A5008023825- Gastric Cancer Management and Outcomes
- Cancer and Skin Lesions
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Genetic and rare skin diseases.
- Colorectal Cancer Surgical Treatments
- Renal Transplantation Outcomes and Treatments
- Corneal Surgery and Treatments
- Renal Diseases and Glomerulopathies
- Vascular Tumors and Angiosarcomas
- Hedgehog Signaling Pathway Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Soft tissue tumors and treatment
- Inflammatory mediators and NSAID effects
- Endometrial and Cervical Cancer Treatments
- Retinoids in leukemia and cellular processes
- Ocular Diseases and Behçet’s Syndrome
- Colorectal Cancer Treatments and Studies
- Neurofibromatosis and Schwannoma Cases
- Colorectal and Anal Carcinomas
- Ocular Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Oral and Maxillofacial Pathology
Inje University Busan Paik Hospital
2015-2024
Inje University
2007-2021
Samsung Medical Center
2014
Sungkyunkwan University
2014
Dong-A University Hospital
2012
Inje University Sanggye Paik Hospital
2001
As a result of various independently proposed nomenclatures and classifications, there is confusion in the diagnosis prediction biological behavior gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A comprehensive nationwide study needed order to understand characteristics GEP-NETs Korea.We collected 4,951 pathology reports from 29 hospitals Korea between 2000 2009. Kaplan-Meier survival analysis was used determine prognostic significance clinicopathological parameters.Although...
Multiple gastrointestinal stromal tumors (GISTs) are extremely rare and usually associated with type 1 neurofibromatosis familial GIST. The aim of this study was to investigate the clinical, phenotypic, genetic characteristics multiple GISTs gain insights into their underlying pathogenesis clinical behavior. Forty-seven paraffin blocks from 12 patients were analyzed. Genomic DNA extracted tumor normal mucosa mutations for 4 exons KIT gene 3 PDGFRA determined. Among GISTs, 5 sporadic, 2...
The protein V-set and Ig domain-containing 4 (VSIG4), a novel B7 family-related macrophage with the capacity to inhibit T-cell activation, has potential role in cancer. Here we suggest its possibility as therapeutic target prognostic biomarker of ovarian cancer.Between January 2011 June 2015, tumor tissues peripheral blood samples were obtained during surgery from 10 patients benign tumors 22 cancers. Messenger RNA expression levels VSIG4 cancer examined by reverse transcription polymerase...
Discrepancies in the clinicopathologic parameters pre- and post-endoscopic submucosal dissection (ESD) sometimes necessitate additional surgical resection. The aim of this study was to assess such discrepancies before after ESD context reducing risk failure curative ESD.Data on 712 early gastric cancer patients were prospectively collected from 12 university hospitals nationwide. inclusion criteria differentiated carcinoma <3 cm size, no ulceration, invasion <500 μm, metastasis....
Background: Despite the widespread impact of severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) and vaccination in South Korea, our understanding kidney diseases following these events remains limited. We aimed to address this gap by investigating characteristics glomerular COVID-19 infection Korea. Methods: Data from multiple centers were used identify de novo glomerulonephritis (GN) cases with suspected onset or vaccination. Retrospective surveys determine...
Background Butyrophilins (BTNs) are immunoglobulin superfamily proteins involved in immune regulation. Among them, BTNL9 has unique structural features, including a bZIP-like domain, suggesting potential transcriptional role. While is known to suppress T cell activation, its function cancer remains largely unexplored. Recent studies suggest it may inhibit tumor progression and correlate with improved prognosis multiple cancers. However, molecular mechanisms regulatory impact on lung remain...
FOLFOX-based adjuvant chemotherapy is a benefit for high-risk stage II and III colon cancer after curative resection. But, the prognostic factor or predictive marker efficacy of FOLFOX remains unclear. This study was aimed to identify value cumulative impact on patients. A total 196 patients were retrospectively enrolled in prospectively collected data. They underwent resection followed by FOLFOX4 chemotherapy. The oncological outcomes included 5-year disease-free survival (DFS) rate overall...
In 2010, the World Health Organization categorized L-cell type neuroendocrine tumors (NETs) as of uncertain malignancy, while all others were classified malignant. However, diagnostic necessity immunophenotyping is unclear, are tumor stage and grade that may guide diagnosis management. To clarify predictive markers rectal neoplasms (NENs), 5- 10-year overall survival (OS) was analyzed by pathological parameters including phenotype.A total 2,385 NENs from our previous multicenter study a...
The aims of this study were to clarify the activation complement pathways in patients with lupus nephritis (LN), and elucidate association between these types clinical outcomes.We enrolled 115 biopsy-proven LN from 2003 2016 cohort at Busan Paik Hospital Jeju National University Korea. divided into two groups based on patterns glomerular complements deposits. presence C1q, C4 and/or C3 deposits glomerulus was considered evidence for classical pathway or without alternative (group 1, N = 93),...
This study was conducted to determine the clinicopathologic factors affecting stage of ulcerative early gastric cancer (EGC), focusing on relationships between and degree endoscopic ulcer depth morphologic changes.Medical records 183 cases EGC who had received examination two or more times with a minimum interval one week, underwent either curative surgery treatment were retrospectively reviewed.Change in morphology at follow-up endoscopy observed 84 (45.9%) improvement exacerbation 65...
Purpose The diagnostic criteria of gastric intraepithelial neoplasia (IEN) are controversial across the world. We investigated how many discrepancies occur in pathologic diagnosis IEN and early carcinoma endoscopic submucosal dissection (ESD) specimens, evaluated reasons discordance. Materials Methods retrospectively reviewed 1,202 ESD specimens that were originally diagnosed as at 12 institutions. Results final consensus 756 cases, which 692 carcinomas (91.5%), 43 high-grade dysplasias...
Abstract Objective To describe an instance of complete chorion‐amnion membrane separation with fetal restrictive dermopathy in two consecutive pregnancies. Methods We performed prenatal ultrasounds pregnancies and evaluated gross microscopic postnatal findings. Results The first pregnancy ended at 32 weeks gestation spontaneous chorioamniotic preterm premature rupture membranes. mother delivered abnormal male infant generalized fixed joint contractures, rigid shiny skin, skin laceration...
Gangliocytic paragangliomas (GPs) are rare tumors of the duodenum, presenting as single sessile or pedunculated polypoid masses. Clinical manifestations duodenal GPs can vary from an incidental finding at endoscopy to frequent upper gastrointestinal bleeding caused by mucosal ulceration and abdominal pain. considered benign, but disease recur spread regional lymph nodes. A 41-year-old female presented with Upper revealed a subepithelial tumor ampulla Vater in second portion duodenum. The was...
The aim of this study was to evaluate the validity parameters conventional white-light endoscopy and magnifying with narrow-band imaging (MENBI) for prediction discrepancies between pre- post-resectional histology in cases gastric adenoma low-grade dysplasia (LGD) that were diagnosed based on endoscopically biopsied specimens.The medical records 266 lesions LGD by endoscopic forceps biopsies retrospectively reviewed. Vienna classification used histologic diagnosis. These patients all...
A 50-yr-old male presented a thyroid mass with dysphasia and hoarseness.He underwent total thyroidectomy neck node dissection.Pathologically, the tumor had two distinct components intermingled areas: follicular variant of papillary carcinoma mucoepidermoid carcinoma.Mucoepidermoid composed columnar cells, mucocytes, squamoid cells showing solid cystic lesion.Several small cysts lined by benign ciliated epithelia suggesting that this originated from cell nest were seen around tumor.By...
Extraskeletal Ewing' s Sarcoma of the Hard PalateExtraskeletal Ewing's sarcoma (EES) is a rare soft tissue tumor morphologically indistinguishable from more common bone.We report case EES arising in hard palate 34-yr-old male patient.Microscopically, monotonous small round cells without neuronal differentiation showed membranous positive immunoreactivity for MIC2/CD99 and vimentin.Ultrastructurally, few intracytoplasmic organelles evidence neurosecretory granules or neurofilaments.The...
To observe the changes in protein expression induced by botulinum toxin A (BoNT-A) injection and to characterize molecular cellular action of mechanisms BoNT-A on skeletal muscles using proteomic elements as biomarkers.BoNT-A was injected into left gastrocnemius 12 Sprague-Dawley rats (2 months age) at a dosage 5 units/kg body weight. For controls same volume normal saline right muscle each rat. Muscle samples were obtained 4 time points (3 per point): 3, 7, 14, 56 day post-injection. reveal...
Esophagomediastinal fistula secondary to mediastinal tuberculosis (TB) lymphadenitis is a rare and unusual complication. A 32-year-old woman visited our clinic because of chest pain. Computed tomography (CT) demonstrated an esophagomediastinal with subcarinal lymphadenopathy no remarkable parenchymal lung lesions. The was confirmed by esophagoscopy; however, the patient's bronchoscopy findings were unremarkable. endobronchial ultrasound-guided lymph node aspiration did not confirm diagnosis...