A5084031758- COVID-19 Clinical Research Studies
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- COVID-19 and healthcare impacts
- Muscle and Compartmental Disorders
- Oral Health Pathology and Treatment
- Pediatric health and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Sepsis Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Cardiac tumors and thrombi
- Acute Kidney Injury Research
- Vascular Malformations Diagnosis and Treatment
- Fungal Infections and Studies
- Counseling Practices and Supervision
- Vascular Malformations and Hemangiomas
- Cardiac Health and Mental Health
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Multiple Myeloma Research and Treatments
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Mast cells and histamine
Jinzhou Medical University
2025
Hunan University of Traditional Chinese Medicine
2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2025
Second Affiliated Hospital of Dalian Medical University
2024
China Pharmaceutical University
2024
Huazhong University of Science and Technology
2020-2024
Dalian Medical University
2024
Tongji Hospital
1995-2023
State Key Laboratory of Oral Diseases
2013
Sichuan University
2012-2013
Our previous salivary study had demonstrated an apparent T helper 2 (Th2)-predominance in saliva of oral lichen planus (OLP) patients and suggested a potential interleukin-4 (IL-4) as biomarker for monitoring disease severity. To further determine the consistency Th1/Th2 bias OLP, this investigated expression profile interferon-γ (IFN-γ) IL-4 serum relationship levels these cytokines with their partners. Sixty ethnic Chinese OLP (40 erythematous/ulcerative form 20 reticular form) were...
Although macrophage infiltration has been proven to increase calcified artery media in chronic kidney disease (CKD) patients, the mechanism by which macrophages are involved vascular calcification (VC) progression remains unclear. Taking advantage of miRNA-seq, RNA-seq, dual-luciferase reporter assay, qRT-PCR, and arteries from CKD patients as well mouse models, we identified that high-phosphate-stimulated macrophage-derived exosomes (Mexo-P) suppressed let-7b-5p expression VSMCs, further...
Abstract Recent studies have highlighted the role of gut microbiota in type 2 diabetes (T2D). Improving dysbiosis can be a potential strategy for prevention and management T2D. Here, this work finds that abundance Barnesiella intestinihominis is significantly decreased fecal T2D patients from 2‐independent centers. Oral treatment live B. (LBI) considerably ameliorates hyperglycemia liver metabolic disorders HFD/STZ‐induced models db/db mice. LBI‐derived acetate has similar protective effects...
The inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. However, the relationship between and cardiovascular disease (CVD) unclear. Thus, we aimed to explore association with CVD, well evaluate whether adhering healthy lifestyle could alleviate this association. We analyzed 6,164 participants aged ≥45 years who entered prospective cohort study China Longitudinal Study Health Retirement (CHARLS) 2011 2012 were followed up...
Granulomatous mastitis (GM) is a form of non-lactational breast inflammation that closely associated with autoimmune processes, however its underlying pathogenesis remains elusive. In this study, we employed single-cell RNA sequencing (scRNA-seq) to conduct comparative analysis GM lesion tissues versus normal tissues, thereby unveiling the immune profile tissues. Our investigation centered on T and NK cells, macrophages, epithelial endothelial cells. Notably, observed substantial...
Background: Quantitatively assessing host immunity remains a challenge in clinical practice.Results: Most parameters lymphocyte number, function and phenotype were correlated with age.The reference ranges of these established four age groups (children, adolescents, adults, elders).The numbers CD4 + T cells, CD8 B but not NK negatively age.However, the cells was positively expression CD28 on gradually decreased increasing their function.An opposite phenomenon observed expressions HLA-DR...
Abstract Metabolism has been reported to associate with the progression of vascular diseases. However, how calcification in chronic kidney disease (CKD) is regulated by metabolic status remains poorly understood. Using a model 5/6 nephrectomy, we demonstrated that aortic tissues CKD mice had preference for using oxidative phosphorylation (OXPHOS). Both high phosphate and human uremic serum-stimulated smooth muscle cells (VSMCs) enhanced mitochondrial respiration capacity, while glycolysis...
<b><i>Background:</i></b> The mortality rate of critically ill patients with coronavirus disease 2019 (COVID-19) was high. We aimed to assess the association between prolonged intermittent renal replacement therapy (PIRRT) and in COVID-19 undergoing invasive mechanical ventilation. <b><i>Methods:</i></b> This retrospective cohort study included all receiving ventilation February 12 March 2, 2020. All were followed until death or 28, survivors...
Abstract Background For the coronavirus disease 2019 (COVID-19), critically ill patients had a high mortality rate. We aimed to assess association between prolonged intermittent renal replacement therapy (PIRRT) and in with COVID-19 undergoing invasive mechanical ventilation. Methods In this retrospective cohort study, we included all ventilation from February 12 nd March 2 , 2020. All were followed until death or 28 th survivors for at least 30 days. Results 36 hospitalized ventilation,...
Maintenance hemodialysis (MHD) patients are highly vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Medical staff of dialysis facilities without sufficient biosecurity protection susceptible once exposed asymptomatic disease 2019 (COVID-19) patients. This study evaluated the epidemiological characteristics COVID-19 in all MHD and medical Wuhan, China.We collected morbidity mortality data from 52 centers Wuhan. Then, we analyzed symptoms signs our hospital...
Primary pulmonary intravascular large B‑cell lymphoma (IVLBCL) is a rare malignant extranodal lymphoma, and it presents symptoms similar to those of lung diseases. Diagnosis IVLBCL can be challenging often requires histopathological examination affected tissues. The present report describes 65‑year‑old female patient presenting with fever, without generalized lymph node enlargement. A CT scan revealed subpleural ground‑glass opacities in the upper lobe right lung. lactate dehydrogenase,...
By analyzing the clinical history, laboratory test indexes, and intraoperative ultrasound imaging data of patients receiving ultrasound-guided percutaneous transluminal angioplasty (UG-PTA) for first time, application value UG-PTA in treatment peripheral stenosis autogenous arteriovenous fistula (AVF) related factors affecting postoperative patency were investigated.A total 381 with dysfunction radio-cephalic AVF treated from June 2017 to September 2019. According inclusion exclusion...
Coronavirus disease 2019 is an epidemic throughout the world. The management of vascular access during currently unknown.In this multicenter cross-sectional study, we collected data from hemodialysis patients treated at 44 hospitals in Hubei 22 January to 10 March 2020. We estimated coronavirus outbreak.Of 9231 included, 5387 (58.4%) were men and 2959 (32.1%) older than 65 years. Arteriovenous fistula was predominant type access, accounting for 76.5%; 496 (5.4%) developed complications;...
Abstract Objectives Cephalic arch stenosis (CAS) is a common cause that leads to the failure of hemodialysis arteriovenous fistulas (AVFs). Patients with CAS are primarily treated fluoroscopy‐guided angioplasty. Here, seven patients de novo cephalic who underwent office‐based UG‐PTA were. Methods Retrospectively analyzed total 321 AVF dysfunction in nephrology departmnet between July 2017 and October 2018. Among them, were included this study followed up every 2 months for more than year....
Abstract M1 macrophage, characterized by the production of proinflammatory cytokines, has been reported to exert a critical role in ischemia-reperfusion (I/R)-induced acute kidney injury (AKI). Recently, increasing evidence suggests that aerobic glycolysis plays an important polarization macrophages. However, area still needs continuous studies although it developed lot. Here, we found upregulation ubiquitin-specific protease 25 (USP25), deubiquitinase, was correlated with renal function...