A5103383409- Hematopoietic Stem Cell Transplantation
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Immune Cell Function and Interaction
- Pain Mechanisms and Treatments
- Childhood Cancer Survivors' Quality of Life
- Antibiotic Resistance in Bacteria
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- Bioactive Natural Diterpenoids Research
- Bacterial biofilms and quorum sensing
- Epigenetics and DNA Methylation
- Intensive Care Unit Cognitive Disorders
- Neuropeptides and Animal Physiology
- Cervical and Thoracic Myelopathy
- Neonatal Respiratory Health Research
- Quinazolinone synthesis and applications
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Plant-derived Lignans Synthesis and Bioactivity
- Optical Imaging and Spectroscopy Techniques
- Immunodeficiency and Autoimmune Disorders
Universitätsmedizin Göttingen
2025
Sendai Medical Center
2024
National Hospital Organization
2024
Tohoku University
2024
Nanchang University
2022-2024
Xuzhou Medical College
2023
Chinese PLA General Hospital
2023
First Affiliated Hospital of Nanchang University
2022-2023
Sun Yat-sen University
2022
The First Affiliated Hospital, Sun Yat-sen University
2022
BackgroundPostoperative delirium (POD) is a common and severe postoperative complication in elderly patients undergoing major surgery linked to increased morbidity mortality. It reported that transcranial direct current stimulation (tDCS) effectively enhances cognitive function improves impaired consciousness.ObjectiveThis study aimed evaluate the efficacy of tDCS on POD lower limb arthroplasty, including total hip arthroplasty (THA) or knee (TKA).MethodsPatients aged ≥65 years scheduled for...
Abstract Background Epigenetic regulations play pivotal roles in tumorigenesis and cancer development. Disruptor of telomeric silencing-1-like (DOT1L), also known as KMT4, is the only identified histone methyltransferase that catalyzes mono-, di-, tri-methylation lysine 79 3 (H3K79). However, little about effect H3K79 methylation on modulation colorectal (CRC) Methods DOT1L expression profiles different subgroups CRC tissues its clinical significances were analyzed from some online...
Abstract Recently, many researches have reported that antibiotic tigecycline has significant effect on cancer treatment. However, biomedical functions and molecular mechanisms of in human pancreatic ductal adenocarcinoma (PDAC) remain unclear. In the current study, we tried to assess PDAC cells. AsPC‐1 HPAC cells were treated with indicated concentrations for time, then, MTT, BrdU soft agar assay used test cell proliferation. The cycle cellular apoptosis was tested by cytometry. Migration...
Pedicle screw fixation using the cortical bone trajectory (CBT) enhances stability by engaging bone, offering a valuable alternative to traditional pedicle (TT). This study used finite element analysis compare L4-5 instrumentation with CBT and TT screws, investigating whether increased engagement in improves but makes it more susceptible fatigue failure. A L3-sacrum model was generated anonymized CT patient data, validated against existing studies, showing consistent ROM (range of motion)...
Femoral neck fractures are prevalent in orthopedic injuries, often leading to complications such as nonunion and osteonecrosis of the femoral head (ONFH). Studies indicate that after healing removal internal fixation devices, some patients develop ONFH, while others experience osteosclerosis around screw holes due prolonged fixation, increasing ONFH risk. Despite observations, biomechanical studies on this phenomenon limited. This study assesses risk collapse post-internal device...
Fatigue is one of the most common and distressing symptoms experienced by adolescents during after treatment for cancer. The lack reliable valid instruments has prevented an accurate assessment trajectory fatigue among adolescent oncology patients. purposes this study were to identify items on Scale–Adolescent (FS-A) that distinguished with high sensitive specific score (“cut score”) in order those need a intervention. Rasch methods used FS-A cancer-related fatigue, results indicated 14-item...
Summary The long‐term antibody responses to re‐immunization in recipients of allogeneic haematopoietic stem cell transplantation (allo‐HSCT) have not been well studied. We prospectively and longitudinally evaluated the eight vaccine antigens (diphtheria, tetanus, pertussis, measles, mumps, rubella, hepatitis B, poliovirus) assessed factors associated with negative titres 210 allo‐HSCT at St. Jude Children’s Research Hospital. Antibody lasting for more than 5 years after immunization were...
The aim of the study was to investigate possibility human umbilical cord mesenchymal stem cells (UC-MSCs) surviving and differentiating into hepatocyte-like in partially hepatectomized model rats. MSCs were isolated from cultured with collagenase digestion. Cell surface markers detected fifth generation UC-MSCs labeled PKH26. rats injected transplanted through portal vein. survival cells, differentiation conditions expression hepatic marker albumin observed at post-transplantation 1, 2 3...
Abstract Human parainfluenza viruses (hPIVs) are causative agents of upper and lower respiratory tract infections they have four serotypes. The virion surface displays hemagglutinin‐neuraminidase (HN), having hemagglutinating (HA) neuraminidase (NA) activities in a single molecule. HA activity binds the to sialic acid on viral receptor host cells NA releases progeny from cell surface. There several methods for assaying activity, such as thiobarbituric assay, 4‐methylumbelliferyl‐ N...
Pillai A, Hartford C, Wang Pei D, Yang J, Srinivasan Triplett B, Dallas M, Leung W. Favorable preliminary results using TLI/ATG‐based immunomodulatory conditioning for matched unrelated donor allogeneic hematopoietic stem cell transplantation in pediatric severe aplastic anemia. Pediatr Transplantation 2011: 15: 628–634. © 2011 John Wiley & Sons A/S. Abstract: To assess whether a tolerance‐induction regimen could be applied (MUD) HCT SAA, we retrospectively reviewed our experience...
We have explored the concept of a molecular extender arm attached to κ opioid agonist pharmacophore 3 (ICI-199,441) in an effort potentially interact with complementary group on neighboring receptor. The containing terminal amine was lengthened incrementally from 11 up 18 atoms. Increasing number atoms produced virtually no change mouse intracerebroventricular (i.c.v.) antinociceptive potency. In contrast, intrathecal (i.t.) potency 6 (KDA-16) 16-atom dramatically increased, as reflected by...
This study analyzes the hematopoietic cell transplantation experience in patients with immune deficiency at a single institution. The objective is to comprehensively evaluate short-term and long-term outcomes various preparative regimens, donor grafts, ex vivo manipulations identify approaches that most likely favor early competency without generating excessive toxicity. Clinical were evaluated 52 consecutive deficiencies. Thirty-seven of (71%) survived attenuation their underlying disease....
Blood-brain barrier (BBB) is the most important component of central nervous system (CNS) to keep toxins and pathogens from CNS. Although our studies demonstrated that using interleukin-6 antibodies (IL-6-AB) reversed increased permeability BBB, IL-6-AB limited in their application only could be used a few hours before surgery seemed delayed surgical wounds healing process, which urges us find another more effective method. In this study, we employed C57BL/6J female mice investigate...
Yang, Jie; Zhou, Yongfan; Kang, Yan; Xu, Binbin; Wang, Peng; Lv, Yinxia; Zhen Author Information
Four new neolignans (<bold>1–4</bold>) were isolated from the seeds of <italic>Daphniphyllum macropodum</italic> Miq. and evaluated for their antiproliferative activity showed that <bold>2</bold> could induced apoptosis in A549 cells through activating mitochondrial pathway.
This study examined cervical center of rotation (COR) positions in seven postures using validated cone beam computed tomography (CBCT) combined with 3D-3D registration healthy volunteers. CBCT scans were performed on twenty volunteers functional positions, constructing a three-dimensional model. Images registered to the neutral position registration, allowing analysis kinematic differences and rotational axes. COR measurements obtained for each segment (C2/3 C6/7) posture. The CORs C2/3 C6/7...
Hepatocellular carcinoma is one of the most prevalent malignancies and a leading cause cancer-related mortality worldwide. However, therapies to prevent hepatocellular are still limited emergence drug resistance leads development new anti-cancer drugs combinational chemotherapy regimens. Our study was aimed explore anticancer effects essential oil extract (EEEO) from Euphorbia esula which has been widely used in traditional Chinese folk medicine possessed potential cytotoxic several human...