A5047566541- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Protein Structure and Dynamics
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Enzyme Production and Characterization
- Ginkgo biloba and Cashew Applications
- Microbial Metabolic Engineering and Bioproduction
- Supramolecular Self-Assembly in Materials
- Blood properties and coagulation
- Polysaccharides Composition and Applications
- Adenosine and Purinergic Signaling
- Catalysis for Biomass Conversion
- Plant biochemistry and biosynthesis
- Molecular Sensors and Ion Detection
- Protein Kinase Regulation and GTPase Signaling
- Rheology and Fluid Dynamics Studies
- Pharmacogenetics and Drug Metabolism
- Photopolymerization techniques and applications
- Phytochemistry and Biological Activities
- Neuroscience and Neuropharmacology Research
- Enzyme-mediated dye degradation
Kyushu University
2024
Tianjin University of Science and Technology
2018-2023
State Key Laboratory of Food Nutrition and Safety
2021
The fibrillogenesis of amyloid-β protein (Aβ) is considered a crucial factor in the pathogenesis Alzheimer's disease (AD). Hence, inhibiting Aβ regarded as primary therapeutic strategy for prevention and treatment AD. However, development effective inhibitors against has faced significant challenges. Previous studies have shown that pristine single-walled carbon nanotubes (SWNTs) can inhibit some amyloid proteins. poor dispersibility SWNTs an aqueous environment greatly hinders their...
Misfolding and fibrillogenesis of amyloid-β protein (Aβ) play a key role in the onset progression Alzheimer's disease (AD). Screening for inhibitors against Aβ amyloidogenesis is helpful rational designing developing new anti-AD drugs therapeutic strategies. Dihydromyricetin, natural flavonoid extracted from Chinese herb, Ampelopsis grossedentata, has been proven with antioxidative, anti-inflammatory, neuroprotective effects neurodegenerative disease. Herein, we found that dihydromyricetin...
Fibrillogenesis of α-synuclein (αSN) is associated with the onset and progression Parkinson's disease (PD). Dihydromyricetin (DHM), a natural flavonoid compound extracted from Ampelopsis grossedentata, has proven antioxidative, antineuroinflammatory, neuroprotective effects in dementia. However, it remains unclear if DHM can impede αSN fibrillogenesis attenuate corresponding cytotoxicity. Herein, we found that could inhibit destabilize mature fibrils dose-dependent manner. Moreover,...
Amyloid self-assembly is pathologically linked to many neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's (PD). While inhibitors have been developed individually for specific amyloid proteins, there are a few effective platforms screen on large scale general against different proteins. Herein, we new class of inhibitor probes by site-specific conjugation aggregation-induced emission (AIE) molecules with proteins (i.e., AIE@amyloid probes) realize high-throughput...
β-Amyloid (Aβ) is regarded as an important pathogenic target for Alzheimer’s disease (AD), the most prevalent neurodegenerative disease. Aβ can assemble into oligomers and fibrils, produce neurotoxicity. Therefore, aggregation inhibitors may have anti-AD therapeutic efficacies. It was found, here, that marine-derived alkaloid, fascaplysin, inhibits fibrillization in vitro. Moreover, new analogue, 9-methylfascaplysin, designed synthesized from 5-methyltryptamine. Interestingly,...
The inhibitory effect of brazilin against α-synuclein (α-syn) fibrillogenesis, disruption mature fibrils, and the following cytotoxicity were examined by systematical biochemical, biophysical, cellular biological, molecular simulation experiments. It is found that inhibited α-syn fibrillogenesis disrupted performed fibrils with a concentration-dependent manner. Moreover, experimental data showed effectively reduced induced aggregates. Finally, dynamics simulations to explore interactions...
Cyanidin-3-<italic>O</italic>-glucoside, a common anthocyanin, is potential functional inhibitor to ameliorate Alzheimer's disease by inhibiting Aβ fibrillogenesis, disrupting the mature fibrils, and reducing amyloid-induced cytotoxicity.
Previous work has shown that edaravone inhibits fibrillogenesis of amyloid-β protein (Aβ). However, the detailed mechanism by which conformational transition Aβ42 monomer is not known at molecular level. Here, explicit-solvent dynamics (MD) simulations were coupled with mechanics-Poisson-Boltzmann surface area (MM-PBSA) method to address issue. MD confirmed in a dose-dependent manner. It was found direct interactions between and are responsible for its inhibiting effects. The analysis...
A safe food additive, fast green FCF, was identified and characterized to be capable of inhibiting α-synuclein fibrillogenesis, disassembling mature fibrils reducing the related cytotoxicity.
Misfolding and the subsequent self-assembly of amyloid-β protein (Aβ) is very important in occurrence Alzheimer's disease (AD). Thus, inhibition Aβ aggregation currently an effective method to alleviate treat AD. Herein, a carboxylated single-walled carbon nanotube (SWCNT-COOH) was rationally designed based on hydrophobic binding-electrostatic repulsion (HyBER) mechanism. The inhibitory effect SWCNT-COOH fibrillogenesis first studied. Based results thioflavin T fluorescence atomic force...
Aggregation of amyloid β peptide (Aβ) is closely associated with the occurrence and development Alzheimer's disease (AD). Reproducible detailed studies on aggregation kinetics structure various aggregates have been conducted using recombinant Aβ peptides. While His6-tag commonly used in purification proteins due to its great simplicity affinity, there little information His6-tagged corresponding cytotoxicity. Moreover, it also unclear whether an effect amyloidogenicity cytotoxicity Aβ1–42....
We have previously discovered an amine-containing flavonoid monomer FM04 as a potent P-glycoprotein (P-gp) inhibitor (EC50 = 83 nM). Here, series of photoactive analogues were synthesized and used together with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the FM04-binding sites on P-gp. Point mutations around photo-crosslinked made for verification. Together results from mutational studies, molecular docking, dynamics simulations, it was found that can interact Q1193...
Time-dependent density functional theory studies were performed to investigate the photochemistry properties of widely used aliphatic polyamide (APA), alias nylon, under ultraviolet radiation with
Previous studies have indicated that 5-hydroxycyclopenicillone (HCP), an active compound derived from marine sponge, could inhibit oligomerization of amyloid β-protein (Aβ). However, the molecular basis for interaction between HCP and Aβ remains unclear. Herein, all-atom dynamics (MD) simulations were used to explore conformational conversion Aβ40 monomer at different concentrations (0-40 mM) atomic level. It is confirmed transition prevented by in a concentration-dependent manner silico. In...