A5086065487- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Anomalies
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Voice and Speech Disorders
- Nasal Surgery and Airway Studies
- Facial Nerve Paralysis Treatment and Research
- Tracheal and airway disorders
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Airway Management and Intubation Techniques
- Radiopharmaceutical Chemistry and Applications
- Reconstructive Surgery and Microvascular Techniques
- Urologic and reproductive health conditions
- Vestibular and auditory disorders
- Oral and Maxillofacial Pathology
- Sympathectomy and Hyperhidrosis Treatments
- Obstructive Sleep Apnea Research
- Reconstructive Facial Surgery Techniques
- Hedgehog Signaling Pathway Studies
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Oral Health Pathology and Treatment
Korea Institute of Radiological and Medical Sciences
2013-2025
Kyung Hee University
2023
Chung-Ang University
2020
Seoul National University Bundang Hospital
2010-2013
Seoul National University
2009-2011
Inje University
2008-2009
Seoul National University Hospital
2008
National University College
2008
New Generation University College
2008
Sejong General Hospital
1997-1998
Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to develop clinical practice guidelines for the surgical treatment laryngeal cancer. This conducted systematic search EMBASE, MEDLINE, Cochrane Library, KoreaMed databases identify relevant articles, using terms selected according key questions. Evidence-based recommendations were then created on basis these articles. An external expert review Delphi questionnaire applied reach consensus regarding recommendations. The...
Salivary function in mammals may be defective for various reasons, such as aging, Sjogren's syndrome or radiation therapy head and neck cancer patients. Recently, tissue-specific stem cell has attracted public attention a next-generation therapeutic reagent. In the present study, we isolated cells from human submandibular salivary gland (hSGSCs). To efficiently isolate amplify hSGSCs large amounts, developed culture system (lasting 4–5 weeks) without any selection. After five passages,...
Background: The association of hearing loss with obstructive sleep apnea (OSA) has been investigated in several studies, but analyses using large national population-based datasets are lacking. Therefore, we aimed to determine the effect severity OSA on data from Korea National Health and Nutrition Examination Survey (KNHANES). Methods: We reviewed KNHANES 2019 2021, analyzing 7730 subjects aged 40 older who completed health survey (STOP-BANG questionnaire, SBQ) assessment. According their...
Recently, various endoscopic thyroidectomy techniques have been introduced for cosmetic purposes. However, few reports compared the quality of life (QOL) between post-endoscopic and post-conventional open thyroidectomy. In this study, we investigated whether was comparable to conventional with respect QOL.Between January 2010 September 2011, 75 patients underwent thyroid lobectomy 233 lobectomy. The QOL assessed preoperatively at 1, 3, 6 months postoperatively by using European Organization...
Objective: To analyze clinical manifestations and prognosis of bilateral simultaneous facial nerve palsy (BS-FNP). Study Design: Retrospective case review with current follow-up wherever possible. Setting: Tertiary referral centers. Patients: Patients (n = 7; 4 women 3 men; mean age, 37 yr; range, 18-58 yr) diagnosed BS-FNP at the time their first visit. Intervention: Therapy systemic corticosteroids antiviral agents outpatient for 1 month to years after discharge. Main Outcome Measure:...
Sunitinib, a multi-targeted tyrosine kinase inhibitor, is frequently incorporated into the management of papillary thyroid carcinoma refractory to standard therapies. Although clinical trials are in progress, mechanism action carcinomas not clear, especially regarding effect on BRAF mutation. We investigated sunitinib cells harboring RET/PTC rearrangement and mutation using TPC-1M, SNU-790, B-cPAP cell lines. Cell growth cancer with was effectively inhibited at low doses (IC50=0.658 μM),...
To describe our tracheostomy procedure using a vertical skin incision and horizontal intercartilaginous to compare postoperative results with those in the recent literature.Retrospective chart review literature review.One hundred eleven children underwent over 9-year period. A retrospective was undertaken respect following variables: demographics, weight, primary diagnosis, surgical indication, follow-up duration, decannulation, interval between complications experienced. In addition,...
It is important to properly identify aggressive tumors among differentiated thyroid cancers that are most often indolent. By comparison of a tumorigenic clone with an originally less papillary carcinoma (PTC) cell line, we looked for markers involved in the biology cancer. Human PTC lines BHP10-3 and its subclone BHP10-3SC(mice) were compared using microarray analysis. Upregulated genes selected RT-PCR, immunoblot analysis immunohistochemistry human tissue. Hypoxia-inducible factor (HIF)-1α...
Abstract Background Invasiveness of endoscopic thyroidectomy has been in debate. The purpose this study was to introduce new via a unilateral axillo‐breast approach (UABA) with gas insufflation lessen invasiveness. Methods We performed 68 cases hemithyroidectomy UABA from January July 2011. following variables were studied: operation time, pain score, drainage amount, day, perioperative complications, pathological outcomes, and cosmetic satisfaction. Results Mean postoperative visual...
The epidermal growth factor receptor (EGFR) is one of the most comprehensively studied molecular targets in head and neck squamous cell carcinoma (HNSCC). However, inherent acquired resistance are serious problems responsible for limited clinical efficacy tumor recurrence. In this study, we evaluated feasibility immuno-positron emission tomography (PET) imaging radioimmunotherapy (RIT) with 64Cu-/177Lu-PCTA-cetuximab cetuximab-resistant SNU-1066 HNSCC xenografted model. cellular uptake...
Voice change is a common complaint after thyroid surgery and has significant impact on quality of life. The Korean Society Laryngology, Phoniatrics Logopedics assembled task force to establish guideline recommendations education, care, management related surgery. encompass preoperative voice anticipated during surgery, comprehensive care include in-depth information up-to-date knowledge based validated literature. committee constructed 14 key questions (KQs) in three categories-preoperative...
Gasless transaxillary approach (TA) and the bilateral axillo-breast (BABA) are 2 distinctive approaches for endoscopic thyroidectomy. The purpose of this study was to evaluate compare these procedures.From May 2008 July 2011, we performed hemithyroidectomy via gasless TA (83 cases) BABA (45 cases). following variables were evaluated: operation time, postoperative pain score, drainage amount, day, complications, cosmetic satisfaction score.There no significant differences between in terms...
The Notch signalling pathway is involved in normal development as well tumorigenesis. However, it unclear whether activation related to diverse clinicopathological factors papillary thyroid carcinoma (PTC).We examined the relationship between and expression of activated Notch1 Hey1, which are indicators activation, 109 PTC cases. Activated showed strong, moderate weak 23, 48 36 cases, respectively. Its was significantly histopathological variants (P = 0.007), lymph node metastasis 0.016),...
This study aimed to present our experiences with various approaches for endoscopic thyroidectomy (ET) and offer lessons choosing an approach.The medical records of 701 patients who underwent ET via the transaxillary (TA), bilateral axillo-breast (BABA), unilateral carbon dioxide insufflation (UABA), retroauricular (RA), or transoral vestibular (TO) approach between May 2008 March 2020 were retrospectively reviewed. Postoperative pain cosmetic outcomes evaluated using visual analog scales.The...
Perineural invasion and expression of CXCR4 is characteristic adenoid cystic carcinoma (ACC). Herein, we aimed to demonstrate in ACC, identify its association with perineural investigate the impact inhibitor vitro a murine model.Expression was assessed ACC cell lines human tissue. The effects gene knockdown using siRNA specific blocker (AMD3100) were evaluated vitro. A preclinical model developed BALB/c nude mouse. effect AMD3100 vivo.CXCR4 highly expressed aggressive strains vitro, tumour...
Objectives. Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the locoregional advanced stage (stage IVa), but controversy remains regarding whether IVa HSNCs should be treated with upfront surgery or definitive chemoradiation therapy (CRT). The purpose of this study was to compare overall survival (OS) disease-free (DFS) in patients HNSC primarily by curative intent with/without (neo)adjuvant treatment (surgery group) versus those CRT (CRT group).Methods. We...
ERCC 1 seems to be promising as a predictive marker for response neoadjuvant chemotherapy (NAC) and early decision surgery in advanced squamous cell carcinoma (SCC) of the maxillary sinus.This study aimed find possible relation ERCC1 or XRCC1 expression with NAC prognosis SCC sinus.From 1998 2006, 17 patients sinus received at Seoul National University Hospital. The was assessed by immunohistochemistry. Complete partial remissions were categorized chemo-sensitive group. On other hand, stable...
Poloxamer 407 (POL) is widely used as a thermosensitive hydrogel for intravesical instillation. When POL instilled in the bladder, several problems, including urinary tract obstruction, are observed. To overcome this problem, POL‐based floating (PFH) system was developed. Sodium bicarbonate (BC) agent. PFH optimized using central composite design with two independent variables (X 1 [POL concentration, 42.43%] and X 2 [BC 5.23%]) three response factors (Y [floating time, 240.33 s], Y...
Objectives Although it is well recognized that a small meatus after canal wall down (CWD) tympanomastoidectomy can cause lifetime problem, unsatisfactory results are frequently encountered. We herein introduce novel technique, perichondrial posterior fixation (PPF), to maintain wide external auditory (EAC), minimize postoperative wound infection due the smaller dead space and improve auricular cosmetic outcome. Methods A total of 73 patients who underwent CWD were included. Interventions...
Satellite cells attached to skeletal muscle fibers play a crucial role in regeneration. During regeneration, the satellite proliferate, migrate damaged region, and fuse each other. Although it is important determine cellular mechanisms controlling myoblast behavior, their regulators are not well understood. In this study, we evaluated roles of Fbxw7 primary myoblasts determined its potential as therapeutic target for disease. We originally found that Fbxw7β, one E3 ubiquitin ligase subtypes,...
Papillary thyroid carcinoma (PTC) is known as the most common type of cancer and shows an excellent prognosis with overall 10-year survival rate >90%. With development radiological imaging, especially ultrasonography, incidence has been increasing, diagnosis papillary microcarcinoma (primary tumor ≤1.0 cm) shown highest increase. Due to increased small cancer, extent Head Neck Korean J Otorhinolaryngol-Head Surg 2015;58(11):769-75 / pISSN 2092-5859 eISSN 2092-6529