A5034939548- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Thermodynamics and Molecular Structure
- Organic Chemistry Cycloaddition Reactions
- Synthesis and biological activity
- Molecular spectroscopy and chirality
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Cancer Treatment and Pharmacology
- Computational Drug Discovery Methods
- Chemical Reactions and Mechanisms
- Free Radicals and Antioxidants
- History and advancements in chemistry
- Various Chemistry Research Topics
- Synthesis of β-Lactam Compounds
- Chemical synthesis and alkaloids
- Fluorine in Organic Chemistry
- Eicosanoids and Hypertension Pharmacology
- Chemical synthesis and pharmacological studies
- Chemistry and Chemical Engineering
- Enzyme Catalysis and Immobilization
- Circular RNAs in diseases
Fondazione IRCCS Istituto Nazionale dei Tumori
2024-2025
University of Milano-Bicocca
2023
University of Milan
1987-1992
PHARM (Italy)
1980
University of Pavia
1959-1968
University of Oxford
1959
Istituto Superiore di Sanità
1950
University of Bologna
1939
Munich University of Applied Sciences
1933
Well-differentiated/dedifferentiated liposarcomas (WD/DDLPSs) account for ∼60% of all liposarcomas. They have a poor prognosis due to limited therapeutic options. WD/DDLPSs are characterized by aberrant expression mouse double minute 2 (MDM2), which forms G-quadruplexes (G4s) in its promoter. Here, we investigated the possibility targeting with small molecules against MDM2 G4s. Among tested, naphthalene diimide derivative QN-302 significantly impaired WD/DDLPS cell growth and activity...
Ovarian carcinoma has still a poor prognosis. CRISPR/Cas9 loss-of-function screen revealed relationship between the PSMC6 proteasome subunit expression and survival of cisplatin-sensitive -resistant ovarian cells. Increased levels were evidenced in multiple cell lines versus normal An association tumour stages as well with reduced progression-free was found. Since interactome analysis limited knowledge on biology, mechanistic studies carried out. knockdown indicated growth clonogenicity...
Abstract Deubiquitinases (DUBs) including the proteasome-associated USP14 have emerged as drug targets in cancer and may contribute to resistance. Since DUBs are deregulated ovarian carcinoma, disease management benefit from novel inhibitor development. The aim of this study was identify inhibitors (USP14i) test preclinical models. Cellular pharmacology approaches were employed examine role cisplatin-sensitive resistant cells. An assay for compound screening, previously developed by Lee...
P. Pratesi, A. La Manna, Campiglio and V. Ghislandi, J. Chem. Soc., 1958, 2069 DOI: 10.1039/JR9580002069
P. Pratesi, A. La Manna, Campiglio and V. Ghislandi, J. Chem. Soc., 1959, 4062 DOI: 10.1039/JR9590004062
The segmentation of patients into homogeneous groups could help to improve eradication therapy effectiveness. Our aim was determine the most important treatment strategies used in Europe, evaluate first-line effectiveness according year and country. Data collection: All empirical treatments registered at AEGREDCap European Registry on Helicobacter pylori management (Hp-EuReg) from June 2013 November 2022. A Boruta method determined “most important” variables related clustering performed...
A number of optically active amines have been tested as substrates or inhibitors amine oxidase rabbit and guinea‐pig liver. The two stereoisomers β‐hydroxyphenethylamine were oxidized at the same rate by liver, but liver extracts d form more rapidly than l form. amphetamine equally oxidase, with dexamphetamine, (+) form, was potent an inhibitor. In both species, 2‐hydroxy‐1‐phenylethylamine a weaker inhibitor 1‐phenylethylamine; in forms these inhibitors.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Possible Correlation between Configuration of Optically Active Bases and Velocity Decarboxylation Dextro- Levo-Camphocarboxylic Acids in their Presence1P. Pratesi, L. Arpesella, A. La MannáCite this: J. Am. Chem. Soc. 1953, 75, 22, 5476–5478Publication Date (Print):November 1, 1953Publication History Published online1 May 2002Published inissue 1 November 1953https://doi.org/10.1021/ja01118a002RIGHTS & PERMISSIONSArticle...
Abstract Ovarian carcinoma is a disease with poor prognosis, due to delays in diagnosis and the development of drug resistance. Since deregulation ubiquitin proteasome system may contribute resistance, aim this study was investigate interplay between expression subunits cisplatin resistance by utilizing CRISPR/Cas9 dropout screen. Paired cisplatin-sensitive -resistant cells (IGROV-1 IGROV-1/Pt1) were transfected Cas9 transduced gRNAs against components. Cells collected at early (day 4) late...
The two enantiomers and the racemic form of bethanechol have been synthesized their muscarinic activities evaluated on isolated rat jejunum. stereoselectivity observed for parallels that previously reported acetyl-beta-methylcholine muscarine same biological object.
Abstract This report examines the development of quantitative structure‐activity relationships (QSAR) in analysis ligand muscarinic receptor interactions. Several sets agonists acting on different tissues (distinct subtypes) are considered. It is shown that QSAR may represent a suitable tool to increase general understanding nature interactions at sites. The points discussed paper draw attention correlations between biological affinity constants and molecular architecture ligands which...
Abstract Several sets of ligands acting as antagonists at muscarinic receptor sites are considered by means QSAR approach. Although the confusing role collinearity among vectors associated with physicochemical parameters makes it sometimes difficult to evaluate quality structure‐activity correlations, points discussed in paper draw attention development correlations between biological affinity constants and structural features antagonists. The results obtained compared those relative an...