A5101972960- Tissue Engineering and Regenerative Medicine
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Cardiac Fibrosis and Remodeling
- Electrospun Nanofibers in Biomedical Applications
- Exercise and Physiological Responses
- Hydrogen's biological and therapeutic effects
- Graphene and Nanomaterials Applications
- Cardiac Ischemia and Reperfusion
- Cardiovascular Health and Risk Factors
- Heart Failure Treatment and Management
- Histone Deacetylase Inhibitors Research
- Chronic Kidney Disease and Diabetes
- Neuroscience and Music Perception
- Occupational and environmental lung diseases
- Diabetes Management and Education
- Vasculitis and related conditions
- Folate and B Vitamins Research
- Psychosomatic Disorders and Their Treatments
- Liver Disease Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Occupational exposure and asthma
- Inhalation and Respiratory Drug Delivery
- Sirtuins and Resveratrol in Medicine
Zhejiang University
2020-2024
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Nantong University
2021
Lanzhou University
2018-2021
Zhongda Hospital Southeast University
2021
Chongqing Medical University
2021
University of Rochester
2021
Computational Physics (United States)
2021
North Carolina State University
2021
The excessive reactive oxygen species (ROS) and hypoxia deteriorate the inflammation-related diseases such as myocardial infarction (MI), thereby deter normal tissue repair recovery further lead to severe fibrosis malfunction of tissues organs. In particular, MI has become one leading causes death nowadays. this study, a novel type injectable hydrogel with dual functions ROS scavenging O2 generating is fabricated for treatment in vivo. formed within 3 s from synthetic ROS-cleavable...
The modulation of inflammation in tissue microenvironment takes an important role cartilage repair and regeneration. In this study, a novel hybrid scaffold was designed fabricated by filling reactive oxygen species (ROS)-scavenging hydrogel (RS Gel) into radially oriented poly(lactide-co-glycolide) (PLGA) scaffold. PLGA scaffolds were through temperature gradient-guided phase separation freeze-drying method. RS Gel formed crosslinking the mixture ROS-responsive hyperbranched polymers...
This study aimed to track and evaluate the effect of low-dose irisin on browning white adipose tissue (WAT) in mice using magnetic resonance imaging (MRI) noninvasively vivo. Mature adipocytes extracted from were cultured, induced characterized before being treated by irisin. The volume fat fraction WAT quantified MRI normal chow diet high after injection cultured validated immunohistochemistry western blotting for uncoupling protein 1 (UCP1) deiodinase type II (DIO2). serum indexes examined...
Abstract To investigate the fear of hypoglycaemia in patients with type 2 diabetes mellitus (T2DM), to identify factors related this fear, and thus provide evidence for clinical assessment. A total 385 T2DM who were admitted departments endocrinology five tertiary grade-A hospitals Chongqing, China included study. questionnaire general information a Chinese version Hypoglycemia Fear Survey (HFS) used collect data. The average score on HFS was 71.67 ± 17.06 (HFS-W 38.15 10.57; HFS-B 33.52...
Abstract Background To study the association between anthropometric measurements and risk of diabetes impaired fasting glucose (IFG) compare body mass index (BMI), waist circumference (WC), waist‐to‐height ratio (WHtR) to determine best indicator its optimal cutoffs for predicting type 2 IFG. Methods A Chinese prospective (2011‐2019) cohort named Jingchang that included 48 001 participants was studied. Using Cox proportional hazard models, ratios (HRs) incident or IFG per 1 SD change in BMI,...
Several histone deacetylase (HDAC) inhibitors have been shown to play beneficial roles in treating obesity and its related metabolic syndromes. However, the underlying mechanisms are still not understood well. In this study, we examined potential of SAHA, a potent inhibitor HDACs, on energy expenditure explored molecular mechanism involved. Our data showed that SAHA induces less lipid accumulation smaller droplets cultured adipocytes. vivo studies showing reduces body weight gain increases...
To identify the critical genes in onset and progression of Immunoglobulin A nephropathy (IgAN) to explore its immune cell infiltration feature.Differentially expressed (DEGs) were firstly screened from 1 blood-derived dataset GSE73953 a glomerulus derived GSE93798 through limma analysis, overlap omitting weighted gene correlation network analysis (WGCNA) further reduced according expression pattern with clinical features: eGFR proteinuria, followed by external validation using GSE37460 an...
Objective: To explore the relationship between lipid indicators and incidence of diabetes, to compare diabetes prediction identification power traditional combined indicators, in order best alternative for identifying predicting diabetes. Methods: Based on Jinchang cohort, a nested case-control study was conducted 1 025 new cases after excluding patients with malignant tumor related endocrine, circulatory system disease, then an age (±2 years), gender matched 1∶1 control group set analyze...
We aimed to study the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) risk model's prognostic value and relationship with left ventricular remodeling dilated cardiomyopathy.Dilated cardiomyopathy patients were prospectively recruited underwent clinical assessments. MAGGIC score was calculated. Patients followed up for adverse events echocardiography. Primary endpoints all-cause mortality first rehospitalization due heart failure. Secondary endpoint defined as a decline ejection...
Objective: To investigate the incidence and rank of chronic obstructive pulmonary disease pneumoconiosis to workers in different occupational positions Jinchang Cohort. Methods: In January 2014, a cohort follow-up population jinchang city was taken as research object, 17843 individuals among populations Cohort Study, removed with before 2013, counted new diagnosed by A-Class hospital Grade III City, Gansu Province, investigation objects rate & pneumoconiosis. The statistical significance...
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