A5088089309- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Frailty in Older Adults
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Proteoglycans and glycosaminoglycans research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Pleural and Pulmonary Diseases
- Esophageal and GI Pathology
- Glycosylation and Glycoproteins Research
- Radiomics and Machine Learning in Medical Imaging
- Genetic and Kidney Cyst Diseases
- Colorectal Cancer Screening and Detection
- Pneumothorax, Barotrauma, Emphysema
- Anorectal Disease Treatments and Outcomes
- Immunotherapy and Immune Responses
- Hip and Femur Fractures
- Diabetes and associated disorders
University Medical Center Hamburg-Eppendorf
2014-2025
Universität Hamburg
2014-2025
Pediatric Nephrology of Alabama
2010
Kinderkrebs-Zentrum Hamburg
2010
Children's Clinical University Hospital
2010
Mesothelial E- and P-selectins substantially mediate the intraperitoneal spread of Pancreatic ductal adenocarcinoma (PDA) cells in xenograft models. In absence selectins host, integrin subunit alpha-V (ITGAV, CD51) was upregulated remaining metastatic deposits. Here we present first experimental study to investigate if ITGAV plays a functional role PDA tumor growth progression with particular focus on carcinomatosis.Knockdown generated using an RNA interference-mediated approach two cell...
Metastasis is a cancer-related systemic disease and responsible for the greatest mortality rate among cancer patients. Interestingly, interaction between immune system cells seems to play key role in metastasis formation target organ. However, this complex network only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 promotes cell extravasation, early step of metastasis. Based on these data, we aimed here decipher last formation. levels were increased...
Abstract Purpose Improved long-term survival after low anterior resection (LAR) for rectal cancer highlights the importance of functional outcome. Urogenital and anorectal dysfunction is frequently reported conventional LAR. Advanced minimally invasive techniques such as robotic (RoTME) transanal total mesorectal excision (TaTME) might improve results by precisely dissecting preserving autonomic nerves. We compared outcomes RoTME or TaTME in a multicenter study. Methods One hundred twenty...
Chronic kidney disease (CKD) has been increasingly shown to be a negative prognostic factor after liver transplantation (Ltx). Creatinine-based glomerular filtration rate (GFR) formulas are notoriously insensitive. In children, non-invasive determination of GFR by measurement serum cystatin C is feasible and repeatedly correlated the gold standards measurements. The aim our study was determine using (GFR(cys)) in comparison with conventional calculated creatinine clearance (GFR(crea))...
Abstract Colorectal carcinoma (CRC) is one of the most common carcinomas worldwide. Early detection crucial for reducing morbidity and mortality. Several promising studies described use midkine (MK) as a tumor marker. This study aimed to investigate larger collective ascertain if preoperative serum level (S‐MK) suitable marker screening S‐MK correlates with progression localization. It was also investigated first time whether patients high show poor survival. prospective single‐center...
Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and the number of PDAC-related deaths is rising. Recently tumour stroma in particular one its main components, hyaluronan (HA), have attracted considerable attention as intravenous hyaluronidase treatment together with conventional chemotherapy considerably prolonged survival HA-rich PDA patients. We therefore wanted to investigate prognostic significance HA deposition using both antibodies binding protein (HABP)....
BackgroundInsufficient remnant liver volume (RLV) after the resection of hepatic malignancy could lead to failure and mortality. Portal vein ligation (PVL) prior hepatectomy is subsequently introduced increase improve outcome malignancy. IL-22 has previously been reported promote regeneration, while facilitating tumor development in via Steap4 upregulation. Here we performed PVL mouse models study role regeneration post-PVL.MethodsLiver weight was measured magnetic resonance imaging (MRI)....
The role of CD10 expression in colorectal cancer has been controversially discussed the literature. Some data suggest a predictive capacity for lymph node and liver metastases, thus influencing overall survival (OS) disease-free (DFS). This study aims to analyse relationship between European cohort. To determine association with tumour phenotype, molecular features, prognosis, tissue microarray 1469 carcinomas was analysed using immunohistochemistry compared matched clinicopathologic data....
The role of the computed tomography (CT)-derived skeletal muscle index (SMI) as a parameter quantity on outcome after major liver resection remains contradictory and that radiodensity attenuation (MRA) quality has not been sufficiently evaluated. This observational study aimed to investigate influence metric SMI MRA values cut-off-based CT sarcopenia detection liver-surgery specific complications measured by new FABIB (liver failure, ascites, biliary leakage, infection, bleeding) score...
In Germany, socioeconomically deprived citizens more often develop esophageal carcinoma, since typical risk factors follow the social gradient. Therefore, we hypothesized that socioeconomic deprivation might also be associated with advanced tumor stages and comorbidities at time of surgery. As a consequence, may related to postoperative complications reduced overall survival. 310 patients who had undergone esophagectomy for cancer in curative intent between 2012 2020 University Medical...
Esophageal cancer is the eighth most common worldwide, with poor prognosis and high mortality. The combination of surgery systemic therapy provide best chances for long-term survival. purpose this study was to analyze impact FLOT protocol on overall survival patients following esophageal adenocarcinoma, a focus who did not benefit in terms pathological remission from neoadjuvant therapy. A retrospective analysis all underwent esophagectomies 2012 2017 locally advanced adenocarcinomas...
Concomitant liver cirrhosis is a crucial risk factor for major surgeries. However, only few data are available concerning cirrhotic patients requiring esophagectomy malignant disease.From prospectively maintained database of esophageal cancer patients, who underwent curative between 01/2012 and 01/2016, with concomitant (liver-cirrhotic LCP) were compared to non-liver-cirrhotic (NLCP).Of 170 14 predominately low MELD scores (≤ 9, 64.3%) identified. Perioperative outcome was significantly...
Despite advances in perioperative management, the 5-year survival rate of patients with esophageal adenocarcinoma (Barrett's cancer) is poor. Adjuvant immunotherapies are currently subject clinical trials. The prognostic role tumor-infiltrating T-lymphocytes (TILs) expressing CD45 has only been investigated primary tumors. significance TILs target organs distant metastases, particular liver, unclear. This study examined influence CD45-positive cells liver parenchyma and tumors on cumulative...
Abstract Pleural empyema is a serious condition leading to significant burden on health care systems due protracted hospitalisations. Treatment ranges from non-surgical interventions such as antibiotic therapy and chest tube placement thoracoscopic or open surgery. Various risk factors which impact outcomes have been investigated. The RAPID (renal, age, purulence, infection source, dietary factors) score clinical identifies patients at of death may be used formulate individual treatment...
Introduction: Autosomal recessive polycystic kidney disease (ARPKD) is the most common ciliopathy in children. It caused by mutations PKHD1 gene, which encodes for fibrocystin/polyductin and leads to remodelling of kidneys liver. The latter may result progressive liver fibrosis with portal hypertension requiring transplantation (CLKT). Currently, there no consensus as indication CLKT data on long-term outcome are scarce. Methods: We analyzed detail pre-transplant symptomatology, laboratory...
Abstract Background Thymic epithelial tumors are rare neoplasias. There no internationally accepted standards to treat this complex oncological disease. The studies on which our knowledge is based frequently have methodological weaknesses. If the tumor resectable, complete surgical excision currently first-line therapy. respond radiation. therapeutic benefit of adjuvant radiotherapy depends stage. To validate and improve treatment, we share current experiences with clinical management...