A5100409792- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Synthesis and Properties of Aromatic Compounds
- Gene Regulatory Network Analysis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Regulation of Appetite and Obesity
- Plant tissue culture and regeneration
- Image and Video Quality Assessment
- Angiogenesis and VEGF in Cancer
- Natural Products and Applications
- Gut microbiota and health
- Biomedical Text Mining and Ontologies
- Pericarditis and Cardiac Tamponade
- Diet and metabolism studies
- Renal and related cancers
- Antimicrobial Resistance in Staphylococcus
- Coconut Research and Applications
- Chromatin Remodeling and Cancer
- Tryptophan and brain disorders
- DNA and Biological Computing
- Phagocytosis and Immune Regulation
- Plant Gene Expression Analysis
Fudan University Shanghai Cancer Center
2025
Huazhong University of Science and Technology
2025
Union Hospital
2025
Yanbian University
2024
Peking University Shenzhen Hospital
2024
Second Hospital of Shanxi Medical University
2023
Shanxi Medical University
2023
Suzhou Municipal Hospital
2023
Nanjing Medical University
2023
South China Botanical Garden
2020-2023
Microvesicles known as exosomes have a diameter of 40 to 160 nm and are derived from small endosomal membranes. Exosomes attracted increasing attention over the past ten years in part because they functional vehicles that can deliver variety lipids, proteins, nucleic acids target cells encounter. Because this function, may be used for diagnosis, prognosis treatment many diseases. All throughout world, cardiovascular diseases (CVDs) continue significant cause death. mediators communication...
The synthesis of high-spin polycyclic hydrocarbons is very challenging due to their extremely high reactivity. Herein, we report the and characterization a kinetically blocked 1,14:11,12-dibenzopentacene, DP-Mes, which represents rare persistent triplet diradical non-Kekulé benzenoid hydrocarbon. In contrast its structural isomer 1,14:7,8-dibenzopentacene (heptazethrene) with singlet biradical ground state, DP-Mes as confirmed by ESR ESTN measurements density functional theory calculations....
To elucidate the value of texture analysis (TA) in detecting and differentiating myocardial tissue alterations on T2-weighted CMR (cardiovascular magnetic resonance imaging) patients with cardiac amyloidosis (CA) hypertrophic cardiomyopathy (HCM).In this retrospective study, 100 CA (58.5 ± 10.7 years; 41 (41%) females) 217 HCM (50.7 14.8 years, 101 (46.5%) who underwent scans were included. Regions interest for TA delineated by two radiologists independently imaging (T2WI). Stepwise...
Open AccessCCS ChemistryCOMMUNICATION7 Dec 2022Air Stable Chalcogen-Doped Rubicenes with Diradical Character Liangzhuo Ma†, Song Wang†, Yuan Li†, Qinqin Shi, Wenbin Xie, Hao Chen, Xin Wang, Weiya Zhu, Lang Jiang, Runfeng Qian Peng and Hui Huang Ma† College of Materials Science Opto-Electronic Technology, Center Optoelectronics Engineering, CAS for Excellence in Topological Quantum Computation, Key Laboratory Vacuum Physic, University Chinese Academy Sciences, Beijing 100049 , Wang† Li†...
Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and resistance are believed to cause obesity. The transcription factor Slug — also known as Snai2 recruits epigenetic modifiers regulates gene expression an mechanism; however, action has not been explored in resistance. Here, we uncover a proobesity function of neuronal Slug. Hypothalamic was upregulated obese mice. LepRb+ cell–specific Slug-knockout (SlugΔLepRb) mice were...
ABSTRACT Triple-negative breast cancer (TNBC) represents the most aggressive subtype, which recently attracts great interest for immune therapeutic development. In this context, in-depth understanding of TNBC landscape is highly demanded. Here we report single-cell RNA sequencing results 9683 tumor-infiltrated cells isolated from 14 treatment naïve tumors, where 22 cell subsets, including T cells, macrophages, B and DCs have been characterized. We identify a new subset, CD8 + CXCL8 cell,...
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by the absence of dystrophin. Vascular endothelial growth factor (VEGF) heparin‑binding dimeric glycoprotein and principal angiogenic stimulating migration, proliferation expression various genes in cells. Recently, VEGF was demonstrated to exhibit an antiapoptotic direct myogenic effect, as well enhance muscle force restoration subsequent traumatic injury. Therefore, present study attempted assess damage...
Gut mycobiota play indispensable roles in human health. However, little is known about the alterations to gut and their correlations with coronary heart disease (CHD) Tibetan subjects. We conducted a study based on shotgun metagenomic sequencing of DNA extracted from faecal samples analyse taxonomic composition functional annotation 14 CHD patients, 13 patients non-stenosis (NCHD), 18 healthy controls (HT). The TMAO, creatinine, TG levels group were significantly higher than HT....
In this paper, we obtain complete characterization for nested canalyzing functions (NCFs) by obtaining its unique algebraic normal form (polynomial form). We introduce a new concept, LAYER NUMBER NCF. Based on this, explicit formulas the following important parameters: 1) Number of all functions, 2) NCFs with given NUMBER, 3) Hamming weight any NCF, 4) The activity number variable 5) average sensitivity these formulas, show is greater those variables in out layer and equal same layer....
Abstract Background: As an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression, KDM6B has been implicated in the development malignant progression various types of cancers. However, its potential roles esophageal squamous cell carcinoma (ESCC) have not explored. Methods: The expression human ESCC tissues lines was examined using qRT-PCR, immunohistochemical staining immunoblotting. effects on proliferation metastasis were vitro vivo functional tests. RNA-seq...
Abstract Backgrounds: Paphiopedilum is an important genus of the orchid family Orchidaceae and has high horticultural value. The wild populations are under threat extinction because overcollection habitat destruction . Mature seeds most species difficult to germinate, which severely restricts their germplasm conservation commercial production factors inhibiting germination largely unknown. Results: In this study, large amounts non-methylated lignin accumulated during seed maturation...
Abstract Background PFKP (phosphofructokinase, platelet), a rate-limiting enzyme of glycolysis, plays decisive role in various human physio pathological processes. Multiple function different cancer types was reported, including lung cancer, breast et al. However, systematic pan-cancer analysis has not been performed now, which could reflect its clinically value about diagnosis, prognosis, drug sensitivity, and immunological correlation. Methods Systematic bioinformation based on several...
Abstract BackgroundPeroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that has the potential to be associated with development of colorectal cancer (CRC). However, exact role PPARδ in context CRC remains clarified. This present study was thus designed understand association between risk and PPARδ-87T>C single nucleotide polymorphism (SNP) western Chinese Han population. MethodsThe (rs2016520) analyzed via polymerase chain reaction-restriction fragment...