A5058401142- PARP inhibition in cancer therapy
- Surgical Simulation and Training
- Prostate Cancer Diagnosis and Treatment
- Innovations in Medical Education
- Dental Education, Practice, Research
- Anatomy and Medical Technology
- Prostate Cancer Treatment and Research
- Diversity and Career in Medicine
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Clinical practice guidelines implementation
- COVID-19 and healthcare impacts
- Medical and Biological Sciences
- Ovarian cancer diagnosis and treatment
- Nanoplatforms for cancer theranostics
- Electrostatic Discharge in Electronics
- Appendicitis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Advances in Oncology and Radiotherapy
- Conferences and Exhibitions Management
- Sex and Gender in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Dermatologic Treatments and Research
- Intraperitoneal and Appendiceal Malignancies
- Integrated Circuits and Semiconductor Failure Analysis
Barrow Neurological Institute
2023-2025
University College London
2015-2024
JSS Academy of Higher Education and Research
2024
Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College
2024
Michigan Center for Translational Pathology
2023
University of Michigan
2023
Yale University
2023
University Hospital Southampton NHS Foundation Trust
2023
Loyola University Medical Center
2019-2022
Loyola University Chicago
2022
Abstract Background: Brain penetrant histone deacetylase inhibitors (HDACi) are promising radiosensitizing agents for glioblastoma (GBM). In addition to suppression of HDAC activity, the antiproliferative effect HDACi includes downregulation DNA damage repair (DDR) pathway and persistent damage. Here, we evaluated synergistic combining enzyme, ataxia telangiectasia mutated (ATM) inhibitors, quisinostat (QST) AZD1390 broaden therapeutic window GBM treatment. Methods: vitro dose-response...
Salvage robot-assisted radical prostatectomy (sRARP) is a potential treatment option for locally recurrent prostate cancer (PCa) after nonsurgical primary treatment. There are minimal data comparing outcomes between propensity-matched sRARP and (RARP).The objective to compare perioperative, oncological, functional of with RARP, the secondary whole focal gland therapy.A 1:1 comparison was carried out 135 cases RARP from cohort 3852 consecutive patients high-volume tertiary...
Mentoring is critically important for the personal and professional development of a surgeon. Early career stage mentoring by same-gender role models may help ameliorate gender imbalance in surgery based on our understanding barriers women pursuing surgical careers. A novel method establishing these relationships speed mentoring. This study aims to examine impact one-day speed-mentoring session with same mentors cohort's perceptions surgery.This prospective pre-post compared attitudes before...
There are various methods advocated for the treatment of verruca plantaris. However, many verrucas do not respond to simple treatment.This study presents our results using Nd: YAG laser ablation therapy such recalcitrant cases.We performed a retrospective audit by sending questionnaire all patients with who had been treated Nd:YAG over previous 12 months. The asked whether successful, successful but new lesions emerged, partially improvement or unsuccessful. A Fontana was used at following...
Knowledge gaps remain about how the Ryan White human immunodeficiency virus (HIV)/AIDS Program (RW) contributes to health outcomes. We examined association between different RW service classes and retention in care (RiC) or viral suppression (VS).
Abstract Background: Aggressive meningiomas (WHO grade II/III) are incurable brain tumors and despite surgery radiation therapy, recur frequently without approved systemic treatment options. Hence, there is an unmet need for targeted inhibition therapy biomarkers that predict vulnerability to therapies in aggressive meningioma patients. Hippo signaling pathway has been shown be dysregulated meningioma, resulting activation of its target TEAD as a transcriptional factor. We hypothesize...
You have accessJournal of UrologyDiversity, Equity & Inclusion: Increasing Representation in Urology (MP54)1 May 2024MP54-12 ASSESSING GENDER DISPARITY AND 'MANEL' TRENDS IN UROLOGICAL SURGERY CONFERENCES: A SIX-YEAR RETROSPECTIVE COHORT STUDY Aqua Asif, Maria Georgi, Kristie Hing Chi Leung, Monty Fricker, Sonam Patel, Arslan Khaliq Raja, Alice Gargan, Kate Katherine Lee, Oliver E. Burton, Ria Kamboj, Ashviniy Thamilmaran, Zakee Abdi, Sharmi Haque, Fontaine Tse, Caroline M. Moore, and Arjun...
Identification of host determinants coronavirus infection informs mechanisms pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes diverse coronaviruses, including SARS-CoV, SARS-CoV-2, MERS-CoV mouse hepatitis virus (MHV) in a activity-independent manner. Mechanistic studies reveal viral entry by regulating expression multiple receptors, ACE2 , DPP4 Ceacam1 . Importantly, TPR domain is required for recruitment...
Abstract Robotic surgery training has lacked evidence-based standardisation. We aimed to determine the effectiveness of adjunctive interactive virtual classroom (VCT) in concordance with self-directed Fundamentals Surgery (FRS) curriculum. The is comprised a studio multiple audio–visual inputs which participants can connect remotely via BARCO weConnect platform. Eleven novice surgical trainees were randomly allocated two groups (A and B). In week 1, both completed robotic skills induction....
There is a strong association between depression and anxiety. Duloxetine, an antidepressant agent, also used in the treatment of Hydroxyzine preferred over benzodiazepines Present study was designed to impact combination duloxetine with hydroxyzine anxiety.Mice received intraperitoneal injection normal saline (10 ml/kg), alone mg/kg), plus (5 mg/kg, each).The vivo results (elevated maze light/dark transition tests) showed significant anxiolytic activity than control group. The brain...
There is a strong association between depression and memory impairment. The present study aims to assess the nootropic activity of duloxetine piracetam combination. Male Swiss Albino mice were divided randomly into 4 groups. Treatment normal saline (10 ml/kg), mg/kg), (100 (5 mg/kg) plus (50 given through intra-peritoneal route group I-IV, respectively. Transfer latency in elevated maze (EPM) time spent target quadrant Morris water (MWM) recorded. Estimation brain monoamines hippocampus,...
Abstract Background: Valproic acid (VPA) is an FDA-approved anti-seizure medication that has been demonstrated to have anti-tumor and radiosensitization effect on multiple cancer cells including aggressive brain cancer, glioblastoma (GBM). VPA thought exert its effects in part through inhibition of histone deacetylases (HDACs), upregulation apoptosis autophagy, disruption DNA repair mechanisms. Overall survival patients treated with combination TMZ radiation therapy (RT) was significantly...
Abstract Background: Insufficient drug concentrations reaching the brain-localized tumor tissue remains one of major challenges in treatment glioblastoma (GBM). An intranasal (IN) formulation NEO100 (NeOnc Technologies, Inc., Los Angeles), a highly purified version perillyl alcohol, has been recently reported to enhance brain upon IN co-delivery. Here, we report detailed pharmacokinetics (PK) and analysis quantitatively examine extent increase after administration. Furthermore, also...