A5101676485- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Cardiovascular Conditions and Treatments
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Vascular anomalies and interventions
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Congenital heart defects research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Tracheal and airway disorders
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Tissue Engineering and Regenerative Medicine
- Platelet Disorders and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Heart Failure Treatment and Management
- Vascular Anomalies and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Mesenchymal stem cell research
General Hospital of Shenyang Military Region
2015-2025
Mayo Clinic
2022
Shenyang 242 Hospital
2010-2017
China Pharmaceutical University
2015
Northern Hospital
2013
Jinzhou Medical University
2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
Chinese PLA General Hospital
2007
Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate of oral compared placebo time to first adjudicated worsening event participants PAH who recently began approved monotherapy.Methods: In this event-driven, double-blind study, we randomly allocated 690 (1:1 ratio) receive or extended-release tablets three times daily. Eligible were using monotherapy for over 30...
Abstract Background and objective Nationally representative reports on the characteristics long‐term survival of pulmonary arterial hypertension (PAH) from developing countries are scarce. The applicability current main risk stratifications longitudinal changes in goal‐oriented treatments have yet to be elucidated real‐world settings. Therefore, we aimed provide insights into characteristics, PAH China explore our independent cohort. Methods patients were consecutively enrolled a national...
Adipose-derived stem cells (ADSCs) are capable of differentiating into cardiomyogenic and endothelial in vitro. We tested the hypothesis that transplantation ADSCs myocardial scar may regenerate infracted myocardium restore cardiac function.ADSCs were isolated from fatty tissue New Zealand white rabbits cultured Iscoves modified dulbeccos medium. Three weeks after ligation left anterior descending coronary artery rabbits, either a graft untreated (UASCs, n = 14), 5-azacytidine-pretreated...
Abstract Objective: To assess the feasibility of transcatheter closure in patients with dextrocardia and isolated atrial septal defect or ventricular defect. Methods: A retrospective analysis was performed on clinical data 10 from June 2013 to January 2023 successfully underwent closure. Patient were meticulously collected. Results: The study cohort comprised patients, three males, aged between 3 38 years. Intraoperative right heart catheterisation revealed following measurements: mean...
Background The next-generation closure device for interventional treatment of patent foramen ovale (PFO) is regarded as biodegradable, yet the corresponding biomaterial technique still challenging. Herein, we report clinical application a novel biodegradable PFO occluder [made material polydioxanone (PDO)] that finally coming into use. Objectives This study aimed to assess safety and efficacy Pansy® (Mallow Medical, Shanghai, China) in patients exhibiting with substantial right-to-left shunt...
To assess the immediate and long-term outcomes of transcatheter closure ventricular septal defect (VSD) in combination with percutaneous coronary intervention (PCI) patients VSD complicating acute myocardial infarction (AMI).Data were prospectively collected from 35 AMI who underwent attempted PCI therapy five high-volume heart centres. All survived procedures followed up by chest x-ray, electrocardiogram echocardiography. Thirteen urgent phase (within two weeks VSD) while others elective at...
Transcatheter closure of coronary artery fistulae (CAF) has emerged as an alternative to surgery, but there are no long-term outcome results.We report immediate and results in 24 patients after transcatheter congenital CAF.A total aged 5 56 years old with CAF underwent attempted percutaneous using various devices between November 1998 August 2008. The clinical follow-up were reviewed.Of the patients, 20 (83.3%) successful devices. An angiogram right device deployment revealed complete...
No method is available to predict whether patients with patent ductus arteriosus (PDA) and severe pulmonary arterial hypertension (PAH) will show persistent postprocedural PAH (PP-PAH) after PDA closure. This study evaluated the usefulness of trial occlusion for predicting PP-PAH transcatheter closure in PAH.Trial was performed 137 (age ≥12 years) PAH. All undergoing had a mean artery pressure ≥45 mm Hg, pulmonary:systemic flow (Qp/Qs) ratio >1.5, resistance (Rp/Rs) <0.7. A total 135 (98%)...
We investigated the acute vasodilator effects of i.v. fasudil, a specific Rho-kinase inhibitor, on pulmonary circulation in patients with congenital heart defects (CHD) and severe arterial hypertension (PAH).Thirty-five (34.23±12.10 years old) CHD PAH were consecutively enrolled. All underwent catheterization. At baseline 30 min after initiation following hemodynamic parameters measured calculated: right atrial pressure, systemic artery pressure (PAP SAP), vascular resistance,...
AimsCardiac structural genes have been implicated as causative factors for congenital heart diseases (CHDs). NEXN is an F-actin binding protein and previously identified a disease gene causing cardiomyopathies. Whether contributes to CHDs aetiologically remains unknown. Here, we explored the function of in cardiac development.
We retrospectively reported our 26-year experience with operative repair of total anomalous pulmonary venous connection (TAPVC) biventricular physiology.Between December 1982 and 2008, 122 TAPVC patients heart underwent surgical in department. Moderate or deep hypothermia was induced at the time cardiopulmonary bypass (CPB). Follow-up conducted for 5 postoperative years. Surgical outcomes early intermediate deaths after were analyzed.Six occurred operatively; three deaths, during follow-up....
BACKGROUND:Use of renin-angiotensin-aldosterone system inhibitors in coronavirus disease 2019 (COVID-19) patients lacks evidence and is still controversial. This study was designed to investigate effects angiotensin-converting enzyme (ACEIs) or angiotensin II receptor blockers (ARBs) on clinical outcomes COVID-19 assess the safety ACEIs/ARBs medication. MATERIAL AND METHODS:COVID-19 with hypertension from 2 hospitals Wuhan, China, 17 Feb 18 Mar 2020 were retrospectively screened grouped...
It has been demonstrated that sildenafil is effective in patients with pulmonary arterial hypertension (PAH). However, the impact of on PAH adults congenital heart disease (CHD) less investigated.In this prospective, open-label, uncontrolled and multicenter study, 60 related to CHD received oral (75 mg/day) for 12 weeks. The enrolled underwent six-minute walk test (SMWT) cardiac catheterization at beginning end primary point was changes exercise capacity assessed by SMWT; secondary included...
Objective To evaluate the clinical efficacy, safety, and long-term outcomes of percutaneous closure (PC) surgical repair ruptured sinus Valsalva aneurysm (RSVA). Methods Eighty-five consecutive patients with RSVA were included in this study. Patients considered candidates for PC if they met criterion, was performed on who unsuitable or failed PC. Of them, 30 underwent PC, while other 55 had repair. Results successfully occluded 29 treated by The mean narrowest diameter at site 6.45 ± 1.60 mm...
The impact of sildenafil on pulmonary arterial hypertension (PAH) in Chinese patients has been less investigated. A prospective, open‐label, uncontrolled and multicenter study, therefore, was carried out to address this issue. Ninety with multicause‐induced PAH received oral (75 mg/day) for 12 weeks. 6‐minute walk test (SMWT) cardiac catheterization were performed at the beginning end primary endpoint changes exercise capacity assessed by SMWT; secondary included assessment functional class,...
There is no generally accepted comprehensive risk prediction model cooperating factors associated with heart failure and pulmonary hemodynamics for patients hypertension due to left disease (PH-LHD). We aimed explore outcome correlates evaluate incremental prognostic value of in PH-LHD.Consecutive chronic undergoing right catheterization were prospectively enrolled. The primary endpoint was all-cause mortality. Individual variable selection performed by machine learning methods. Cox...
Previous studies have demonstrated cardiac and vascular remodeling induced by microgravity exposure. Yet, as the most important branch of vasculatures circulating heart, coronary artery has been seldomly studied about its adaptations under conditions. Large‐conductance Ca 2+ ‐activated potassium channel (BK ) Ras homolog family member A (RhoA)/Rho kinase (ROCK) pathway play key roles in control tone mediation microgravity‐induced adjustments. Therefore, we investigated adaptation...