A5074320126- Obesity, Physical Activity, Diet
- HIV/AIDS Research and Interventions
- Nutritional Studies and Diet
- Diet and metabolism studies
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Child Nutrition and Water Access
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Birth, Development, and Health
- Global Public Health Policies and Epidemiology
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- Global Cancer Incidence and Screening
- HIV/AIDS drug development and treatment
- Vaccine Coverage and Hesitancy
- HIV/AIDS Impact and Responses
- Gestational Diabetes Research and Management
- HIV Research and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Maternal and Child Health
- Consumer Attitudes and Food Labeling
Right to Care
2018-2025
University of Pretoria
2021-2025
University of the Witwatersrand
2014-2024
Academy of Nutrition and Dietetics
2024
Sefako Makgatho Health Sciences University
2018
North-West University
2009-2017
Centre International de Recherche sur le Cancer
2014-2015
Health services for adolescents are increasingly recognised as a priority in low- and middle-income countries (LMICs). The Adolescent Youth Friendly Service (AYFS) approach has been promoted South Africa by the National Department of partners, means standardising quality adolescent health country. objective this paper is to detail evaluation AYFS against defined standards inform initiatives strengthening these services. A cross-sectional assessment was carried out 14 healthcare facilities...
Facility-based, multimonth dispensing of antiretroviral therapy (ART) for HIV could reduce burdens on patients and providers improve retention in care. We assessed whether 6-monthly ART was non-inferior to standard care 3-monthly dispensing.We did a pragmatic, cluster-randomised, unblinded, non-inferiority trial (INTERVAL) at 30 health facilities Malawi Zambia. Eligible participants were aged 18 years or older, HIV-positive, clinically stable ART. Before randomisation, (clusters) matched the...
Maternal pre-pregnancy body mass index (BMI) and subsequent gestational weight gain (GWG) are strong predictors of maternal infant outcomes; however the influence dietary patterns on BMI-specific GWG is unclear. This study identifies habitual intake in urban South African women explores their associations with first trimester BMI GWG. Habitual 538 pregnant was assessed using a quantitative food-frequency questionnaire were depicted via principle component analysis. Associations between...
The aim of this study was to investigate differences/similarities in dietary habits and eating practices between younger older, rural urban South African adolescents specific environments (home, community school) their associations with overweight obesity. Dietary habits, practices, anthropometric measurements were performed on (n = 392, mean age 13 years) 3098, 14 adolescents. Logistic regression analysis used examine the obesity risk. Differences by gender site within three identified....
Cervical cancer (CC) is the leading cause of death among female South Africans (SA). Improved access to reproductive health services following multi‐ethnic democracy in 1994, HIV epidemic, and initiation CC population‐based screening early 2000s have influenced epidemiology SA. We therefore evaluated trends age‐standardised incidence (ASIR) (1994–2009) mortality rates (ASMR) (2004–2012) using data from African National Cancer Registry Statistics Africa, respectively. Five‐year relative...
Objective Social epidemiology models suggest that socioeconomic status (SES) mobility across the life course affects blood pressure. The aim of this study was to investigate association between SES change infancy and adolescence, pressure, in young adults, impact early growth on relationship. Setting Data for were obtained from a ‘Birth Twenty’ cohort Soweto, Johannesburg, South Africa. Participants included 838 Black participants aged 18 years who had household measures at anthropometry 0,...
Abstract HIV treatment programs face challenges in identifying patients at risk for loss-to-follow-up and uncontrolled viremia. We applied predictive machine learning algorithms to anonymised, patient-level programmatic data from two districts South Africa, 2016–2018. developed patient scores outcomes: (1) visit attendance ≤ 28 days of the next scheduled clinic (2) suppression viral load (VL). Demographic, clinical, behavioral laboratory were investigated multiple models as predictor...
In this study, we compared admission incidence risk and the of mortality in Omicron BA.4/BA.5 wave to previous waves.
Background: In 2019, South Africa’s Antiretroviral Therapy (ART) Treatment Guidelines replaced efavirenz with dolutegravir in first-line ART. Setting: We assessed the impact of this national guideline change on retention and viral suppression Themba Lethu Clinical Cohort, Johannesburg, Africa. applied a regression discontinuity design prospective cohort study 1654 adults living HIV initiating ART within 12 months (±12 months) change. Methods: compared outcomes individuals presenting just...
Background Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, methodological challenges regarding pattern analyses. Methodology/Principal Findings identified from frequency questionnaires (FFQ) European Prospective Investigation into Cancer and Nutrition (EPIC) Study 24-hour dietary recall (24-HDR) data validate describe their related sources. Associations between...
The aim of this study was to identify and describe the diversity nutrient patterns how they associate with socio-demographic lifestyle factors including body mass index in rural black South African adolescents. Nutrient were identified from quantified food frequency questionnaires (QFFQ) 388 adolescents between ages 11-15 years Agincourt Health Socio-demographic Surveillance System (AHDSS). Principle Component Analysis (PCA) applied 25 nutrients derived QFFQs. Multiple linear regression...
HIV treatment and care for migrants is affected by their mobility interaction with programs health systems in different countries. To assess healthcare needs, preferences accessibility barriers of HIV-infected migrant populations high burden, borderland districts Lesotho.We selected 15 facilities accessed patient volumes three Maseru, Leribe Mafeteng. We used a mixed methods approach administering survey questionnaire to consenting infected individuals on anti-retroviral therapy (ART)...
Current World Health Organization (WHO) guidelines recommend early initiation of HIV positive patients on antiretroviral therapy (ART) irrespective their clinical or immunological status known as the test and start approach. Lesotho, like many other countries introduced this approach in 2016 a strategy to reach epidemic control. There will be rapidly growing number HIV-infected individuals initiating treatment leading practical challenges health systems such congestion, long waiting time for...
Multi-month dispensing of antiretroviral therapy (ART) has been taken to scale in many settings sub-Saharan Africa with the benefits improved client satisfaction and decreased costs. Six-month ART may further increase these benefits; however, data are lacking. Within a cluster-randomized trial three- versus six-month Malawi Zambia, we performed sub-study explore Zambian provider experiences multi-month dispensing. We conducted 18 in-depth interviews clinical officers nurses as part INTERVAL...
The prevalence of overweight and obesity is on the rise in South Africa, particularly among females living urban environments. purpose this qualitative study was to explore emic perspectives black young adult daughter mother pairs Soweto, Africa diet, physical activity, obesity-related health within their social cultural context.Purposeful sampling used recruit daughters with a normal body mass index (BMI) who have obese mothers. Individual semi-structured in-depth interviews were conducted...
Background: To assess the trend associations between South Africa's economic growth using various indicators (EGIs) with adult obesity prevalence over a specified period of time. Methods: Data for levels reported were obtained from national surveys conducted in African adults 1998, 2003 and 2012. EGIs incorporated current analysis World Bank IHS Global insight databases. Obesity is presented by gender, urbanisation level ethnicity. congruent to time points where data are available presented....
Objectives Identify factors (demographic and clinical) associated with a non-suppressed viral load (VL) of people living HIV (PLHIV) on antiretroviral therapy (ART) in Nigeria. Design Cross-sectional study. Setting Sixteen US Agency for International Development supported states Participants 585 632 PLHIV ART. Primary outcome measures VL non-suppression (defined as having at least 1000 RNA copies per mL plasma). χ 2 testing multivariable modified Poisson regression robust variance estimates...
Collection of reliable and comparable individual food consumption data is primary importance to better understand, control monitor malnutrition its related comorbidities in low- middle-income countries (LMICs), including Africa. The lack standardised dietary tools their research support infrastructure remains a major obstacle implement concerted region-specific action plans worldwide. Citing the magnitude this challenge, International Agency for Research on Cancer (IARC/WHO) launched "Global...
To report the prevalence and incidence of low-risk human papillomavirus infection (LR-HPV) anogenital warts (AGW) among women living with HIV (WLHIV) in Burkina Faso (BF) South Africa (SA), to explore HIV-related factors associated these outcomes.We enrolled 1238 WLHIV (BF = 615; SA 623) aged 25-50 years followed them at three time points (6, 12 16 months) after enrolment. Presence AGW was assessed during gynaecological examination. Cervico-vaginal swabs for enrolment month follow-up visits...
Polyvictimisation (PV) – exposure to violence across multiple contexts causes considerable morbidity and mortality among adolescents. Despite high levels of in urban disadvantaged settings, gender differences associations between PV mental health have not been well established. We analysed data from a survey with 2393 adolescents aged 15-19 years, recruited using respondent-driven sampling settings Baltimore (USA), Delhi (India), Ibadan (Nigeria), Johannesburg (South Africa) Shanghai...
ABSTRACT Introduction The Omicron BA.1/BA.2 wave in South Africa had lower hospitalisation and mortality than previous SARS-CoV-2 variants was followed by an BA.4/BA.5 wave. This study compared admission incidence risk across waves, the of wave, to Delta waves. Methods Data from Africa’s national hospital surveillance system, case linelist Electronic Vaccine System were linked analysed. Wave periods defined when country passed a weekly 30 cases/100,000 people. Mortality rates Delta,...