A5103237210- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
- SARS-CoV-2 detection and testing
- Extracellular vesicles in disease
- Bioactive Compounds and Antitumor Agents
- Reproductive tract infections research
- Metabolomics and Mass Spectrometry Studies
- Crystallization and Solubility Studies
- E-Learning and Knowledge Management
- Infective Endocarditis Diagnosis and Management
- Insect symbiosis and bacterial influences
- Physiological and biochemical adaptations
- Linguistic Studies and Language Acquisition
- Otolaryngology and Infectious Diseases
- Health, Education, and Physical Culture
- Sulfur Compounds in Biology
- Insect and Pesticide Research
- Nigella sativa pharmacological applications
- Neonatal and Maternal Infections
University of Concepción
2016-2025
San Sebastián University
2021-2025
Universidad Santo Tomás
2023
Instituto de Salud Pública de Chile
2012-2021
Hospital Regional de Concepción
2021
Ateneo de Manila University
2018
Hospital Universitario Virgen de la Arrixaca
2012-2013
Abstract Oral squamous cell carcinoma (OSCC) is the most common manifestation of oral cancer. It has been proposed that periodontal pathogens contribute to OSCC progression, mainly by their virulence factors. However, main pathogen and its mechanism modulate cells remains not fully understood. In this study we investigate host-pathogen pathways in computational proteomics behind cancer progression microbiome. The were analyzed secretome biopsies from patients with healthy controls mass...
Introduction: Extracellular vesicles (EVs) are secreted from all types of cells and involved in the trafficking proteins, metabolites, genetic material cell to cell. According their biogenesis physical properties, EVs often classified as small (including exosomes) or large EVs, oncosomes. A variety methods used for isolated EVs; however, they have several limitations, including vesicle deformation, reduced particle yield, co-isolate protein contaminants. Here we present an optimized fast...
We report the first description of a rare catalase-negative strain Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples pediatric patient. Sequencing analysis revealed that this is related to ST10 strain, which has earlier been described relation S. carriers. Interestingly, sequence catalase gene katA presence novel nonsense mutation causes premature translational truncation C-terminus enzyme leading loss 222 amino acids. Our study suggests...
A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy antibiotics and reducing therapeutic arsenal available for treatment infectious diseases. In present study, we developed a new class compounds with antibacterial activity obtained by simple, two step synthesis screened products in vitro against ATCC® strains using broth microdilution method. The exhibited minimum inhibitory concentrations (MIC) 1⁻32 μg/mL Gram-positive strains. structure⁻activity...
Community associated-methicillin-resistant Staphylococcus aureus (SAMR-AC): comunication of the first four pediatric cases in Roberto del Rio Children´s HospitalStaphylococcus is a known pathogen patients that produces skin infections, cutaneous abscess, cellulitis and osteoarticular infections.Most these infections are produced by meticilin susceptible strain.The community associated methicillin resistant was published for time 1993, ever since then has been recognized as cosmopolite...
There is an urgent need for the development of new antibiotics. Here, we describe inhibitory activity quinone compounds against methicillin-resistant Staphylococcus aureus (ATCC® 43300), methicillin-sensitive S. 29213), and two clinical isolates from Chile (ISP-213 ISP-214). We observed 99.9% reduction in viability within 2 h exposure without cultures exhibiting any post-antibiotic effect, which was twice kinetics to that with vancomycin. These did not acquire resistance these derivatives...
Neisseria meningitidis is a human exclusive pathogen that can lead to invasive meningococcal disease or may be carried in the upper respiratory tract without symptoms. The relationship between carriage and remains poorly understood but it widely accepted decreasing by immunization should reduction of cases. Latin America has experienced an increased incidence serogroup W cases last decade. Specifically Chile, despite low total cases, become predominant since 2011 been associated with...
Isolation of Staphylococcus aureus hetero-resistant to vancomycin (hVISA) in the Regional Hospital Concepción, ChileMethicillin-resistant (MRSA) is widely distributed hospital environments, causing serious infections, mainly bloodstream, surgical site infection and pneumonia.Vancomycin (VAN) antibiotic choice for treating severe MRSA infections; however, nowadays worldwide resistant strains (VRSA), with intermediate susceptibility (VISA) decreased or hetero-resistance VAN have been reported,...
In January 2021, the Chilean city of Concepción experienced a second wave coronavirus 2019 (COVID-19) while in early April entire country faced same situation. This outbreak generated need to modify and validate method for detecting severe acute respiratory syndrome 2 (SARS-CoV-2) saliva, thereby expanding capacity versatility testing COVID-19. study was conducted February 2021 during which time, town under total quarantine. The participants were mostly symptomatic (87.4%), not hospitalized,...
Acute myocardial infarction (AMI) results from vulnerable plaque rupture, causing ischemic cardiomyocyte necrosis and intense inflammation. Paradoxically, this inflammation releases factors that aid heart repair. Recent findings suggest a role for extracellular vesicles (EVs) in intercellular communication during post-AMI cardiac However, EVs' tissue origin chemokine profile the blood of patients with AMI remains unclear. This study characterized receptor EVs coronary peripheral AMI. The...