A5102001486- Head and Neck Cancer Studies
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Health disparities and outcomes
- Pancreatic and Hepatic Oncology Research
- Sympathectomy and Hyperhidrosis Treatments
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Anesthesia and Pain Management
- Head and Neck Surgical Oncology
- Fungal Infections and Studies
- Pain Management and Opioid Use
- Chronic Myeloid Leukemia Treatments
- Colorectal Cancer Treatments and Studies
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Brain Metastases and Treatment
- Soft tissue tumor case studies
- Blood disorders and treatments
- Moyamoya disease diagnosis and treatment
- Inflammatory Biomarkers in Disease Prognosis
Pusan National University Hospital
2009-2024
Biomedical Research Institute
2019
Pusan National University
2014-2019
Seoul St. Mary's Hospital
2015
Catholic University of Korea
2015
Chungbuk National University
2010
Inje University
2006
Background A wide range of specificity values for the differentiation benign and malignant soft‐tissue tumors show limitations conventional MRI features. The data obtained by quantitative analysis diffusion‐weighted image (DWI) dynamic contrast‐enhanced (DCE) MRIs would provide more objective results, especially in terms cellularity perfusion. Purpose To evaluate diagnostic efficacies DWI DCE tumors. Study Type Retrospective. Subjects In all, 136 patients (68 females, 68 males; age 18–86...
A refractory and resistant disease to conventional induction chemotherapy relapsed are considered as the most important adverse prognostic factors for acute myeloid leukemia (AML). Sixty-one patients (median age, 33.6 yr) with or AML were treated FLAG regimen that consisted of fludarabine (30 mg/m(2), days 1-5), cytarabine (2.0 g/m(2), 1-5) granulocyte colony-stimulating factor. Of 29 (47.5%) achieved complete remission (CR). Higher CR rates observed a first second relapse compared primary...
Purpose The aim of this study is to identify the prognostic factors distant metastasis (DM) after induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) for locoregionally advanced head and neck cancer (HNC). Materials Methods A total 321 patients with HNC who underwent IC CRT treated between January 2005 December 2010 were analyzed retrospectively. consisted three courses docetaxel (70 mg/m2) cisplatin (75 every weeks, radiotherapy 66-70 Gy/2 Gy per fraction/5 fractions...
Pegylated granulocyte-colony-stimulating factor (G-CSF) is frequently used to prevent febrile neutropenia (FN) in patients undergoing chemotherapy with a high risk of myelosuppression. This phase II/III study was conducted determine the adequate dose pegteograstim, new formulation pegylated G-CSF, and evaluate efficacy safety pegteograstim compared pegfilgrastim.In II part, 60 breast cancer who were DA (docetaxel doxorubicin) or TAC (docetaxel, doxorubicin, cyclophosphamide) randomly...
Intracranial granulocytic sarcomas are rare tumors, which composed of immature cells. Although it has been well known that these tumors associated with acute myeloblastic leukemia (AML), they have almost always related to bone marrow relapse. However, isolated recurrence sarcoma following complete remission from prior AML is extremely rare, especially in the central nervous system. A 44-year-old male presented mimicking a falx meningioma two years after by allogenic peripheral blood stem...
Abstract There are many preclinical and epidemiological reports suggesting a correlation between 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR) or HMG-CoAR inhibitor (statin) treatment prognosis in breast cancer. This study aimed to investigate the expression of Korean patients with The on tissue microarrays from 191 who underwent resection 2005 2006 Pusan National University Hospital was assessed by immunohistochemistry (IHC). IHC assessment board-certified pathologist included...
Purpose To evaluate the efficacy of hydromorphone-OROS (HM-OROS) in reducing sleep disturbance and relieving cancer pain. Materials Methods One hundred twenty patients with pain (numeric rating scale [NRS] ≥ 4) (NRS were evaluated. The initial HM-OROS dosing was based on previous opioid dose (HM-OROS:oral morphine=1:5). Dose adjustment study drug permitted at investigator's discretion. Pain intensity, number breakthrough episodes, quality Results A total 120 received least one HM-OROS; 74...
We assessed the success rate of empirical antifungal therapy with itraconazole and evaluated risk factors for predicting failure therapy. A multicenter, prospective, observational study was performed in patients hematological malignancies who had neutropenic fever received at 22 centers. total 391 abnormal findings on chest imaging tests (31.0%) or a positive result enzyme immunoassay serum galactomannan (17.6%) showed 56.5% overall rate. Positive before initiation (P=0.026, hazard ratio...
We aimed to explore the prognostic value of metabolic heterogeneity 18F-FDG uptake in chemoradiotherapy-treated pharyngeal cancer patients.This study included 52 consecutive patients with who underwent PET/CT before definitive chemoradiotherapy. The factor (HF) was defined as derivative (dV/dT) a volume-threshold function for primary tumors and metastatic lymph nodes. relationships between clinical parameters HFs (pHF) nodes (nHF) were analyzed.The pHF (range=∓1.367 - -0.027; median=-0.152)...
Yun Hee Kim, Seung Hun Lee, Ho Seop Lim, Young Jin Choi, Sang Yeoup Jeong Gyu Dong Wook Jeong, and Kyoung Hwa Yu. J Hosp Palliat Care 2015;18:314-21. https://doi.org/10.14475/kjhpc.2015.18.4.314
Extended-release osmotic extended-release oral delivery system (OROS) hydromorphone is a strong synthetic opioid designed to maintain constant blood concentration by once daily dosing.The objective of this observational study was investigate the clinical usefulness OROS in patients with cancer pain moderate severe intensity.Patients who required opioids were administered for 4 weeks.We assessed changes intensity using numerical rating scale (NRS) as well levels sleep disturbance,...
Immune checkpoint inhibitors (ICIs) reverse immunoediting and help the host immune system to destroy cancer cells.The increased use of ICIs has led recognition immune-related adverse events (iRAEs) that can affect almost every organ or system.ICI-related myocarditis a rare iRAE tends be severe potentially life-threatening.Herein, we report case patient with malignant melanoma who was treated immunotherapy showed signs both focal segmental glomerulosclerosis myocarditis.The underwent coronary...
Since oxidative stresses are involved in gastroenteritis and diarrhea, we investigated antioxidative antidiarrheal activities of persimmon flesh extract (PFE) calyx (PCE) vitro vivo, respectively. PCE significantly scavenged 1,1-diphenyl-2-picrylhydrazyl hydrate 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) from 500 µg/mL, although PFE was ineffective. In addition, exhibited strong nitric oxide-scavenging effects 1 which superior to ascorbic acid (50 µM). Furthermore, inhibited...
It is widely known that the prognosis of acute myeloid leukemia (AML) depends on chromosomal abnormalities. The majority AML patients relapse and experience a dismal disease course despite initial remission.We reviewed medical records laboratory findings 55 who had relapsed between 2004 2013 been treated at Division Hematology Pusan National University Hospital.The event-free survival (EFS) was related to prognostic karyotype classification time diagnosis (unfavorable vs. favorable or...
This study aimed to evaluate the potential of metabolic activity psoas muscle measured by 18F-fluorodeoxyglucose positron emission tomography-computed tomography predict treatment outcomes in patients with resectable breast cancer.The medical records 288 who had undergone surgical resection for stages I-III invasive ductal carcinoma between January 2014 and December Pusan National University Hospital were reviewed. The standardized uptake values (SUVs) bilateral normalized using mean SUV...
Priming with granulocyte macrophage colony-stimulating factor (GM-CSF) plus all-trans retinoic acid (ATRA) during induction chemotherapy may enhance response rates and survival in patients acute myeloid leukemia (AML) due to the differentiation of human myeloblastic cells into granulocytes.GM-CSF was administered ATRA ingested orally on days 1 14. Patients undergoing a regimen GM-CSF were evaluated as compared historical control group subjects.For enrolled this study, complete remission...
Acquired hemophilia is a rare but potentially life-threatening hemorrhagic disorder caused by the development of autoantibodies against coagulation factor VIII. Concentrates human VIII, desmopressin, activated prothrombin complex concentrates, recombinant VII can all be used to control episodes acute bleeding. The recent availability bypassing agents like has been shown clinically safe and effective as treatment for In this case report, 67 year-old male patient with Rh negative blood type...
Secondary upper extremity lymphedema after lymph node dissection in breast cancer patients is a major complication affecting their quality of life. As lymphatic function compromised before symptoms develop most cases, early diagnosis and intervention symptomatic manifestation known to prevent severe progression lymphedema. In this case report, we present patient with secondary lymphedema, whose disease could be diagnosed at an stage using indocyanine green (ICG) lymphography. The had mild...