes by promoting or extending suppression recombination chromosomes. may also contribute barriers gene flow, limiting introgression among species. Comparative...
Separation power was limited when the conventional high-performance liquid chromatography (HPLC) fingerprinting method based on a single column used to analyze very complex traditional Chinese medicine (TCM) preparations. In this research, novel HPLC switching technology by using pump established for evaluating quality of Tianmeng oral (TMOL). Twelve batches TMOL samples were constructing fingerprints. Compared with 16 common peaks in column, 25 achieved two columns connected through six-way...
Summary There is growing evidence across diverse taxa for sex differences in the genomic landscape of recombination, but causes and consequences these remain poorly understood. Strong recombination dimorphism between sexes could have important implications dynamics chromosome evolution turnover because low heterogametic can help favour spread sexually antagonistic alleles. Here, we present a sex-specific linkage map revised genome assembly Rumex hastatulus , representing first...
The GATOR1 complex is located at the upstream of mTOR signal pathway and can regulate function mTORC1. Genetic variants are closely associated with epilepsy, developmental delay, cerebral cortical malformation tumor. This article has reviewed research progress in diseases genetic complex, aim to provide a reference for diagnosis treatment such patients.
Abstract Corynebacterium glutamicum has industrial track records for producing a variety of valuable products such as amino acids. Although CRISPR-based genome editing technologies have undergone immense developments in recent years, the suicide-plasmid-based approaches are still predominant C. manipulation. In this study, we developed RecombinAtion Prior to Induced Double-strand-break (RAPID) technology , Cpf1 cleavage was found disrupt RecET-mediated homologous recombination (HR) donor...