A5105409572- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Protein Hydrolysis and Bioactive Peptides
- GDF15 and Related Biomarkers
- TGF-β signaling in diseases
- Cytokine Signaling Pathways and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Neuropeptides and Animal Physiology
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Bone health and treatments
- Ion Transport and Channel Regulation
- Lysosomal Storage Disorders Research
- Bone and Dental Protein Studies
- Aquaculture Nutrition and Growth
- Nutrition and Health in Aging
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- RNA Interference and Gene Delivery
- Diabetes and associated disorders
- Cellular transport and secretion
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
Vita-Salute San Raffaele University
2005-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2016
University of Milan
2009-2015
United States Bone and Joint Initiative
2009-2010
San Raffaele University of Rome
2007-2009
Transgenic mice over-expressing calcitonin gene-related peptide (CGRP) in osteoblasts have increased bone density due to formation, thus suggesting that CGRP plays a role metabolism. In this study we determined the relationship between CGRP, canonical Wnt signaling and apoptosis human (hOBs) consideration of well-documented involvement pathway cells. Primary cultures hOBs were treated with 10(-8) M. Levels β-catenin, which is cytoplasmic protein mediator signaling, mRNA determined. increases...
It is presently thought that osteoprotegerin (OPG) a cytokine involved in the regulation of osteoblast/osteoclast crosstalk and maintenance bone mass. Recent studies showed GH replacement therapy GH-deficient patients was able to induce significant increase OPG plasma, as well cortical trabecular bone. In order determine whether could directly modulate secretion, effect on human osteoblast-like cells (hOB) primary culture studied. After detecting presence mRNA for receptor (GHR) by RT-PCR,...
Recent research suggests a role for ghrelin in the modulation of inflammatory disorders. However, type receptor (GHS-R) involved both anti-inflammatory and anti-hyperalgesic actions remains to be characterized. In this study, we examined whether inhibitory effect development hyperalgesia edema induced by intraplantar carrageenan administration depends on an interaction with GHS-R1a. Both central (1 nmol/rat, i.c.v.) peripheral (40 nmol/kg, i.p.) selective GHS-R1a agonist EP1572 had no...
<i>Background and Aim:</i> TLQP-21, a peptide derived from the <i>vgf </i>gene, has been reported to play role in regulation of rat gastric motility, but its influence on mucosal integrity is unknown. <i>Experimental Approach:</i> We investigated effects central (0.8–8 nmol/rat) or peripheral (48–240 nmol/kg) TLQP-21 administration ethanol- (EtOH, 50%, 1 ml/rat) induced lesions rat. The mechanisms involved such activity were also examined....
Ghrelin, by binding growth hormone secretagogue receptor (GHS-R), promotes osteoblast proliferation but the signaling mechanism of GHS-R on these cells remains unclear. Since canonical Wnt/ β -catenin pathway is critically associated with bone homeostasis, we investigated its involvement in mediating ghrelin effects osteoblasts and osteoblast-osteoclast cross talk. Ghrelin (10 −10 M) significantly increased levels rat (rOB). This stimulatory action involves a specific interaction GHS-R1a, as...
Wnt signaling, a major regulator of bone formation and homeostasis, might be involved in the loss osteoporotic patients consequent impaired response to fracture. Therefore we analyzed Wnt-related, osteogenic, adipogenic genes tissue elderly postmenopausal women undergoing hip replacement for either femoral fracture or osteoarthritis. Bone specimens derived from intertrochanteric region femurs 25 with (F) 29 osteoarthritis without (OA) were analyzed. Specific miRNAs matched blood samples....