A5101917343- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Oral microbiology and periodontitis research
- Enzyme Structure and Function
- Trace Elements in Health
- Viral Infections and Immunology Research
- Biopolymer Synthesis and Applications
- Otolaryngology and Infectious Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Machine Learning in Healthcare
- Fatty Acid Research and Health
- Probiotics and Fermented Foods
- Cholesterol and Lipid Metabolism
- Bone health and treatments
- Electronic Health Records Systems
- Genetic Syndromes and Imprinting
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
- AI in cancer detection
- Thyroid Cancer Diagnosis and Treatment
Jilin Academy of Agricultural Sciences
2022-2024
McGill University Health Centre
2020-2022
Soochow University
2022
Jinan University
2018-2021
Harbin Medical University
2021
Fourth Affiliated Hospital of Harbin Medical University
2021
BOE Technology Group (China)
2020
Chinese General Hospital College of Nursing and Liberal Arts
2020
Chinese PLA General Hospital
2020
Carnegie Mellon University
2017
Background: This study attempts to determine the antimicrobial resistance profiles of obligate anaerobic bacteria that were isolated from a periodontal abscess and evaluate prevalence genes in these bacteria. Methods: Forty‐one samples cultivated on selective non‐selective culture media isolate oral anaerobes. Their antibiotic susceptibilities clindamycin, doxycycline, amoxicillin, imipenem, cefradine, cefixime, roxithromycin, metronidazole determined using agar dilution method, polymerase...
Streptococcus pneumoniae (pneumococcus) is a leading cause of death and disease in children elderly. Genetic variability among isolates from this species high. These differences, often the product gene loss or acquisition via horizontal transfer, can endow strains with new molecular pathways, diverse phenotypes, ecological advantages. PMEN1 widespread multidrug-resistant pneumococcal lineage. Using comparative genomics we have determined that regulator-peptide signal transduction system,...
Streptococcus pneumoniae, a Gram-positive human pathogen, has evolved three main transporters for iron acquisition from the host: PiaABC, PiuABC, and PitABC. Our previous study had shown that mRNA protein levels of SPD_1590 are significantly upregulated in ΔpiuA/ΔpiaA/ΔpitA triple mutant, suggesting might be novel transporter S. pneumoniae. In present study, using spd1590-knockout, -complemented, -overexpressing strains purified protein, we show can bind hemin, probably supplementing...
Changes in the gene content of pathogens can modify their ability to colonize and/or survive different body sites human host. In this study, we investigate a acquisition event and its role pathogenesis Streptococccus pneumoniae (pneumococcus). Our findings suggest that encoding predicted surface protein SspB has been transferred from Streptococcus suis (a distantly related streptococcal species) into distinct set pneumococcal strains. This group strains distinguishes itself remainder by...
Background Members of the genera Prevotella, Veillonella and Fusobacterium are predominant culturable obligate anaerobic bacteria isolated from periodontal abscesses. When determining cumulative number clinical isolates abscesses, ambiguous or overlapping signals were frequently encountered in 16S rRNA gene sequencing chromatograms, resulting identifications. With exception genus Veillonella, high intra-chromosomal heterogeneity rrs genes has not been reported. Methods The 138 clinical,...
The unreasonable misuse of antibiotics has led to the emergence large-scale drug-resistant bacteria, seriously threatening human health. Compared with drug-sensitive resistant bacteria are difficult clear by host immunity. To fully explore adaptive mechanism iron-restricted environment, we performed data-independent acquisition-based quantitative proteomics on ciprofloxacin (CIP)-resistant (CIP-R) Staphylococcus aureus in presence or absence iron. On bioinformatics analysis, CIP-R showed...
Abstract Aim This study aimed to investigate the positive effect of natto powder on obese rats fed with a high-fat diet (HFD). Methods and results Sprague–Dawley were HFD for 8 weeks continuously gavaged powder, respectively, starting from ninth week. The showed that significantly reduced body weight maintained balance cholesterol metabolism in by inhibiting activity liver X receptors (LXR) target genes, increasing active expression 7 alpha-hydroxylase, reducing sterol-regulatory...
Macromolecular protein crystallisation was one of the potential tools to accelerate biomanufacturing biopharmaceuticals. In this work, it first time investigate roles biotemplates, Saccharomyces cerevisiae live cells, in processes lysozyme, with different concentrations from 20 2.5 mg/mL lysozyme and 0 5.0 × 107 (cfu/mL) during a period 96 h. During period, nucleation possibility droplets, crystal numbers, cell growth density were observed analysed. The results indicated strong interaction...
Electronic Health Record (EHR) contains patient-centric, electronically maintained information about individuals health information. Data Visualization that integrates with EHR is helpful for clinicians and patients to gain better insight into clinical care management. This paper focuses on building EHR, it two aspects: 1. 3D deformable human body model applied as the data visualization method, available constructing customized digital model. The surface, organs, muscle skeleton, changeable...
Background Paget's disease of bone (PDB) is a rare metabolic in China and characterized by increased resorption disorganized formation. The main clinical symptoms PDB are focal or multiple pain deformity with high disability. has missed diagnosis misdiagnosis rates. This report summarizes the manifestations, imaging pathological features, treatments 11 patients at our hospital from 1993 to 2020 order improve recognition prognosis PDB. Case summary There were eight male three female whose...
Glucagon-likepeptide-1(GLP-1)isanimportantincretinhormonethatsecretedfromintestinalLcells.NumerousstudieshaveproventhatGLP-1increases 茁-cellmassthroughpromoting 茁-cellproliferationand
Abstract BackgroundThe association between one-hour plasma glucose (1h-PG) and the incidence of type 2 diabetes has been investigated in previous studies. However, predictive value 1h-PG for risk cardiovascular disease (CVD) all-cause mortality, especially older Asians, only a few Therefore, influence on CVD mortality was evaluated present study. MethodsThe participants were recruited from Chinese People’s Liberation Army General Hospital, categorized into tertiles. The primary outcomes...