A5047739742- Nerve injury and regeneration
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Pain Mechanisms and Treatments
- Lipid Membrane Structure and Behavior
- Adolescent and Pediatric Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Axon Guidance and Neuronal Signaling
- Tissue Engineering and Regenerative Medicine
- Ear and Head Tumors
- Bacterial Genetics and Biotechnology
- Exercise and Physiological Responses
- Pregnancy and Medication Impact
- Neurogenetic and Muscular Disorders Research
- Bacteriophages and microbial interactions
- Anesthesia and Neurotoxicity Research
- Facial Nerve Paralysis Treatment and Research
- Renal Diseases and Glomerulopathies
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Microbial Fuel Cells and Bioremediation
- Adenosine and Purinergic Signaling
- RNA and protein synthesis mechanisms
University of Wisconsin–Madison
2024
University of Michigan
2016-2023
University of Miami
2021
Triological Society
2020
Michigan Medicine
2020
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Northwestern University
2016
The spinal cord is unable to regenerate after injury largely due growth-inhibition by an inflammatory response the that fails resolve, resulting in secondary damage and cell death. An approach prevents inhibition attenuating promoting its resolution through transition of macrophages anti-inflammatory phenotypes essential for creation a growth permissive microenvironment. Viral gene delivery induce expression factors provides potential provide localized alter host response. Initially, we...
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an has constituted a difficult clinical challenge. The complex, dynamic, inhibitory microenvironment postinjury, which is characterized by proinflammatory signaling from invading leukocytes lack sufficient factors that promote axonal survival elongation, limits regeneration. Herein, we investigated delivery polycistronic vectors, potential to coexpress target distinct barriers...
A complex cellular cascade characterizes the pathophysiological response following spinal cord injury (SCI) limiting regeneration. Biomaterial and stem cell combination therapies together have shown synergistic effects, compared to independent benefits of each intervention, represent a promising approach towards regaining function after injury. In this study, we combine our polyethylene glycol (PEG) delivery platform with lentiviral-mediated overexpression anti-inflammatory cytokine...
An important role of neural stem cell transplantation is repopulating and glial cells that actively promote repair following spinal cord injury (SCI). However, survival after severely hampered by the inflammatory environment arises SCI. Biomaterials have a demonstrated history managing post-SCI inflammation can serve as vehicle for delivery. In this study, we utilize macroporous polyethylene glycol (PEG) tubes, which were previously found to modulate microenvironment, viable, soft substrate...
Abstract Spinal cord injury (SCI) results in paralysis below the and strategies are being developed that support axonal regrowth, yet recovery lags, part, because many axons not remyelinated. Herein, we investigated to increase myelination of regenerating by overexpression platelet‐derived growth factor (PDGF)‐AA noggin either alone or combination a mouse SCI model. Noggin PDGF‐AA have been identified as factors enhance recruitment differentiation endogenous progenitors promote myelination....
Abstract Neuropathic pain is a critical source of comorbidity following spinal cord injury (SCI) that can be exacerbated by immune-mediated pathologies in the central and peripheral nervous systems. In this article, we investigate whether drug-free, biodegradable, poly(lactide- co -glycolide) (PLG) nanoparticle treatment mitigates development post-SCI neuropathic female mice. Our results show acute with PLG nanoparticles thoracic SCI significantly reduces tactile cold hypersensitivity scores...
Spinal cord injury (SCI) causes permanent paralysis below the damaged area. SCI is linked to neuronal death, demyelination, and limited ability of fibers regenerate. Regeneration capacity by presence many inhibitory factors in spinal environment. The use poly(lactide-co-glycolide) (PLG) bridges has demonstrated sustain long-term regeneration after a cervical hemisection mouse model. Critically, imaging regenerating myelination status these filaments severe limitation progress research. We...
Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and bladder, bowel, sexual function. Patients are rarely treated immediately, this delay associated with tissue scar formation can make regeneration at chronic time points more challenging. Herein, we investigated using poly(lactide-co-glycolide) multichannel bridge implanted into SCI following surgical resection necrotic tissue. We characterized dynamic...
Many bacteria build elaborate molecular machines to import DNA via natural competence, yet this activity is often not identified until strains have been handled and domesticated in laboratory settings. For example, one of the best studied Gram-positive model organisms, Bacillus subtilis, has a non-transformable ancestor. Transformation ancestral strain inhibited by transmembrane peptide, ComI, which encoded on an extrachromosomal plasmid. Although ComI was shown be necessary sufficient...
ABSTRACT Many bacteria build elaborate molecular machines to import DNA via natural competence, yet this activity is often not identified until strains have been handled and domesticated in laboratory settings. For example, one of the best studied Gram-positive model organisms, Bacillus subtilis, has a poorly transformable ancestor. Transformation ancestral strain inhibited by transmembrane peptide, ComI, which encoded on an extrachromosomal plasmid. Although ComI was shown be necessary...
US$18141 (US and Rest of World), € 11707 (Europe), £ 9260 (UK
Objectives/Hypothesis Facial nerve injury is a source of major morbidity. This study investigated the neuroregenerative effects inducing an anti‐inflammatory environment when reconstructing facial defect with multichannel bridge containing interleukin‐4 (IL‐4)–encoding lentivirus. Study Design Animal study. Methods Eighteen adult Sprague‐Dawley rats were divided into three groups, all which sustained gap defect. Group I had reconstruction performed via IL‐4 bridge, group II saline placed,...
Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term complications, leading to high healthcare costs reduced quality of life for patients. The majority relapses are triggered by upper respiratory tract infections (URTIs) evidence shows that daily low-dose prednisolone at the time infection may reduce risk relapse.The aim this study was assess cost effectiveness 6-day course start URTI when compared placebo.A state-transition...
The pathophysiological response following spinal cord injury (SCI) is characterized by a complex cellular cascade that limits regeneration. Biomaterial and stem cell combination therapies have shown synergistic effects, compared to their interventions independent of each other, represent promising approach towards regaining function after injury. In this study, we combine our polyethylene glycol (PEG) delivery platform with lentiviral-mediated overexpression the anti-inflammatory cytokine...