A5026362678- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Advanced MRI Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac pacing and defibrillation studies
- Pericarditis and Cardiac Tamponade
- Ultrasound in Clinical Applications
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Cardiomyopathy and Myosin Studies
- Explainable Artificial Intelligence (XAI)
- Electrohydrodynamics and Fluid Dynamics
- Shoulder Injury and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Coronary Artery Anomalies
Politecnico di Milano
2015-2025
International Flame Research Foundation
2009-2023
Fondazione A.R. Card Onlus
2014-2020
Bioengineering Technology and Systems (Italy)
2017-2019
University of Milan
2017
NorthEast Regional Epilepsy Group
2016
Research Network (United States)
2016
Luigi Sacco Hospital
2015
Bioengineering Center
2009
Transcatheter aortic valve implantation (TAVI) can treat symptomatic patients with calcific stenosis. However, the severity and distribution of calcification leaflets impair TAVI efficacy. Here we tackle this issue from a biomechanical standpoint, by finite element simulation widely adopted balloon-expandable in three models representing root different scenarios We developed modeling approach realistically accounting for pressurization complex anatomy, detailed patterns, actual stent...
Although associated with left heart pathologies, functional tricuspid regurgitation (FTR) is often untreated during surgery. Hence, owing to its degenerative character, reoperation needed, encompassing an impressive (25% 35%) mortality rate. Thus transcatheter approaches FTR are raising great interest. The authors evaluated the post-treatment effectiveness of edge-to-edge technique using percutaneous mitral valve repair device in ex vivo pulsatile model FTR. devices were implanted 11 porcine...
Abstract Purpose Aortic valve stenosis (AVS) is the most common valvular disease in developed countries. Surgical or transcatheter bioprosthetic aortic (AV) replacement standard treatment for severe AVS. However, bioprostheses are prone to structural degeneration. Hence, terms of lifetime management, there a need therapies that can postpone AV replacement. With aim fragmenting calcifications and restoring leaflets flexibility, new debridement device (TDD) exploiting ultrasound under...
In aortic valve repair, reduction and stabilization of the ventriculo-aortic junction (VAJ) is generally recommended. this in vitro study, we compare three techniques annuloplasty: subcommissural annuloplasty (SCA), internal ring (IR) external (ER) annuloplasty. Ten fresh porcine preparations were tested a pulsatile mock loop. Each sample was untreated (baseline: B). The then performed successively each sample. technique tested, removed following performed. SCA applied at 50% interleaflet...
Abstract A pulsatile mock loop system was designed and tested. This prototype represents a versatile, adjustable, controllable experimental apparatus for in vitro studies of devices meant to interface with the human circulatory system. The pumping consisted ventricular chamber featuring two biomorphic silicone valves as inlet outlet valves. volume is forced by piston pump moved computer‐controlled, low‐inertia motor. Fluid dynamic tests device were performed simulate physiological conditions...
The aortic root functional unit (ARFU) is a complex structure whose functions are strictly dependent on the biomechanical interaction among each of its anatomically defined elements. classical approach to in vitro study hydrodynamics does not take this complexity into account. We propose novel methodology based possibility house whole natural ARFU samples purposely designed pulsatile mock loop, allowing for surgery simulation. To point out usability and potentialities device, loop was tested...
We developed a new pulsatile hydrodynamic simulator for the in vitro testing of mitral valve (MV) samples. The required specifications included 3D positioning system papillary muscles (PMs) that is accurate and simple to manage; measurement force exerted by chordae tendineae on PMs; possibility visually inspect MV kinematic analysis.An atrial/ventricular chamber was developed. ventricular housed tri-axial actuator aligned morphometric Cartesian frame, allowing PM even while tests are...
Objective: Aortic interleaflets triangles annuloplasty (AITA) reduces interleaflet triangles’ circumferential extent through properly placed sutures. To achieve aortic root functional unit (ARFU) stabilization, we aimed at quantifying the effect of suture (SE) on valve function and finding general optimization criteria. Methods: A previously published ARFU finite element model was modified to simulate dilation AITA, systematically varying SE corresponding regurgitant orifice (RO), leaflets...
Small-sized aortic bioprostheses may cause high postoperative gradients. In clinical practice, it is difficult to compare from different manufactures, owing the discrepancy between true size and nominal of prosthesis inter-patient variability in root characteristics. vitro studies provide accurate data, using a system which possible implant should enable fair comparison be made. The present study compared four most widely used pericardial stented manufacturers surgically implanted small...
Percutaneous pulmonary valve implantation is a potential treatment for right ventricular outflow tract (RVOT) dysfunction. However, RVOT site varies among subjects and the success of procedure depends on morphology selection. The aim this study was to use in vitro testing establish percutaneous competency different previously defined morphologies. Five simplified geometries (stenotic, enlarged, straight, convergent, divergent) were manufactured by silicone dipping. A mock bench developed...
Currently, clinicians are seeking new, minimally invasive treatment options for functional tricuspid regurgitation (FTR). Challenging complexity requires the evaluation of techniques in adequate and realistic preclinical scenario. The purpose this article is to describe design assessment a novel passive beating heart model pulmonary circulation with possibility tightly control FTR. housed porcine hearts actuated by volumetric pump that cyclically pressurized right ventricle. in-vitro FTR...
Background Stentless valves have long been considered the ideal in terms of hemodynamics. Recently, Trifecta valve, a stented bioprosthesis with excellent fluid dynamic characteristics, has become available. The aim study was to compare opening/closing pattern Freestyle stentless valve and that native aortic valve. Methods A total 12 patients 10 were compared normal control patients. Leaflet kinematics hemodynamic parameters obtained by echocardiographic M-mode Doppler measurements. Results...