A5042891818- Cardiac Valve Diseases and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Monoclonal and Polyclonal Antibodies Research
- Coronary Interventions and Diagnostics
- Carcinogens and Genotoxicity Assessment
- Soybean genetics and cultivation
- Bioactive Compounds and Antitumor Agents
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- DNA Repair Mechanisms
- Hypothalamic control of reproductive hormones
- Color Science and Applications
- Image Enhancement Techniques
- Frailty in Older Adults
- Acute Myocardial Infarction Research
- Effects and risks of endocrine disrupting chemicals
- Animal Virus Infections Studies
- Light effects on plants
- Aesthetic Perception and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Genetics and Plant Breeding
Kitano Hospital
2024
Kokura Memorial Hospital
2017-2024
Kyoto University
2014-2021
University of Rochester Medical Center
2015
Shizuoka Red Cross Hospital
2013
Chugai Pharma (United States)
2012
Saiseikai Matsuyama Hospital
2000
Ehime University
1981-1985
The semiquantitative Clinical Frailty Scale (CFS) is a simple tool to assess patients' frailty and has been shown correlate with mortality in elderly patients even when evaluated by nongeriatricians. aim of the current study was determine prognostic value CFS who underwent transcatheter aortic valve replacement.We utilized OCEAN (Optimized Catheter Valvular Intervention) Japanese multicenter registry review data 1215 replacement. Patients were categorized into 5 groups based on stages: 1-3,...
Shikonin derivatives are specialized lipophilic metabolites, secreted in abundant amounts from the root epidermal cells of Lithospermum erythrorhizon. Because they have anti-microbial activities, these compounds, which red naphthoquinone, thought to serve as a chemical barrier for plant roots. The mechanism by is, however, largely unknown. shikonin production system L. erythrorhizon is an excellent model studying compounds cells, because produced erythrorhizon, 0 100% inducibility their...
Abstract Aims There is currently no gold standard in evaluating frailty patients with heart failure (HF), and the prognostic value of according to Canadian Study Health Aging Clinical Frailty Scale (CFS) on mortality HF still unknown. Methods results Among consecutive 596 after their discharge from Kokura Memorial Hospital (Kitakyushu, Japan) during 2015, at was assessed CFS. Patients were classified into three groups: low ( N = 232, 38.9%), intermediate 230, 38.6%), high 134, 22.5%). The...
Immunogenicity is a key factor capable of influencing the efficacy and safety therapeutic antibodies. A recently developed method called MHC-associated peptide proteomics (MAPPs) uses liquid chromatography/mass spectrometry to identify sequences derived from protein that are presented by major histocompatibility complex class II (MHC II) on antigen-presenting cells, therefore may induce immunogenicity. In this study, we MAPPs technique (called Ab-MAPPs) has high throughput can efficiently...
Although recent studies indicate a high prevalence (12-92%) of TT virus (TTV) DNA in sera healthy Japanese individuals, there is paucity information regarding the route transmission this virus. Analyzing nucleotide sequences existing polymerase chain reaction (PCR) primers TTV DNA, we developed set noble (HM-1) and looked for from 39 normal individuals using PCR. The existence was also checked saliva, urine, sweat, stool, tears 11 semen 10 serum TTV-positive subjects. detected 23 (59.0%) all...
The in vitro micronucleus (MN) test is an important component of a genotoxicity battery that evaluates chemicals. Although the standard method manually scoring micronucleated (MNed) cells by microscope reliable and method, it laborious time-consuming. A high-throughput assay system for detecting MN automatically has long been desired fields pharmaceutical development or environmental risk monitoring. per se cannot clarify whether mode induction aneugenic clastogenic, this clarification may...
Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb include artificial modification amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA). If the new candidate can be understood in nonclinical phase, clinical studies will safer and success rate development improved. Empirically, vitro assays with cells have proved sufficiently sensitive nonhuman proteins, but not human/humanized mAb. To...
Background Although transcatheter aortic valve replacement ( TAVR ) is the least invasive treatment for patients with symptomatic stenosis, some hesitate to undergo procedure. We investigated clinical impact of delay after patient refusal . Methods and Results used Japanese OCEAN (Optimized Catheter valvular intervention) regsitry data 1542 who underwent Refusal was defined as at 1 time informed consent. Patients were separated into 2 groups: (28/1542, 1.8%) non-refusal (1514/1542, 98.2%)....
Therapeutic antibodies sometimes elicit anti-drug (ADAs) that can affect efficacy and safety. Engineered contain artificial amino acid sequences are potentially highly immunogenic, but this is currently difficult to predict. Therefore, it important efficiently assess immunogenicity during the development of complex antibody-based formats. Here, we present an in vitro peripheral blood mononuclear cell-based assay be used potential within 3 days. This method involves examining frequency...
Background: Recent randomized clinical trials have reported favorable outcomes after the use of drug-eluting stents (DES) in patients with acute coronary syndrome (ACS). However, long-term efficacy and safety outcomes, bleeding outcome particular, DES implantation ACS not been thoroughly evaluated a real-world population. Methods Results: We 565 consecutive who underwent an emergency setting between 2004 2011 (ST-segment elevation myocardial infarction [STEMI]: n=269, non-STEMI/unstable...
Pefcalcitol, an analog of vitamin D3 (VD3), is anti-psoriatic drug candidate that designed to achieve much higher pharmacological effects, such as keratinocyte differentiation, than those VD3, with fewer side effects. Genotoxicity the compound was evaluated in a rat skin micronucleus (MN) test. In MN test, pefcalcitol showed positive when specimens were stained Giemsa, whereas neither vitro chromosome aberration test CHL cells nor vivo bone marrow rats indicated clastogenicity. To elucidate...
Background Multifunction cardiogram (MCG) is a computer‐enhanced, resting electrocardiogram analysis developed to detect hemodynamically relevant coronary artery disease (CAD). Based on data from previous studies suggesting excellent diagnostic accuracy in detecting CAD, MCG (approved by the Food and Drugs Administration) received Current Procedure Terminology (CPT) code 2010 United States. However, there no study validating using fractional flow reserve (FFR) as reference standard. Methods...
It is known that continuous stimulation with LHRH induces a biphasic release of LH. The two pools theory generally accepted in interpreting this phenomenon. present study was conducted order to elicit qualitative differences LH included the pools.Five hundred μg synthetic infused for 2h 10 women various phases menstrual cycle and 5h blood sampling performed during after infusion. Biphasic demonstrated all cases investigated. responsiveness most predominant midcycle, followed by luteal phase....
In order to improve the sensitivity and reliability of in vitro bioassay for human luteinizing hormone, various strains male mice at chronological ages were sacrificed obtain dispersed testes interstitial cell preparations. They consisted DDN, DDY, DBA, C57, C3H, ICR, BAL/C 5, 7 9 weeks age. The C57 Black strain, especially age, gave most satisfactory standard dilution curve with a less than 12.5μIU/tube, wide assayable range parallelism sample curve. Improvement assay is expected use strain...
Aortic complex rupture is one of the most critical complications associated with transcatheter aortic valve implantation (TAVI). Its incidence rare, and its mechanism varies by case; therefore, it difficult to identify predictors rupture. Herein, we report a clinical case series Within our cohort, frequency was 0.8% (4/497 consecutive patients) an in-hospital mortality 0. Among these four patients rupture, two underwent emergent thoracotomy surgical hemostasis without heart-lung machine...
Biological and immunological measurements of human luteinizing hormone (hLH) were performed with plasma samples obtained by continuous withdrawal over a 10-hour period in various phases the normal menstrual cycle.A pulsatile pattern hLH discharge was demonstrated both vitro bioassay radioimmunoassay throughout cycle, although frequency amplitude pulse differed according to stage. The decreased half disappearance time immunoreactive (83.7 min 95% confidence limits at 64.3 103.1 min),...
Abstract Acute coronary syndrome (ACS) includes myocardial infarction (MI) and unstable angina (UA). MI is defined by elevated necrosis markers, preferably high-sensitivity cardiac troponins (hs-cTn). However, it takes hours for cTn to become after occlusion; therefore, difficulties are associated with diagnosing early post-onset or UA. The aim of this prospective cohort study was examine the diagnostic ability serum nardilysin (NRDC) detection ACS. This consisted two sequential cohorts,...
Background: We recently reported that the self-care management system for heart failure (HF) decreased re-hospitalization HF. In present study we estimate cost-effectiveness of this system.