A5071644013- Hormonal Regulation and Hypertension
- Temporomandibular Joint Disorders
- Prostate Cancer Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Prostate Cancer Treatment and Research
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Lipoproteins and Cardiovascular Health
- Radiomics and Machine Learning in Medical Imaging
- Botulinum Toxin and Related Neurological Disorders
- Cardiac Arrest and Resuscitation
- Hip and Femur Fractures
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- MRI in cancer diagnosis
- Receptor Mechanisms and Signaling
- Advanced Radiotherapy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Vitamin K Research Studies
- Anesthesia and Neurotoxicity Research
- Lung Cancer Treatments and Mutations
- Adipokines, Inflammation, and Metabolic Diseases
Universidad Europea
2015-2025
Spanish National Centre for Cardiovascular Research
2013-2024
University of Naples Federico II
2024
Instituto Português Da Qualidade
2023-2024
Hospital General Universitario Gregorio Marañón
2019-2024
Universidad Europea
2018-2023
Hospital Universitario Miguel Servet
2023
Hospital Universitario Fundación Jiménez Díaz
2022
Centro de Investigación en Red en Enfermedades Cardiovasculares
2021
Laureate Education
2018
The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces administered early (intravenously before reperfusion).Patients Killip class II or less anterior ST-segment-elevation myocardial infarction (STEMI) undergoing within 6 hours symptoms onset were randomized to receive intravenous (n=131) not (control, n=139) reperfusion. All patients without contraindications received oral 24 hours....
Abstract The β1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. prevailing view has been that acts mainly on cardiomyocytes. Here, we demonstrate reperfusion injury by targeting the haematopoietic compartment. Metoprolol inhibits neutrophil migration an ADRB1-dependent manner. during early phases of recruitment impairing structural and functional rearrangements needed for productive engagement circulating platelets,...
Objectives— Patients with mutations in the proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) gene have hypercholesterolemia and are at high risk of adverse cardiovascular events. We aimed to stably express pathological human D374Y gain-of-function mutant form DY adult wild-type mice generate a hyperlipidemic proatherogenic animal model, achieved single systemic injection adeno-associated virus (AAV). Approach Results— constructed an AAV-based vector support targeted transfer liver....
We investigated the role of angiotensin II in vascular and circulating inflammatory markers spontaneously hypertensive rats (SHR). IL-1beta, IL-6, TNF-alpha aortic mRNA expression plasma levels were measured adult SHR untreated or treated with receptor antagonist candesartan (2 mg.kg(-1).day(-1)) antihypertensive triple therapy (TT; mg.kg(-1).day(-1): 20 hydralazine + 7 type 1 hydrochlorothiazide 0.15 reserpine) for 10 wk. Likewise, NF-kappaB p50 subunit precursor p105 its inhibitor...
Background/Objectives: To analyze the predictive value of apparent diffusion coefficient (ADC) in patients with prostate cancer (PCa) treated radiotherapy (RT) and androgen deprivation therapy (ADT). Methods: Retrospective study high-risk, very or unfavorable intermediate-risk PCa who received RT ADT between 2008 2019 underwent multiparametric magnetic resonance imaging mpMRI) at 6 months post-RT. Differences ADC values were compared without progression and/or local recurrence. Receiver...
To evaluate the impact of smoking on acute and chronic toxicity in early breast cancer patients treated with hypofractionated intensity-modulated radiation therapy (IMRT) a brachytherapy boost following breast-conserving surgery. A retrospective study 638 between 2009 2017, 566 having recorded status. Acute was assessed at treatment end least one-year post-treatment, using Common Terminology Criteria for Adverse Events v4.0. Statistical analyses included chi-square tests relative risk (RR)...
The aim of the present study was to evaluate effect aldosterone receptor antagonist eplerenone on endothelial function, oxidative stress, and structural alterations in spontaneously hypertensive rats (SHR). To carry out study, male SHR (18 weeks old) were treated with two doses (30 100 mg/kg/day) for 10 weeks. A group n = 8 untreated used as a control-vehicle group, Wistar Kyoto (n 8) reference normotensive conditions. Systolic arterial pressure (SAP) measured by tail-cuff method....
Objective To evaluate the effect of low-intensity chronic exercise training (ExT) on blood pressure (BP), as well cardiac alterations associated with hypertension in aging hypertensive rats. Methods Male spontaneously rats (SHR; 21 months old) and their normotensive control Wistar–Kyoto (WKY) were submitted to protocol for 13 weeks. BP, morphological morphometric analysis, gene expression fibrotic inflammatory factors analyzed at end period. Results ExT reduced BP heart rate aged SHR. Left...
Beta-3 adrenergic receptor (β3AR) agonists have been shown to produce vasodilation and prevention of ventricular remodeling in different conditions. Given that these biological functions are critical pulmonary hypertension (PH), we aimed demonstrate a beneficial effect β3AR PH. An experimental study pigs (n = 34) with chronic PH created by vein banding was designed evaluate the acute hemodynamic long-term on hemodynamics, vascular RV performance Ex vivo human experiments were performed...
Several studies have considered Botulinum Neurotoxin Type A injections effective in treating temporomandibular joint disorder (TMD) symptoms. double-blind, randomized, controlled clinical trial investigated the benefit of complementary incobotulinumtoxinA (inco-BoNT/A) masticatory muscles patients submitted to bilateral (TMJ) arthroscopy.Fifteen with TMD and an indication for TMJ arthroscopy were randomized into inco-BoNT/A (Xeomin, 100 U) or placebo groups (saline solution). Injections...
The aim of the present study was to evaluate effect overstimulation beta-adrenoceptors on vascular inflammatory mediators. Wistar rats were treated with beta-adrenoceptor agonist isoproterenol (0.3 mg.kg(-1).day(-1) sc) or vehicle (control) for 7 days. At end treatment, right carotid artery catheterized arterial and left ventricular (LV) hemodynamic evaluation. Isoproterenol treatment increased LV weight but did not change parameters. Aortic mRNA protein expression quantified by real-time...
Although exogenous nitric oxide (NO) clearly modifies platelet function, the role and source of endogenous NO in vivo remain undefined. In addition, endothelial synthase (NOS-3) critically regulates vessel tone but its modulating function is unclear. this paper we have investigated roles NOS-3 regulating determined functional contribution made by platelet-derived NO.We used a mouse model for directly assessing responses situ presence an intact vascular endothelium with supporting vitro...
Abstract N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It used as drug solubilizer and penetration enhancer in human animal, yet its bioactivity properties remain elusive. Here, we report that NMP bioactive anti-inflammatory compound well tolerated vivo, shows efficacy reducing disease mouse model of atherosclerosis. Mechanistically, increases the expression transcription factor Kruppel-like 2 (KLF2) . Monocytes endothelial cells treated with express...
Objective To investigate the participation of aldosterone in vascular inflammatory process associated with hypertension, as well possible involvement NFκB/IκB system. Methods Male spontaneously hypertensive rats (SHR; 20–22 weeks old) untreated or treated either receptor antagonist, eplerenone (100 mg/kg per day) triple antihypertensive therapy (HHR: hydralazine + hydrochlorothiazide reserpine; 20 7 0.15 were used study. Wistar–Kyoto (WKY) a normotensive reference group. Aortic mRNA...
The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular renal damage associated with hypertension.Spontaneously hypertensive rats (SHR) were treated two doses (100 30 mg/kg per day) mineralocorticoid receptor antagonist eplerenone, or antihypertensive therapy (HHR) (20 day hydralazine + 7 hydrochlorothiazide 0.15 reserpine).CTGF mRNA expression protein levels aorta SHR upregulated (P < 0.05)...
Over recent years, temporomandibular joint (TMJ) minimally invasive procedures, such as arthrocentesis and arthroscopy, have been appointed an initial TMJ intra-articular treatment. Both procedures present safe effective clinical results in managing disorders (TMD) by reducing pain improving mouth opening. The use of these techniques adults is validated the literature. However, data on safety effectiveness interventions pediatric patients are scarce. This study aims to investigate...
Background. Numerous studies have shown that elevated plasma cholesterol can exacerbate renal disease. However, the effect of lipids on structure and vascular function in normal kidneys is less well established. Therefore, aim this study was to evaluate impact hypercholesterolaemia glomerular reactivity segmental arteries rabbits. In addition, we also studied whether or not atorvastatin prevent these structural alterations hypercholesterolaemic
The study investigated whether the amelioration of endothelial dysfunction by candesartan (2 mg·kg -1 ·day ; 10 wk) in spontaneously hypertensive rats (SHR) was associated with modification hepatic redox system. Systolic arterial pressure (SAP) higher ( P < 0.05) SHR than Wistar-Kyoto (WKY) and reduced both strains. Acetylcholine (ACh) relaxations were smaller contractions induced ACh + N G -nitro-l-arginine methyl ester (l-NAME) greater WKY. Treatment enhanced l-NAME Expression aortic...