A5050480817- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Petroleum Processing and Analysis
- Advanced Neuroimaging Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Mental Health Research Topics
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Bioactive Compounds and Antitumor Agents
- Pain Management and Placebo Effect
- Mindfulness and Compassion Interventions
- Musculoskeletal synovial abnormalities and treatments
- HIV, TB, and STIs Epidemiology
- Corrosion Behavior and Inhibition
- Diagnosis and Treatment of Venous Diseases
- Liver physiology and pathology
- Neurological Disease Mechanisms and Treatments
- Adolescent Sexual and Reproductive Health
- Technology Use by Older Adults
- Organ Transplantation Techniques and Outcomes
- Vagus Nerve Stimulation Research
- ECG Monitoring and Analysis
Sun Yat-sen Memorial Hospital
2013-2024
Sun Yat-sen University
2013-2024
Peking University
2010-2023
Peking University Sixth Hospital
2010-2023
China Medical University
2019-2022
Nanjing University of Chinese Medicine
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Hospital of Stomatology, Sun Yat-sen University
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
Stomatology Hospital
2021
Background: Papillary thyroid carcinoma (PTC) is the predominant form of cancer globally, especially when lymph node metastasis (LNM) occurs. Molecular heterogeneity, driven by genetic alterations and tumor microenvironment components, contributes to complexity PTC. Understanding these complexities essential for precise risk stratification therapeutic decisions. Methods: This study involved a comprehensive analysis 521 patients with PTC from our hospital 499 The Cancer Genome Atlas (TCGA)....
Abstract Objective This prospective observational cohort real-world study evaluates and compares the efficacy prognosis of ultrasound gene-based microwave ablation (MWA) surgical treatment in patients with low-risk papillary thyroid carcinoma (PTC), emphasizing influence genetic mutations on patients’ selection. Background MWA, a minimally invasive technique, is increasingly recognized management PTC. While traditional criteria for focus tumor size, number, location, impact remains...
Abstract Background The human liver possesses a remarkable capacity for self‐repair. However, fibrosis remains serious medical concern, potentially progressing to end‐stage cirrhosis and even death. Liver is characterized by excess accumulation of extracellular matrix in response chronic injury. regenerative ability, strong indicator health, important resisting fibrosis. In this study, we provide evidence that ursodesoxycholic acid (UDCA) can alleviate promoting regeneration via activation...
Abstract Bipolar disorder (BPD) is often confused with major depression, and current diagnostic questionnaires are subjective time intensive. The aim of this study was to develop a new Diagnosis Checklist in Chinese (BDCC) by using machine learning shorten the Affective Disorder Evaluation scale (ADE) based on an analysis registered multisite cohort data. In order evaluate importance each item ADE, case-control 360 bipolar patients, 255 depressive (MDD) patients 228 healthy (no psychiatric...
Morinda officinalis oligosaccharides (MOs) are natural herbal extracts that have been shown to exert antidepressant effects. However, the mechanism of this effect remains unclear. Here, we explored by which MOs improved experimental depression. Using a chronic mild stress (CMS) murine model, examined whether could protect against depressive-like behaviour. Lipopolysaccharide (LPS)- and ATP-treated BV2 cells were used examine potential mediate inflammatory response. We found prevented...
This study was designed to evaluate the microstructural integrity of white matter (WM) in amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD) among Han Chinese elderly using diffusion tensor imaging (DTI) technique, investigate relationship between WM abnormalities dysfunction. Sixty-four subjects (23 probable AD, 20 MCI, 21 age-matched normal controls) who did not have visible lesion burden were analyzed. Fractional anisotropy (FA) mean diffusivity measured...
Osteoradionecrosis of the jaw (ORNJ) is one most common and serious complications after radiotherapy head neck malignancies due to high incidence nasopharyngeal cancer in Southern China. Clinicians lack understanding consensus on anti-infective treatment ORNJ lesions. This research aims provide evidence for rational use antibiotics by reviewing bacterial spectrums antimicrobial susceptibility test patients.We collected patient who was diagnosed with from November 2012 June 2019 our hospital....
Objectives To compare neurocognitive function in patients with bipolar depression typeⅠ (BD),recurrent unipolar (UD) and schizophrenia (SZ).And try to explore the relationship between neuropsychological clinical features bipolar. Methods 29 BD,25 UD,30 SZ were consecutively recruited from clinics wards of Peking University Sixth Hospital September 2010 April 2011,also including 30 controls community.Four groups participants diagnosed by SCID-Ⅰ/P (structured interview for DSM-Ⅳ-TR...
<p indent="0mm">By 2030, depression is expected to become a global economic burden due its serious effect on people’s physical and mental health. According LeMoult Gotlib’s cognitive theory of depression, individuals with have executive function defects, which lead negative processing bias increased use non-adaptive emotional regulation strategies such as rumination. Beevers’ dual vulnerability more automatic less reflective processing, results in bad mood cycles. This review suggests that...
Many previous studies have noticed obvious alterations in different white matter tracts among patients with major depressive disorder (MDD). Growing evidence also strongly suggest a role of leptin the pathogenesis MDD, but conflicting results levels. However, no examined relationship between and integrity MDD. Therefore, we aimed this study to investigate plasma levels both drug-naïve medicated MDD patients. We measured using diffusion tensor imaging (DTI) voxel-based analysis (VBA) 140...
Objectives To compare the sleep parameters and certain neurocognitive tasks between patients with unipolar bipolar depression,and to explore correlation pattern cognitive function. Methods Fifteen depression,thirteen fifteen health controls were recruited.Sleep recorded by polysomnography for three groups respectively.The finished in group. Results Compared control group,the had longer latency (P=0.004),poorer efficiency (P=0.007),while poorer (P=0.038),less slow wave...
Objective: To investigate the willingness to use three types of pre-exposure prophylaxis (PrEP) and its associated factors among MSM in Chengdu. Methods: A total 793 were recruited through Chengdu Tongle Health Consultation Service Centre between November 2021 January 2022. Data collected, including demographic characteristics, sexual behaviors last six months, PrEP-related stigma, HIV anticipated internalized PrEP. Univariate multivariate logistic regression models conducted using Results:...
Objective To evaluate the effect of nutrition diets on rats and compare steatosis metabolic phenotype in liver.Methods Male LEWs were fed with low methionine/choline + high starch diet (FLD),low fat (MCD HF),methionine-choline deficient (MCD) standard (NC) for 1,2,4,6 weeks 3 months.Hepatic steatosis,liver enzymes,histological features,lipid peroxidation products (LPO) glutathione (GSH) measured.Results MCD caused severe body weight loss (30％) steatosis.A substantial release ALT was...
Objective: To investigate the association between response to repeated negative HIV testing and risk sexual behaviors in men who have sex with (MSM) Chengdu. Methods: A total of 610 MSM were recruited by convenience sampling method through Chengdu Tongle Health Consultation Service Centre from March May 2022. Data collected questionnaire survey, including demographic characteristics, past 6 months, rerpeated testing. Univariate multivariate logistic regression models conducted analyze...
Objectives To assess the effect of onset age on prefrontal activation during a working memory task in patients with bipolar disorder using 52 multichannel functional near-infrared spectroscopy (NIRS). Methods Sixteen early-onset (EO, age≤24 years old) and 14 non-early-onset (NEO, age>24 Ⅰ were consecutively recruited from wards Peking University Sixth hospital between October 2013 May 2014, also including 16 healthy controls (HC) community. Three groups participants diagnosed MINI,...
Background: Dimensional psychopathology and its neurobiological underpinnings could provide important insight into the major psychiatric disorders (MPDs), including depressive disorder (MDD), bipolar (BPD), schizophrenia (SCZ). In this study, we examined symptoms their relationship with functional connectivity (FC) leptin across MPDs.Methods: A total of 728 participants [healthy controls (HC), n = 325; MDD, 153; BPD, 123; SCZ, 127] underwent resting state magnetic resonance imaging at a...