A5058429994- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Bioactive natural compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Flavonoids in Medical Research
- Medicinal Plants and Neuroprotection
- Trypanosoma species research and implications
- Plant biochemistry and biosynthesis
- Research on Leishmaniasis Studies
- Biological and pharmacological studies of plants
- Ethnobotanical and Medicinal Plants Studies
- Saffron Plant Research Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Plant Toxicity and Pharmacological Properties
- Natural Compound Pharmacology Studies
- Plant chemical constituents analysis
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Bioactivity Studies
- Piperaceae Chemical and Biological Studies
- Chemical synthesis and alkaloids
University of Basel
2017-2024
Max Zeller Söhne (Switzerland)
2024
Institut de Chimie de Clermont-Ferrand
2017-2019
Université Clermont Auvergne
2017
Centre National de la Recherche Scientifique
2017
Sigma Clermont
2017
A library of extracts from plants used in Chinese Traditional Medicine was screened for inhibition T lymphocyte proliferation. An ethyl acetate extract aerial parts Artemisia argyi showed promising activity and submitted to HPLC-based profiling track the active compounds. From most time window, three guaianolides (1, 2, 5) two seco-tanapartholides (3 4) were identified and, a less five new sesquiterpene lactones (8-11, 17), along with six known flavonoids. The absolute configurations...
Abstract As part of a screening for new antiparasitic natural products from Iranian plants, n-hexane and ethyl acetate extracts the aerial parts Perovskia abrotanoides were found to exhibit strong inhibitory activity against Trypanosoma brucei rhodesiense Leishmania donovani. The was tracked by high-performance liquid chromatography (HPLC)-based profiling. Preparative isolation combination silica gel column HPLC afforded 17 diterpenoids (1–17), including 14 abietane-, two icetexane-, one...
A naringenin derivative, isolated from Cyclopia genistoides, a bitter tasting herbal tea, especially when in green (unoxidized) form, was identified as (2S)-5-[α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyloxy]naringenin (1). The compound partially epimerizes to (2R)-5-[α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyloxy]naringenin (2) heated at different temperatures (80, 90, 100, 110, and 120 °C) for prolonged period phosphate buffer pH 5. fractional conversion model predicted the decrease...
A screening of Sudanese medicinal plants for antiprotozoal activities revealed that the chloroform and water fractions ethanolic root extract
In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts fruits Croton gratissimus var. and stems Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against axenically grown Leishmania donovani amastigotes. This antileishmanial was localized HPLC-based profiling. Targeted preparative isolation afforded flavonoids 1-6, 3-methoxy-4-hydroxybenzoic acid (7),...
A surface extract of the aerial parts Salvia tingitana afforded a nor-sesterterpenoid (1) and eight new sesterterpenoids (2–̵9), along with five known sesterterpenoids, labdane one abietane diterpenoid, sesquiterpenoid, four flavonoids. The structures compounds were established by 1D 2D NMR spectroscopy, HRESIMS, VCD data Mosher's esters analysis. antimicrobial activity was evaluated against 30 human pathogens including 27 clinical strains three isolates marine origin for their possible...
Some plants used in Traditional Chinese Medicine serve as treatment for disease states where a suppression of the cellular immune response is desired. However, compounds responsible immunosuppressant effects these are not necessarily known. The roots Scutellaria baicalensis, one most promising identified previous screening, were tracked by HPLC activity profiling and concomitant on-line spectroscopic analysis. Compounds then isolated preparative chromatography, structures elucidated methods....
Fractionation of the n-hexane extract Salvia hydrangea afforded seven isoprenoids including six new compounds (1–6) and salvadione A (7). Their structures were established by comprehensive spectroscopic spectrometric data analysis (1D 2D NMR, HRMS). The absolute configuration (7) was single-crystal X-ray diffraction with Cu/Kα radiation. In addition, all determined electronic circular dichroism spectroscopy. biosynthetic pathway for formation scaffold 1 is proposed. antiprotozoal activity...
In a screening of Iranian plants for antiprotozoal activity dichlomethane extract from the aerial parts Helichrysum oocephalum showed in vitro against Plasmodium falciparum and Leishmania donovani, with IC50 values 4.01 ± 0.50 5.08 0.07 μg/mL, respectively. The was tracked by HPLC-based profiling, subsequent targeted preparative isolation afforded 24 compounds, including pyrones 22–24, phloroglucinol derivatives 12–19, compounds containing both structural motifs (1–11, 20, 21). Of these, 15...
Globally, more than six million people are infected with Trypanosoma cruzi, the causative protozoan parasite of vector-borne Chagas disease (CD). We conducted a cross-sectional ethnopharmacological field study in Bolivia among different ethnic groups where CD is hyperendemic. A total 775 extracts botanical drugs used context and from unrelated indications Mediterranean De Materia Medica compiled by Dioscorides two thousand years ago were profiled multidimensional assay uncovering...
In a screening of an extract library from plants used in Traditional Chinese Medicine the MeOH Toddalia asiatica inhibited proliferation human primary T cells with IC50 25.8 μg/mL. Activity was tracked by HPLC activity profiling, and total 15 compounds were characterized. Three compounds, toddalic acid (6) both enantiomers (7a 7b) toddanolic (7), new natural products, two recently published (2′R)-toddalolactone 3′-O-β-d-glucopyranoside (10) (2′S)-toddalolactone 2′-O-β-d-glucopyranoside (11),...
The aims of the present study were (i) to characterize dichloromethane extract fresh aerial parts S. somalensis, cultivated in Liguria (Italy), (ii) quantify carnosic acid production and (iii) find an eco-friendly alternative approach control diseases caused by phytopathogenic fungi. phytochemical investigation yielded several known terpenoids, as well a diterpene, 4α,9α-epoxy-2H-dibenzo[a,d]cyclohepten-7(5H)-one, not previously described plant metabolite before. results showed noteworthy...
Six undescribed polyacetylenic caffeoyl amides, five known flavones and three lignans were obtained from the fruits of North African traditional medicinal plant Ammodaucus leucotrichus Coss. & Durieu (Apiaceae). Isolation was achieved by a combination chromatographic methods, structures established extensive 1D 2D NMR spectroscopy, mass spectrometry, electronic circular dichroism, GC-MS analysis sugar derivatives. Polyacetylenic amides are reported for first time as specialized metabolites.
Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The family is known to contain a large variety of phenanthrenoids possessing especially cytotoxic properties. Luzula sylvatica, species, present Auvergne region France, but has never studied neither its phytochemical profile nor We investigated evaluated potential activities L. sylvatica aerial parts...
Phytochemical investigation of the n-hexane extract Stachys pilifera Benth. aerial parts resulted in isolation twelve compounds. Structures were elucidated using 1D and 2D-NMR, as well HRMS. The purified compounds identified one new monoglyceride (1), nine flavonoids (2–10), two steroidal cytotoxicity effects evaluated against breast cancer cell line (MCF-7) structural-activity relationship investigated.
Abstract Three new compounds ( 1 – 3 ) with unusual skeletons were isolated from the n -hexane extract of air-dried aerial parts Hypericum scabrum . Compound represents first example an esterified polycyclic polyprenylated acylphloroglucinol that features a unique tricyclo-[4.3.1.1 1,4 ]-undecane skeleton. 2 is fairly simple MPAP, but unexpected cycloheptane ring decorated prenyl substituents, and compound has 5,5-spiroketal lactone core. Their structures determined by extensive...
Corms are obtained as a byproduct during the cultivation of saffron (Crocus sativus). In project aimed at valorization this waste product, we observed that 70% EtOH extract corms and sugar-depleted MeOH fraction inhibited TNF-α/IFN-γ-induced secretion gene expression chemokines IL-8, MCP-1, RANTES in human HaCaT cells. The effects were part stronger than those positive control hydrocortisone. For preparative isolation, was partitioned between n-BuOH water. Separation n-BuOH-soluble by...
As part of a project aiming at the discovery environmentally friendly alternatives to copper in organic agriculture, 96% ethanolic extract from leaves Inga sapindoides showed potent inhibitory activity against grapevine downy mildew (Plasmopara viticola) vitro (MIC100 25 μg/mL). Separation n-BuOH soluble fraction by silica gel column chromatography followed combination RP18 and HILIC HPLC resulted isolation series bidesmosidic saponins characterized presence monoterpenoid unit attached...
Abstract Introduction The minor phenolic constituents of Cyclopia pubescens Eckl. & Zeyh. are unknown and one dimensional (1D) liquid chromatography (LC) is unable to provide sufficient separation. Methodology A two‐dimensional (2D) LC method incorporating normal‐phasehigh performance countercurrent (NP‐HPCCC) in the first dimension ( 1 D) reversed‐phase ultra‐high‐performance (RP‐UHPLC) as second 2 was developed. analytical HPCCC subsequently scaled up semi‐preparative mode fractions...
Cimicifuga racemosa (CR) extracts contain diverse constituents such as saponins. These saponins, which act a defense against herbivores and pathogens also show promise in treating human conditions heart failure, pain, hypercholesterolemia, cancer, inflammation. Some of these effects are mediated by activating AMP-dependent protein kinase (AMPK). Therefore, comprehensive screening for CR extract is highly desirable. Employing machine learning (ML) techniques Deep Neural Networks (DNN),...