A5100777837- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Genetic factors in colorectal cancer
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Esophageal and GI Pathology
- Atrial Fibrillation Management and Outcomes
- Colorectal Cancer Screening and Detection
- Cardiac pacing and defibrillation studies
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Acute Ischemic Stroke Management
- Cardiovascular Effects of Exercise
- Helicobacter pylori-related gastroenterology studies
- Clinical Nutrition and Gastroenterology
Hasselt University
2023-2025
Hartcentrum Hasselt
2024-2025
Jessa Hospital
2023-2025
KU Leuven
2019-2024
Universitair Ziekenhuis Leuven
2021-2024
IPO Porto
2015-2023
Centro Cardiologico Monzino
2022
Hospital de São João
2004-2020
Hospital de Santa Cruz
2020
Hospital Center of Cova da Beira
2020
Abstract Aims Myocardial scar detected by cardiovascular magnetic resonance has been associated with sudden cardiac death in dilated cardiomyopathy (DCM). Certain genetic causes of DCM may cause a malignant arrhythmogenic phenotype. The concepts left ventricular (LV) (ALVC) and are currently ill-defined. We hypothesized that distinctive imaging phenotype defines ALVC. Methods results Eighty-nine patients DCM-associated mutations [desmoplakin (DSP) n = 25, filamin C (FLNC) 7, titin 30, lamin...
Background Patients with mitral valve prolapse (MVP) may develop adverse outcomes even in the absence of regurgitation or left ventricular (LV) dysfunction. Purpose To investigate prognostic value annulus disjunction (MAD) and myocardial fibrosis at late gadolinium enhancement (LGE) cardiac MRI patients MVP without moderate-to-severe LV Materials Methods In this longitudinal retrospective study, 118 144 studies were evaluated between October 2007 June 2020 15 European tertiary medical...
Purpose To use unsupervised machine learning to identify phenotypic clusters with increased risk of arrhythmic mitral valve prolapse (MVP). Materials and Methods This retrospective study included patients MVP without hemodynamically significant regurgitation or left ventricular (LV) dysfunction undergoing late gadolinium enhancement (LGE) cardiac MRI between October 2007 June 2020 in 15 European tertiary centers. The end point was a composite sustained tachycardia, (aborted) sudden death,...
Background and objective: Little is known about the clinical impact of double-balloon enteroscopy (DBE) in patients with Peutz-Jeghers syndrome (PJS).The aim this study was to assess efficacy safety DBE management small-bowel polyps PJS patients.Patients methods: We conducted a multicentre, retrospective cohort study, which included all consecutive diagnosed who underwent for polypectomy between January 2006 August 2012.In cases, previous videocapsule had shown at least one polyp ≥ 10 mm...
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Helicobacter pylori (HP) infection. Our aim was to evaluate demographic, clinical and endoscopic characteristics of gastric MALT patients, as well analyse response treatment factors that affect complete remission (CR) relapse. We also assessed the long-term prognosis.The study involved a retrospective evaluation consecutive patients admitted (1993-2013).A total 144 (76 men; mean age 56) were included. At...
Recent guidelines redefined exercise pulmonary hypertension as a mean artery pressure/cardiac output (mPAP/CO) slope >3 mm Hg·L
Abstract Background Exercise-induced pulmonary hypertension, characterized by mean artery pressure over cardiac output slope (mPAP/CO slope) > 3mmHg/L/min is associated with worse outcome in greater than moderate primary mitral regurgitation (PMR). However, the prognostic value of right ventricle to coupling (RVPAc) unknown. Purpose Assess RVPAc; determine additional exercise rest RVPAc and compare these findings mPAP/CO slope. Methods The single center study included consecutive...
Abstract Background Pulmonary artery pressure corrected for cardiac output (mPAP/CO) assessed by exercise echocardiography and calculated as the mPAP/CO slope improves risk stratification in various populations. However, it is unclear whether simplified alternatives have a similar predictive ability outcomes. Purpose To evaluate methodology employed to calculate affects prognostic assessment. Methods This secondary analysis of multicenter cohort study that included patients with unexplained...
Abstract Background According to the Fick equation, oxygen uptake (VO2) equals product of cardiac output (CO) and arteriovenous difference (a-vO2Diff). Cardiopulmonary exercise testing (CPET) provides pulse (O2pulse) as ratio VO2 heart rate. The O2pulse is often considered a surrogate for stroke volume (SV) during effort, ignoring AVO2Diff, assess hemodynamic response exercise. Purpose To compare SV measured independently by simultaneous CPET echocardiography (CPETecho). Methods Observation...
Abstract Background Atrial fibrillation (AF) is a common comorbidity in individuals with heart failure preserved ejection fraction (HFpEF) that contributes to increased morbidity and mortality. However, the impact of AF on key HFpEF physiologic features, including exercise tolerance (peak oxygen uptake, VO2peak) hemodynamic responses, peripheral extraction remains unclear. Purpose To compare VO2peak, peak hemodynamics arterio-venous difference (a-vO2diff) patients or without AF. Methods The...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome characterized by reduced peak oxygen uptake (VO2peak) secondary to central and peripheral limitations. Obesity well-established risk factor for HFpEF has garnered considerable interest as therapeutic target, particularly in the context of obese-HFpEF phenotype. However, impact obesity on VO2peak its Fick determinants remains unclear. Purpose To understand it’s individuals HFpEF. Methods...
Abstract Background While interpreting the mechanisms underlying exercise limitation in cardiopulmonary testing (CPET), oxygen pulse (O2pulse) is often assumed to be a surrogate for stroke volume (SV). However, rearranged Fick’s equation, O2pulse represents product of SV and arteriovenous difference (a-vO2diff). Consequently, exclusively as reflection can misleading, it disregards one its key determinants. Purpose To assess effort response determinants (SV a-vO2Diff) by simultaneous CPET...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, and not all patients respond well to current treatment. Identifying subgroups of HFpEF may support more personalised effective therapy. Using combined cardiopulmonary exercise testing stress echocardiography (CPETecho), the entire oxygen pathway during can be analysed an attractive way characterise pathophysiologically. Purpose To define clinically relevant phenotypes distinct outcome...
Abstract Background Remodelling of the left atrium (LA) and ventricle (LV) occurs in response to both pathological physiological stimuli, yet their interdependence is underutilised clinical practice. While LA LV volumes are typically assessed independently, atrioventricular ratio (LA/LV) may offer valuable context distinguishing from cardiac changes. Purpose To understand relationship between CRF LA/LV. Methods This study evaluated LA/LV, via echocardiography, cardiorespiratory fitness (CRF)...
A pesquisa objetiva analisar os desafios educacionais no ensino de ciências, as estratégias para superá-los e pesquisar sobre a formação continuada dos professores, à adaptação diversificação recursos didáticos promoção metodologias ativas ensino. metodologia se pauta na qualitativa revisão bibliográfica. Os resultados destacam da inicial escassez inadequação necessidade práticas pedagógicas contextualizadas com interdisciplinares docente. abordagem do estudo reforça importância como...
Esta pesquisa de revisão bibliográfica investiga o potencial da utilização recursos tecnológicos no processo aprendizagem leitura e escrita nas séries iniciais do Ensino Fundamental. Adotando uma abordagem qualitativa, estudo analisa como a integração ferramentas digitais impacta as concepções prática pedagógica formação docente, aprofundando discussão por meio análise que explora possibilidades os desafios dessa incorporação. O problema central desta reside em compreender são utilizados...
Esta pesquisa qualitativa aprofunda-se na questão da integração das tecnologias digitais no contexto educacional brasileiro, um processo marcado por desafios e perspectivas de transformação. Concentra-se análise dos obstáculos que permeiam a efetiva incorporação dessas nas escolas, com ênfase em como infraestrutura tecnológica ainda limitada as lacunas formação inicial continuada docentes exercem impacto considerável sobre dinâmica prática pedagógica. Objetiva compreender os enfrentados...
A cirurgia intrauterina é uma parte fundamental da medicina fetal, vez que, visa corrigir ou evitar a progressão das anomalias antes do nascimento. Essa revisão tem como objetivo analisar evolução, técnicas e implicações abordando suas indicações contraindicações. metodologia utilizada foi bibliográfica qualitativa, baseada em artigos publicados entre 2003 2024 disponíveis na íntegra bases PubMed, UpToDate, Google Acadêmico SciELO. Foram incluídos estudos português, inglês espanhol que...
This study aims to analyze the possibility of flexibilizing legal prohibition on adoption by foster families, in light constitutional principles, Child and Adolescent Statute (ECA), best interest child principle. Law No. 2.551/2018 prohibits families from adopting children under their care, seeking preserve temporary nature family fostering. However, this has raised social concerns, especially cases where strong emotional bonds are formed. Adopting a qualitative methodology, research reviews...
Objectives Compare final morphology of self‐expanding and balloon‐expandable prosthesis association with paravalvular regurgitation (PVR). Background PVR after transcatheter aortic valve replacement (TAVR) remains a frequent complication. A better understanding the geometry may be important to improve selection best device for each case possibly reduce rates PVR. Methods Retrospective study including patients consecutively submitted replacement: August/2007‐October/2016. Three months...
Vitamin B12 (VB12) deficiency is a common complication after total gastrectomy which may be associated with megaloblastic anemia and potentially irreversible neurologic symptoms. Intramuscular supplementation of VB12 has been considered the standard treatment, although it high costs patient discomfort.We performed prospective uncontrolled study (ACTRN12614000107628) in order to evaluate clinical laboratory efficacy long-term oral patients submitted gastrectomy. All received daily (1 mg/day)...