A5061089265- Photosynthetic Processes and Mechanisms
- Neuroscience and Neuropharmacology Research
- Light effects on plants
- Hungarian Social, Economic and Educational Studies
- Algal biology and biofuel production
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Plant Molecular Biology Research
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Cell death mechanisms and regulation
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Phagocytosis and Immune Regulation
- Polar Research and Ecology
- Gastrointestinal motility and disorders
Budapest University of Economics and Business
2021-2024
Hungarian Academy of Sciences
2004-2023
HUN-REN Institute of Experimental Medicine
2008-2023
MRC Laboratory of Molecular Biology
2009-2014
Agricultural Biotechnology Institute
2006-2008
Institute of Plant Biology
1997-2006
University of Freiburg
2004
HUN-REN Szegedi Biológiai Kutatóközpont
1998-2000
The light environment is a key factor that governs multitude of developmental processes during the entire life cycle plants. An important and increasing part incident sunlight encompasses segment UV-B region (280–320 nm) not entirely absorbed by ozone layer in stratosphere earth. This portion solar radiation, which inevitably reaches sessile plants, can act both as an environmental stress informational signal. To identify Arabidopsis genes involved UV response, we monitored gene expression...
Abstract CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) is a negative regulator of photomorphogenesis in Arabidopsis thaliana. COP1 functions as an E3 ubiquitin ligase, targeting select proteins for proteasomal degradation plants well mammals. Among its substrates the basic domain/leucine zipper (bZIP) transcription factor ELONGATED HYPOCOTYL5 (HY5), one key regulators under all light qualities, including UV-B responses required tolerance to this environmental threat. Here, we report that, contrast...
Sharp wave-ripples and interictal events are physiological pathological forms of transient high activity in the hippocampus with similar features.Sharp have been shown to be essential memory consolidation, whereas epileptiform (interictal) thought damaging.It is grasp difference between sharp understand failure control mechanisms latter case.We investigated dynamics generated intrinsically Cornu Ammonis region 3 mouse vitro, using four different types intervention induce activity.As a...
In this study the role of P2Y12 receptors (P2Y12R) was explored in rodent models inflammatory and neuropathic pain acute thermal nociception. correlation with their activity to block recombinant human P2Y12R, majority P2Y12R antagonists alleviated mechanical hyperalgesia dose-dependently, following intraplantar CFA injection, after partial ligation sciatic nerve rats. They also caused an increase nociceptive threshold hot plate test. Among six evaluated studies, selective receptor antagonist...
GABAergic neurons are key circuit elements in cortical networks. Despite growing evidence showing that inhibitory cells play a critical role the lateral (LA) and basal (BA) amygdala functions, neither number of nor ratio their distinct types has been determined these amygdalar nuclei. Using unbiased stereology, we found BA (22%) is significantly higher than LA (16%) both male female mice. No difference was observed between right left hemispheres either sex. In addition, assessed major cell...
The study seeks to answer the question of what strategic directions and opportunities we have for business in midst info-communication changes our time. In this research, compare results non-representative primary research (cluster analysis discriminant analysis) with factors latest methods e-commerce or even mobile commerce traditional their main differences. Based on four clusters examined, develop a new model practice suggestions which can be used by small medium-sized enterprises (SMEs)...
UV-B irradiation of intactSynechocystis sp. PCC 6803 cells results in the loss photosystem II activity, which can be repaired via de novosynthesis D1 (and D2) reaction center subunits. In this study, we investigated effect on transcription psbA2 and psbA3 genes encoding identical proteins. We show that increases level ofpsbA2 mRNA 2–3-fold and, more dramatically, it induces a 20–30-fold increase accumulation psbA3mRNA even at levels too low to produce losses either activity or protein. The...
Abstract The release of GABA from cholecystokinin-containing interneurons is modulated by type-1 cannabinoid receptors (CB 1 ). Here we tested the hypothesis that strength CB -mediated modulation related to content axon terminals. Basket cell boutons have on average 78% higher than those dendritic-layer-innervating (DLI) cells, a consequence larger bouton surface and density. antagonist AM251 caused 54% increase in action potential-evoked [Ca 2+ ] basket but not DLI cells. However, effect...
Stress-induced cortical alertness is maintained by a heightened excitability of noradrenergic neurons innervating, notably, the prefrontal cortex. However, neither signaling axis linking hypothalamic activation to delayed and lasting nor molecular cascade gating noradrenaline synthesis defined. Here, we show that corticotropin-releasing hormone-releasing innervate ependymal cells 3rd ventricle induce ciliary neurotrophic factor (CNTF) release for transport through brain's aqueductal system....
Necroptosis is a regulated necrotic-like cell death modality which has come into the focus of attention since it known to contribute pathogenesis many inflammatory and degenerative diseases as well tumor regulation. Based on current data, necroptosis serves backup mechanism when receptor-induced apoptosis inhibited or absent. However, necroptotic role proteins involved in mitochondrial not been investigated. Here, we demonstrated that stimulation several pattern recognition receptors induced...
Summary Ultraviolet‐B light (UV‐B) regulates the expression of genes in a wavelength‐ and fluence rate‐dependent fashion. A signaling pathway consisting CONSTITUTIVE PHOTOMORPHOGENESIS 1 (COP1) UV RESISTANCE LOCUS 8 (UVR 8) mediates responsiveness to longer wavelength, low intensity UV‐B light‐activating, for example, HY5 gene expression. By contrast, transcription another group genes, including ANAC13 , modulated by shorter higher is controlled yet unknown largely COP1‐independent cascade....
Gamma-amminobutyric acid (GABA), the major inhibitory neurotransmitter in central nervous system of vertebrates, serves as an autocrine/paracrine signaling molecule during development, modulating a number calcium (Ca(2+))-dependent processes, including proliferation, migration, and differentiation, acting via 2 types GABA receptors (GABARs): ionotropic GABA(A)Rs metabotropic GABA(B)Rs. Here, we demonstrate that mouse embryonic stem cells (mESCs), which possess capacity for virtually...
A subpopulation of GABAergic cells in cortical structures expresses CB1 cannabinoid receptors (CB1 ) on their axon terminals. To understand the function these interneurons information processing, it is necessary to uncover how they are embedded into neuronal circuits. Therefore, proportion terminals expressing and morphological electrophysiological properties -immunoreactive should be revealed. We investigated ratio origin -expressing inhibitory boutons CA3 region hippocampus. Using...
Based on the type-I cannabinoid receptor (CB1) content of hypophysiotropic axons and involvement tanycytes in regulation hypothalamic-pituitary-thyroid (HPT) axis, we hypothesized that endocannabinoids are involved tanycyte-induced TRH release median eminence (ME). We demonstrated CB1-immunoreactive were associated to DAGLα-immunoreactive tanycyte processes external zone ME showed tonically inhibit this tissue. glutamate depolarizes tanycytes, increases their intracellular Ca2+ level 2-AG...
Although extensively studied postnatally, the functional differentiation of cholecystokinin (CCK)-containing interneurons en route towards cerebral cortex during fetal development is incompletely understood. Here, we used CCKBAC/DsRed mice encoding a CCK promoter-driven red fluorescent protein to analyze temporal dynamics DsRed expression, neuronal identity, and positioning through high-resolution developmental neuroanatomy. Additionally, developed dual reporter mouse line...
UV‐B irradiation of Synechocystis 6803 cells inhibits photosystem II activity, which can be restored via de novo synthesis the D1 (and D2) reaction center subunits. Recently we have shown that two psbA genes encode identical proteins in 6803, preferentially enhances transcription psbA3 compared to psbA2 [Máté, Z., Sass, L., Szekeres, M., Vass, I. and Nagy, F. (1998) J. Biol. Chem. 273 , 17439–17444]. Here studied effect on protein from P7 mutant 6803. In this mutant, carries Ala251→Val point...
Calcium-binding proteins are widely used to distinguish neuronal subsets in the brain. This study focuses on secretagogin, an EF-hand calcium sensor, identify distinct populations brainstem of several vertebrate species. By using neural tube whole mounts mouse embryos, we show that secretagogin is already expressed during early ontogeny noradrenaline cells. In adults, secretagogin-expressing neurons typically populate relay centres special senses and vegetative regulatory medulla oblongata,...
In this paper, we present an additional, new cage-GABA compound, called 4-amino-1-(4′-dimethylaminoisopropoxy-5′,7′-dinitro-2′,3′-dihydro-indol-1-yl)-1-oxobutane-γ-aminobutyric acid (iDMPO-DNI-GABA), and currently, compound is the only photoreagent, which can be applied for GABA uncaging without experimental compromises. By a systematic theoretical design successful synthesis of several compounds, best reagent exhibits high two-photon efficiency within 700–760 nm range with excellent...