A5009924587- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Plant Disease Resistance and Genetics
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Horticultural and Viticultural Research
- Connective tissue disorders research
- Protein Degradation and Inhibitors
- Genomics and Phylogenetic Studies
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Plant nutrient uptake and metabolism
- Chromosomal and Genetic Variations
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Moyamoya disease diagnosis and treatment
- Glioma Diagnosis and Treatment
- Identification and Quantification in Food
- Pituitary Gland Disorders and Treatments
- Circular RNAs in diseases
- Neurological Complications and Syndromes
Inner Mongolia People's Hospital
2022-2025
Henan Provincial People's Hospital
2025
First Affiliated Hospital of Zhengzhou University
2024-2025
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Harbin Medical University
2022-2024
Weatherford College
2023
State Key Laboratory of Earth Surface Processes and Resource Ecology
2021-2023
Yahoo (United Kingdom)
2023
Beijing Normal University
2021-2023
Rice blast caused by Magnaporthe oryzae is one of the most destructive diseases rice worldwide. The fungal pathogen notorious for its ability to overcome host resistance. To better understand genetic variation in nature, we sequenced genomes two field isolates, Y34 and P131. In comparison with previously laboratory strain 70-15, both isolates had a similar genome size but slightly more genes. Sequences from were used improve assembly gene prediction 70-15. Although overall structure similar,...
Increasing evidence has demonstrated that pyroptosis, a type of inflammatory programmed cell death, plays an important role in the pathogenesis and progression gastric cancer. However, it remains unclear whether pyroptosis-related long non-coding RNAs (lncRNAs) can be used to predict diagnosis prognosis adenocarcinoma. This study aimed evaluate test lncRNA signature associated with pyroptosis as prognostic tool for stomach adenocarcinoma (STAD) ascertain their immune value. Relative...
Schistosomiasis japonicum remains a considerable economic and public health concern in China, the Philippines Indonesia. Currently available measures to control unique intermediate host Oncomelania hupensis are frequently associated with severe side effects. Previous studies have demonstrated that linalool-rich extracts from various plants exhibited promising biological activities including cytotoxic, anti-microbial anti-parasitic properties.We identified components of leaf Cinnamomum...
Abstract Although hybridization plays a large role in speciation, some unknown fraction of hybrid individuals never reproduces, instead remaining as genetic dead-ends. We investigated morphologically distinct and culturally important Chinese walnut, Juglans hopeiensis, suspected to have arisen from Persian walnut (J. regia) with Asian butternuts cathayensis, J. mandshurica, hybrids between cathayensis mandshurica). Based on 151 whole-genome sequences the relevant taxa, we discovered that all...
Esophageal cancer presents significant challenges due to the limited efficacy and severe side effects associated with conventional treatments. The identification of epigenetic regulatory molecules that are aberrantly expressed in tumors is crucial for elucidating mechanisms underlying development progression esophageal cancer. We performed high-throughput methylation level analysis on cancerous adjacent tissues from 25 patients, identifying differentially methylated gene ZC3H18 utilizing...
ABSTRACT MicroRNAs (miRNAs) are crucial factors in gene regulation, and their dysregulation plays important roles the immunity of gastric cancer (GC). However, finding specific effective miRNA markers is still a great challenge for GC immunotherapy. In this study, we computed analysed miRNA‐seq, RNA‐seq clinical data patients from TCGA database. With comparison tumour normal tissues GC, identified 2056 upregulated 2311 downregulated protein‐coding genes. Based on miRNet database, more than...
Calcium carbonate (CaCO3) has been widely studied as a drug delivery system (DDS), but it still some limitations in its clinical application tumor chemotherapy, such difficult industrialization, complex synthesis methods, time-consuming and labor-intensive, low loading. Here, we developed an industrialized method for the simple, rapid controllable of high drug-loaded vaterite hollow CaCO3 (VHC). The VHC was successfully prepared by adding L-Leucine (Leu) process preparing industrial method....
The complete mitochondrial genome of Shorthead catfish (Pelteobagrus eupogon) was obtained by DNA sequencing based on the PCR fragments. entire 16,562 bp in length, with a gene content 13 protein-coding, 2 ribosomal RNA, and 22 transfer RNA genes, order identical to that observed most other vertebrates. Those genes are arranged compactly no introns few intergenic nucleotides. Molecular data here presented provide useful toll for evolutionary as well population genetic studied.
Abstract Background Autopolyploidy is a valuable model for studying whole-genome duplication (WGD) without hybridization, yet little known about the genomic structural and functional changes that occur in autopolyploids after WGD. Cyclocarya paliurus (Juglandaceae) natural diploid–autotetraploid species. We generated an allele-aware autotetraploid genome, chimeric chromosome-level diploid resequencing data 106 individuals at average depth of 60 × per individual, along with 12 90 individual....
Tacrolimus (TAC), a first-line immunosuppressant in solid-organ transplant, has narrow therapeutic window and large inter-individual variability, which affects its use clinical practice. Successful predictions using machine learning algorithms have been reported several fields. However, comparison of 10 model-based TAC pharmacogenetic pharmacokinetic dosing for kidney transplant perioperative patients Chinese descent not reported. The objective this study was to screen establish an...
As a major component of the tumor tissue, microenvironment (TME) has been proven to associate with progression and immunotherapy. Ovarian cancer accounts for highest mortality rate among gynecologic malignancies. Its clinical treatment decision is highly correlated prognosis, underscoring need evaluate prognosis choose proper through TME information.This study constructs score information obtained by CIBERSORT algorithm, which classifies patients into high low TMEscore groups quantified...
ObjectiveThe aim of this study was to elucidate the genetic pathways associated with Moyamoya disease (MMD) and syndrome (MMS), compare functional activities, validate relevant related genes in an independent dataset.MethodsWe conducted a comprehensive search for studies on MMD MMS across multiple databases identified genes. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichments analyses were performed these Commonly shared selected further validation dataset,...
Platinum resistance is a common cause of chemotherapy failure in lung adenocarcinoma (LUAD).Competing endogenous RNAs (ceRNAs), which function by competitively binding to miRNAs, can influence drug response.However, the regulatory mechanisms ceRNAs underlying chemoresistance LUAD remain largely unknown.Here, we proposed an integrated pipeline combining limma algorithm, miRNA prediction expression correlation model and experimental support identify functional lncRNA-miRNA-mRNA competing...
Epithelial ovarian cancer (EOC) is the main cause of mortality among gynecological malignancies worldwide. Although patients with EOC undergo aggregate treatment, prognosis often poor. Peritoneal malignant ascites a distinguishable clinical feature in and plays pivotal role tumor progression recurrence. The mechanisms microenvironment (TME) regulation need to be explored. We comprehensively analyzed transcriptomes 4680 single cells from five (three diagnostic samples two recurrent samples)...
To use network pharmacology to explore the mechanism of drug pair Rhubarb-Coptis in treatment diabetic nephropathy (DN).The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used screen active ingredients Rhubarb-Coptis. Targets were obtained using TCMSP and SwissTargetPrediction databases. DN disease targets extracted from Online Mendelian Inheritance Man (OMIM), GeneCards, Therapeutic Target (TTD) A "drug-compound-target" protein-protein interaction (PPI) constructed...
The complete mitochondrial DNA sequence of Pelteobagrus nitidus was determined using a PCR-based method. total length is 16,532 bp. contents the P. genome are 13 protein-coding genes, two ribosomal RNA and 22 transfer non-coding control region. Base composition entire A 31.72%, T 26.92%, C 26.45%, G 14.91%, with an A+T (58.64%) rich feature as that other vertebrate genome.
Papillary craniopharyngiomas (PCPs) are biologically benign but clinically aggressive lesions hence affect the quality of life. The expression inflammatory mediators and regulation immune microenvironment in PCPs have not been investigated much. In this study, for first time, we assessed cell infiltration signatures by analyzing bulk-RNA sequencing data immunohistochemical staining. Additionally, performed qRT-PCR analysis to detect interleukin-1α ( IL1A ) interleukin-6 IL6 different groups...
Biliary atresia (BA) is a devastating progressive fibro inflammatory disorder in infants. The exact etiology of BA still unclear. This study aimed screen key genes potentially associated with the occurrence BA. All data was obtained from GSE46960 dataset. limma package R language used for differentially expressed gene (DEG) analyses. ontology and Kyoto encyclopedia genomes enrichment analysis were performed on screened DEGs, using "clusterProfiler" package. protein-protein interaction...
Only 30-40% of advanced melanoma patients respond effectively to immunotherapy in clinical practice, so it is necessary accurately identify the response pre-clinically. Here, we develop KP-NET, a deep learning model that sparse on KEGG pathways, and combine with transfer- predict melanomas using pathway-level information enriched from gene mutation copy number variation data. The KP-NET demonstrates best performance AUROC 0.886 testing set 0.803 an unseen evaluation when predicting...