A5100644690- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- melanin and skin pigmentation
- Renal and related cancers
- Plant Molecular Biology Research
- Thyroid Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Plant and Fungal Species Descriptions
- Seaweed-derived Bioactive Compounds
- Metabolism and Genetic Disorders
- Magnetic and Electromagnetic Effects
- Bacillus and Francisella bacterial research
- Axon Guidance and Neuronal Signaling
- Genetic Mapping and Diversity in Plants and Animals
- Microbial Natural Products and Biosynthesis
- Nuclear Receptors and Signaling
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- Photosynthetic Processes and Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Genetic and Kidney Cyst Diseases
- Sperm and Testicular Function
- Erythrocyte Function and Pathophysiology
First Affiliated Hospital of Zhengzhou University
2019-2024
Peking University Shenzhen Hospital
2021
University of Hong Kong - Shenzhen Hospital
2021
Qinghai University
2021
Qinghai Tibetan Hospital
2021
Sun Yat-sen University
2021
Qinghai University for Nationalities
2020
State Ethnic Affairs Commission
2020
Ningxia Medical University
2020
Ningxia University
2020
Despite the accumulation of data on genetic and molecular understanding heterosis, there is little information regulation heterosis at physiological level. In this study, we performed a quantitative analysis endogenous gibberellin (GA) content expression profiling GA metabolism signaling genes to investigate possible relationship between for seedling development in rice (Oryza sativa). The materials used were an incomplete diallele set 3 × crosses six parents. growing shoots seedlings 20 d...
Significance Anthrax toxin proteins engineered to require activation by tumor-associated proteases show high specificity and potency in suppression of solid tumor growth through actions on endothelial cells. The strongly inhibits proliferation Importantly, an immunosuppressive regimen (pentostatin plus cyclophosphamide) not only prevents induction toxin-neutralizing antibodies, allowing multiple courses treatment, but also has strong synergy with the tumors. ability give repeated doses...
Spermiogenesis is a complex process depending on the sophisticated coordination of myriad testis-enriched gene regulations. The regulatory pathways that coordinate this are not well understood, and we demonstrate here AXDND1, as novel essential for spermiogenesis male fertility. AXDND1 exclusively expressed in round elongating spermatids humans mice. We identified two potentially deleterious mutations unique to non-obstructive azoospermia (NOA) patients through selected exonic sequencing....
Purpose: To investigate the role of Nrf2/HO-1 signaling pathway in angiogenesis and whether dextran sulfate (DS) could suppress by inhibiting gastric cancer.Methods: In vitro; Western blot analyzed expression Nrf2 cell lines.Tube formation assay observed effect gradient concentration DS on angiogenic potential HGC-27 cells.Immunofluorescence,western qPCR effects Nrf2, HO-1 VEGF under hypoxia time.Immunofluorescence,western blot,qPCR tube up-regulating or down-regulating cells.In vivo:...
Eph receptor tyrosine kinases are critical for cell‑cell communication during normal and oncogenic development. A3 (EphA3) expression is associated with tumor promotion in certain types of cancer; however, it acts as a suppressor others. The levels EphA3 its effects on progression esophageal squamous cell carcinoma (ESCC) lines were determined using reverse transcription‑quantitative polymerase chain reaction analysis Transwell invasion assay. present study demonstrated that was decreased...
Hereditary renal cystic diseases are characterized by defects in primary cilia of tubular epithelial cells and abnormality epithelium, which ultimately result the development cysts. However, mechanism leading from epithelium to cystogenesis is not well understood. In this report, we demonstrate a critical role for Robo2 regulating development, including ciliogenesis, polarization, differentiation. We found that deficiency results kidneys, cyst showed defective polarity epithelium. The cells,...
Background Dyschromatosis symmetrica hereditaria (DSH) is a rare autosomal dominant inherited pigmentary dermatosis characterized by mixture of hyperpigmented and hypopigmented freckles on the dorsal aspect distal extremities. To date, pathogenic mutations causing DSH have been identified in adenosine deaminase acting RNA1 gene ( ADAR1 ), which mapped to chromosome 1q21. Objective The present study aimed investigate underlying pathological mechanism 14 patients with from five unrelated...
Cornus bretschneideri L.Henry (Cornaceae), a shrub or small tree, is potential horticultural plant soil-fixing plant. In this study, the complete sequence and characterization of chloroplast genome C. was studied. The size 158,270 bp in length, including large single copy region (LSC) 87,466 bp, (SSC) 18,730 pair inverted repeat (IR) regions with 26,037 bp. GC content 37.86%. Moreover, total 132 functional genes were annotated, 87 protein-coding genes, 37 tRNA 8 rRNA genes. neighbor-joining...
To investigate the clinical and genetic features of a child with Dyschromatosis symmetrica hereditaria (DSH) variant ADAR1 gene.
Cell adhesion molecule 2 (CADM2) is an immunoglobulin (Ig)-like cell molecule, which belongs to the CADMs family. The four members of family including three Ig-like domains and a short cytoplasmic tail share high degree identity with each other, making it difficult specifically identify using western blotting or immunohistochemistry. And most anti-CADM2 antibodies available commercially used in published papers are rabbit polyclonal antibodies, exhibiting nonspecific recognition studies. In...
Reorganization of topologically associated domain (TAD) is considered to be a novel mechanism for cell fate transitions. Here, we present protocol manipulate TAD via abscisic acid (ABA)-dependent genome linking. We use this merge two adjacent TADs and evaluate the influence on The advantages are that manipulation does not change reversible by withdrawing ABA. major challenge how select linking loci efficient reorganization. For complete details execution protocol, please refer Wang et al. (2021).
Mitogen-activated protein kinases (MAPKs) are a class of that regulate various physiological processes, and play crucial role in maintaining osmotic equilibrium fish. The objective this study was to identify characterize the mapk family genes cobia (Rachycentron canadum), examine their expression profiles under different low salinity stress. As result, total 12 (Rcmapks) were identified cloned, including six erk (Rcmapk1/3/4/6/7/15), three jnk (Rcmapk8/9/10) p38 (Rcmapk 11/13/14) subfamily...
To detect mutations of ADAR gene in two pedigrees affected with dyschromatosis symmetrica hereditaria (DSH).Potential the were analyzed by Sanger sequencing probands from both pedigrees. Suspected validated other patients as well unrelated healthy individuals.A heterozygous nonsense mutation c.1325C>G (p.Ser442Ter) and a novel c.1498C>T (p.Gln500Ter) respectively identified among all but not 200 individuals.Mutations probably underlie DSH Above findings have enriched spectrum mutation.
Abstract Dyschromatosis symmetrica hereditaria (DSH) is a rare autosomal dominant inherited pigmentary dermatosis characterized by mixture of hyperpigmented and hypopigmented freckles on the dorsal aspect distal extremities. To date, pathogenic mutations causing DSH have been identified in adenosine deaminase acting RNA1 gene ( ADAR1 ), which mapped to chromosome 1q21. The present study aimed investigate underlying pathological mechanism 14 patients with from five unrelated Chinese families....
Abstract Dyschromatosis symmetrica hereditaria (DSH) is a rare autosomal dominant inherited pigmentary dermatosis characterized by mixture of hyperpigmented and hypopigmented freckles on the dorsal aspect distal extremities. To date, pathogenic mutations causing DSH have been identified in adenosine deaminase acting RNA1 gene ( ADAR1 ), which mapped to chromosome 1q21. The present study aimed investigate underlying pathological mechanism 14 patients with from five unrelated Chinese families....
Fallopia aubertii (L.Henry) Holub (Polygonaceae), a woody plant with voluble stem, is used as folk herbal medicines for the treatment of gout, fever and pneumonia. To better understand molecular genetics F. aubertii, its complete chloroplast genome was sequenced annotated. The assembled circular 160,951 bp sequence consisting large single copy (87,279 bp) small (13,394 regions, separated by two inverted repeat regions (30,860 each). contains 131 genes including 86 protein-coding, 37 tRNA 8...