A5103152862- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Cancer survivorship and care
- Uterine Myomas and Treatments
- Eosinophilic Esophagitis
- Gestational Trophoblastic Disease Studies
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Sarcoma Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Esophageal Cancer Research and Treatment
- Delphi Technique in Research
- Cancer Genomics and Diagnostics
- Gastrointestinal motility and disorders
- Xenotransplantation and immune response
- Enhanced Recovery After Surgery
- Music Therapy and Health
- Testicular diseases and treatments
- Advances in Oncology and Radiotherapy
University of Toronto
2016-2025
Sinai Health System
2024-2025
University Health Network
2021-2025
Princess Margaret Cancer Centre
2016-2025
Check Point (Israel)
2023
Health Net
2021
Gynecologic Oncology Group
2021
Vanderbilt University
2019
Royal Adelaide Hospital
1997
Transplantation of pig tissues into humans has the potential for cotransferring infections. Knowledge epidemiology infections transmissible to allows development risk limitation strategies at source herd level, but potentially infectious endogenous retrovirus (PERV) is ubiquitous in all domestic pigs and therefore not avoidable. Using a specific sensitive RT-PCR nested PCR PERV nucleic acids with primers, screening from New Zealand herds presence expression was conducted. The proviral DNA...
Introduction Sentinel lymph node dissection is widely used in the staging of endometrial cancer. Variation surgical techniques potentially impacts diagnostic accuracy and oncologic outcomes, poses barriers to comparison outcomes across institutions or clinical trial sites. Standardization technique quality assessment tools are critical conduct trials. By identifying mandatory prohibited steps sentinel (SLN) cancer, purpose this study was develop validate a competency tool for use assurance....
Most fear of cancer recurrence (FCR) interventions have small effects, and few target FCR. This randomized controlled trial (RCT) with breast gynecological survivors evaluated the efficacy a cognitive-existential therapy (FORT) compared to an attention placebo control group (living well [LWWC]) on FCR.One hundred sixty-four women clinical levels FCR distress were randomly assigned 6-weekly, 120 min FORT (n = 80) or LWWC 84) sessions. They completed questionnaires at baseline (T1),...
Objectives: To determine the feasibility of implementing Ovarian-Adnexal Reporting & Data System (O-RADS) ultrasound (US) for reporting adnexal masses at our institution, with a specific goal increasing use O-RADS from baseline <5% to least 75% over 16-month period. Methods: A prospective interrupted time series quality improvement study was undertaken Plan, do, study, act cycles included: (1) Engagement interested parties, (2) Targeted educational sessions, (3) Development templates,...
Background: Human papillomavirus (HPV) DNA is detectable in the peripheral blood plasma from patients with locally advanced and metastatic cervical cancer. Levels of HPV circulating tumor (ctDNA) pretreatment have weak associations prognosis, but significance detecting integration into host genome or fragmentation features within ctDNA has not been explored. We hypothesized that these molecular may serve as prognostic biomarkers reflect biology, independent total abundance. Methods: Plasma...
Importance Enhanced Recovery After Surgery (ERAS) guidelines and the World Health Organization Surgical Safety Checklist (SSC) are 2 well-established tools for optimizing patient outcomes perioperatively. Objective To integrate to facilitate key perioperative decision-making. Evidence Review Snowball sampling recruited international ERAS users from multiple clinical specialties. A 3-round modified Delphi consensus model was used evaluate 27 colorectal or gynecologic oncology recommendations...
Growing teratoma syndrome (GTS) after adjuvant chemotherapy for ovarian germ cell tumors is uncommon, with approximately 60 cases reported in the English literature. The objective of this study was to report clinical parameters including outcomes patients a diagnosis GTS immature (IT).Patients condition diagnosed as IT between 1999 and 2014 at 2 tertiary-care academic centers were evaluated development GTS. Patients' demographics, surgical pathology data, treatment, tumor markers, survival...
Introduction As sentinel lymph node biopsy is evolving to an accepted standard of care, clinicians are being faced with more frequent cases small volume nodal metastatic disease. The objective this study describe the management and measure effect on recurrence rates micrometastasis isolated tumor cells in patients early stage cervical cancer at two high-volume centers. Methods We conducted a review prospectively collected surgically treated who were found have or ultrastaging node. Our...
Endometrial cancers classified as "intermediate risk" based on clinical and/or pathologic features are associated with a 15% to 20% risk of recurrence. Here, we test whether global gene expression profiling can distinguish intermediate-risk tumors into high-risk and low-risk subgroups.Tumor specimens were obtained from 75 endometrial cancer patients, 13 who had recurred 62 not median follow-up 24 months. Gene profiles using the Affymetrix U133A GeneChip oligonucleotide microarray. The genes...
We studied 13 patients before and after Nissen fundoplication compared them with 11 healthy volunteers 12 other dysphagia fundoplication. Esophageal manometry was performed to assess primary secondary peristalsis induced by esophageal distention air water boluses. In reflux disease, initiated at a median rate of 60% distending episodes, propagation the peristaltic wave occurred in 40% lower oesophageal sphincter relaxation 70% waves. Fundoplication did not alter initiation or but it...
5044 Background: There is evidence that treatment of gynecologic cancer (GC) negatively affects body image and sexuality. The Sexual Adjustment Body Image Scale in women with GC (SABIS-G) was developed to assess disturbances after GC. Exploratory factor analysis resulted a two structure the underlying constructs sexual adjustment. Our objective confirm using confirmatory (CFA). Methods: Women history without active disease completed SABIS-G, 9-item self-report measure. CFA performed which...