A5008935005- Celiac Disease Research and Management
- Microscopic Colitis
- Eosinophilic Esophagitis
- Antimicrobial Peptides and Activities
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Helicobacter pylori-related gastroenterology studies
- Genetics and Neurodevelopmental Disorders
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Gastrointestinal disorders and treatments
- Autoimmune Bullous Skin Diseases
- Apelin-related biomedical research
- Virology and Viral Diseases
- Digestive system and related health
- Chronic Lymphocytic Leukemia Research
- Herpesvirus Infections and Treatments
- Genomic variations and chromosomal abnormalities
- Animal health and immunology
- Porphyrin Metabolism and Disorders
- Pancreatic function and diabetes
- Skin and Cellular Biology Research
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Vasculitis and related conditions
IRCCS Materno Infantile Burlo Garofolo
2009-2020
University of Trieste
2000-2011
University of Turin
1999
Abstract Background Association of the interleukin-23 receptor ( IL23R ) with inflammatory bowel disease (IBD) has been confirmed in several populations. also associates psoriasis, suggesting that gene may be an important candidate for many chronic diseases. Methods We studied association single-nucleotide variants IBD Swedish patients, both Crohn's (CD) and ulcerative colitis (UC) subsets. The same genetic were Finnish patients psoriasis or celiac disease, Hungarian Italian disease. Results...
Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory that expressed by most natural killer (NK) cells. The KIR gene is polymorphic: genomic diversity achieved through differences in content allelic polymorphism. number loci has been reported to vary among individuals, resulting different haplotypes. In this study we report the genotypic structure KIRs 217 unrelated healthy Italian individuals from 22 immunogenetics laboratories, located northern, central...
<h3>Background and objective</h3> Antitransglutaminase (anti-TG2) antibodies are synthesised in the intestine their presence seems predictive of future coeliac disease (CD). This study investigates whether mucosal represent an early stage gluten intolerance even absence intestinal damage serum anti-TG2 antibodies. <h3>Methods</h3> investigated 22 relatives patients with CD genetically predisposed to but negative for both abnormalities. Fifteen subjects were symptomatic seven asymptomatic....
Coeliac disease is caused by dietary gluten, triggering a chronic inflammation of the small intestine in genetically predisposed individuals. Recently, risk locus on chromosome 2q11–q12, harbouring interleukin 18 receptor accessory protein (IL18RAP) and three other genes, was suggested for coeliac disease. IL18 has been shown to play an important role T helper type 1 activity disease, making this highly interesting candidate. In study, two previously indicated variants at IL18RAP (rs13015714...
Abstract The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe (IgE > 85 kU/l against proteins a history of allergic reactions) who underwent specific oral immunotherapy (OIT), together 128 children mild recovered without OIT, compared the prevalence data our historical regarding healthy schoolchildren. Sixteen (5%) one (0.8%) tested positive both genetic serological markers, while among schoolchildren was 1%....
BACKGROUND: The influence of angiotensin converting enzyme (ACE) gene polymorphism on the progression primary IgA nephropathy (pIgAN) is still debated. Even though allele frequency was reported to be similar controls, in some studies D/D patients had a faster decline renal function and need dialysis. Since Henoch-Schoenlein purpura (HSP) nephritis considered systemic vasculitis with lesions indistinguishable from pIgAN, we investigated effect ACE presentation HSP IgAN. METHODS: We examined...
Objective The prevalence of coeliac disease (CD) in Vietnam is unknown. To fill this void, we assessed the serological markers CD autoimmunity a population children Hanoi. Setting outpatient blood drawing laboratory largest paediatric hospital North was used for study, which part an international project collaboration between Italy and Vietnam. Participants Children having drawn any reason were included. Exclusion criteria age younger than 2 years, acquired or congenital immune deficiency...
Summary New data suggest the involvement of rotavirus (RV) in triggering autoimmunity coeliac disease (CD) by molecular mimicry between human-transglutaminase protein and dodecapeptide (260-271 aa) RV VP7 (pVP7). To assess role onset CD, we measured anti-pVP7 antibodies sera children with CD control groups. We analysed serum samples 118 biopsy-proven patients 46 potential CD; 32 other gastrointestinal diseases; 107 no-CD blood donors. Using enzyme-linked immunosorbent assay (ELISA) assay,...
Antibodies against transglutaminase 6 (anti-TG6) have been implicated in neurological manifestations adult patients with genetic gluten intolerance, and it is unclear whether autoimmunity to TG6 develops following prolonged exposure. We measured the anti-TG6 children celiac disease (CD) at diagnosis time establish a correlation between these autoantibodies duration of investigated presence disorders.Anti-TG6 (IgA/IgG) were by ELISA sera biopsy-proven CD experiencing gastrointestinal...
A novel quantitative ELISA as accurate and reproducible tool to detect epidermal transglutaminase antibodies
An unbalance between Abs that recognize an autoantigen (idiotypes; IDs) and Igs bind such (anti-IDs) is considered a functional event in autoimmune disorders. We investigated the presence of ID/anti-ID network celiac disease (CD), condition which antitissue transglutaminase 2 (TG2) are suspected to contribute CD pathogenesis. To characterize ID side, we reproduced by vitro yeast display intestine-resident from control patients. These TG2-specific IDs were used identify potential anti-IDs...