A5010254910- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Protein Tyrosine Phosphatases
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Liver physiology and pathology
- Microscopic Colitis
- Immunotherapy and Immune Responses
- HIV, Drug Use, Sexual Risk
- Genetic and Kidney Cyst Diseases
- Alkaline Phosphatase Research Studies
- Neutropenia and Cancer Infections
- Gallbladder and Bile Duct Disorders
University Hospital Cologne
2025
University of Cologne
2008-2025
Jena University Hospital
2017
Essen BioScience (United States)
2016
Hanover College
2016
Universitätsklinikum Aachen
2008-2012
University of Kentucky
2005-2010
Albert B. Chandler Hospital
2010
Lexington VA Health Care System
2006
Alcoholic liver disease (ALD) is a common indication for transplantation worldwide. This study identifies factors predicting posttransplant recidivism.Clinical and laboratory data were reviewed. Uni- multivariate analyses survival relapse to alcohol illicit drugs performed.Between July 1995 November 2007, 387 patients underwent at our institution. Of these, 147 (38%) found have ALD. Five (3.4%) excluded because of perioperative mortality. Overall was 96.2%, 89.6%, 84.4% 1, 3, 5 years,...
Abstract Immune memory plays a critical role in the development of durable antimicrobial immune responses. How precisely mRNA vaccines train innate cells to shape protective host defense mechanisms remains unknown. Here we show that SARS-CoV-2 vaccination significantly establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters human monocyte-derived macrophages, suggesting epigenetic memory. However, found two consecutive vaccinations were required for persistence H3K27ac, which...
The integrated project COSYCONET, as part of the competence network ASCONET funded by BMBF, has aim to investigate relationship between pulmonary disorder, comorbidities and systemic inflammation in patients with chronic obstructive disease (COPD) adopting cross-sectional well longitudinal analyses.COSYCONET includes a number projects addressing issue at basic science level. Its core project, however, is establishment cohort COPD, which compared two population-based control cohorts. COPD...
Objectives. We identified correlates of exposure to hepatitis B and C viruses among health department clients in Appalachian Kentucky, a rural region noted for high poverty low education. Additionally, we investigated risk factors transmission, the frequency use preventive measures. Methods. Patients screened or at four county departments Kentucky were administered routine prescreening questionnaire an additional survey designed obtain detailed personal behavioral factor data. These data...
Introduction Early treatment of acute hepatitis C virus (HCV) infection with interferon alfa monotherapy is highly effective but associated frequent unfavorable side effects. There no fully published study yet exploring the safety, efficacy and required duration interferon-free monoinfection. Preliminary reports suggested that ledipasvir/sofosbuvir therapy in relapses were reported HIV-coinfected patients after 6 weeks treatment. Aims & Methods The German HepNet Acute HCV IV Study was...
Hintergrund und Zielsetzung: Es existieren mehrere Erkrankungen mit Manifestation im Dünndarm, die durch eine Duodenalbiopsie gesichert werden können. In dieser Studie sollte Wertigkeit der routinemäßigen tiefen Rahmen Ösophago-Gastro-Duodenoskopie (ÖGD) evaluiert werden. Methodik: Bei 1000 Patienten in einem mittleren Alter von 54,1 Jahren wurden Duodenalbiopsien einer Routineendoskopie entnommen histologisch untersucht. Die dadurch ermittelte Diagnose wurde dem endoskopischen Befund,...
Hintergrund: Inflammatorische Prozesse sind entscheidende Progressionsfaktoren chronischer Lebererkrankungen. Experimentelle Daten legen nahe, dass die Wechselwirkungen zwischen dem Urokinase-Plasminogen-Aktivator (uPA) und seinem Rezeptor (uPAR) Entzündung Fibrose modulieren. Erhöhte Serumkonzentrationen des löslichen Rezeptors (suPAR) spiegeln womöglich Aktivierung Immunsystems wider. Bei kritisch kranken Patienten konnte gezeigt werden, suPAR-Spiegel mit der Mortalität korrelieren.
Purpose: Amyloidosis is a disorder of fibrillary protein deposition in various organ systems and it may be primary (AL) or secondary (AA). Primary amyloidosis can occur alone association with plasma cell dyscrasias such as multiple myeloma. Involvement the liver has been reported up to 70% cases AL amyloidosis. Fulminant failure characterized by rapid development hepatocellular dysfunction encephalopathy patient no prior history disease. We report case fulminant due setting A 66-year-old...
Zigarettenrauchen ist der Hauptrisikofaktor für die Entwicklung einer COPD. COPD Exazerbationen werden durch pathogene Mikroorganismen verursacht und nehmen Einfluss auf den Progress Erkrankung. Ob Therapie COPD-Exazerbation mit dem Gyrasehemmer Moxifloxacin über antibakteriellen Effekt hinaus zudem immunmodulatorische Eigenschaften verfügt, Gegenstand aktueller Forschung. Das Endotoxin des bakteriellen Lipopolysaccharids (LPS) aktiviert spezifisch TLR 4 Signalweg, protektive Immunantworten...
Despite its aggressive nature and high prevalence, there are few case reports on metastatic small cell lung carcinoma resulting in hepatic failure. We present a of fulminant failure that upon autopsy was determined to be secondary carcinoma. A 54 year old male with history coronary artery disease, diabetes mellitus tobacco abuse admitted four-day right upper quadrant abdominal pain anorexia. Exam significant for jaundice tender hepatomegaly. LFTs revealed AST 540 U/L, ALT 525 alkaline...