A5055631705- Virology and Viral Diseases
- Virus-based gene therapy research
- Rabies epidemiology and control
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- RNA Interference and Gene Delivery
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Protein Hydrolysis and Bioactive Peptides
- Antimicrobial Peptides and Activities
- CRISPR and Genetic Engineering
- Cardiac Structural Anomalies and Repair
- Microbial infections and disease research
- Fire effects on ecosystems
- Poxvirus research and outbreaks
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Biosensors and Analytical Detection
- Peptidase Inhibition and Analysis
Institute of Special Animal and Plant Sciences
2016-2024
Chinese Academy of Agricultural Sciences
2016-2024
Southern Medical University
2024
Nanfang Hospital
2024
Linyi University
2024
Shandong University
2019
Academy of Military Medical Sciences
2013-2016
Inner Mongolia Comprehensive Disease Prevention and Control Center
2016
Jilin University
2013-2014
One hundred and twenty-six blood samples were collected from healthy sheep goats in Xinjiang, China, during July 2014. Seventy-three (57.93%) bluetongue virus (BTV) serology-positive, 39 (30.95%) BTV NS1 gene-positive. strain XJ1407 was isolated the of gene-positive animals sequenced. Analysis its genome sequence suggests that is a novel serotype.
Peste des petits ruminants (PPR) is an infectious disease caused by peste virus (PPRV).While PPR mainly affects domestic goats and sheep, it also wild ungulates such as ibex, blue gazelle, although there are few reports regarding PPRV infection in animals.Between January 2015 February 2015, was found for the first time that ibexes died from Bazhou, Xinjiang, China, where a total of 38 (including young adult ibexes) were to have abnormally PPR-related issues.First, we tested presence F gene...
Three or four intramuscular doses of the inactivated human rabies virus vaccines are needed for pre- post-exposure prophylaxis in humans. This procedure has made a great contribution to prevent deaths, which bring huge economic burdens developing countries. Herein, recombinant adeno-associated serotype 9, AAV9-RABVG, harbouring RABV G gene, was generated serve as single dose vaccine candidate. The protein stably expressed 293T cells infected with AAV9-RABVG. A 2 × 1011 v.p. AAV9-RABVG...
The determination of levels rabies virus-neutralizing antibody (VNA) provides the foundation for quantitative evaluation immunity effects. traditional fluorescent virus neutralization test (FAVN) using a challenge standard (CVS)-11 strain as detection antigen and staining infected cells with fluorescein isothiocyanate (FITC)-labeled monoclonal antibody, is expensive high-quality reagents are often difficult to obtain in developing countries. Indeed, it essential establish rapid, economical,...
Aleutian disease (AD) is a common immunosuppressive in mink farms world-wide. Since the 1980s, counterimmunoelectrophoresis (CIEP) has been main detection method for infection with Mink Disease Virus (AMDV). In this study, six peptides derived from AMDV structural protein VP2 were designed, synthesized, and used as ELISA antigens to detect anti-AMDV antibodies sera of infected minks. Serum samples collected 764 minks five different provinces, analyzed by both CIEP (a gold standard) peptide...
Rabies virus (RABV) and canine distemper (CDV) both are contagious antigens in global populations cause server even lethal diseases many mammals. In this study, a replication-deficient human adenovirus 5 (Ad5)-vectored vaccine stain, rAd5-G-H, co-expressing RABV glycoprotein (G) CDV hemagglutinin (H) were constructed. The expression of G H Vero cells infected with rAd5-G-H was confirmed by indirect immunofluorescence assay (IFA). demonstrated homogeneous icosahedral morphology similar to...
Canine distemper (CD) is an acute infectious disease with high morbidity rates caused by a highly contagious pathogen (Canine Morbillivirus, also known as canine virus, CDV). CDV can infect broad range of carnivores resulting in complex clinical signs. Currently, there no effective method to treat for infections. Favipiravir (T-705), pyrazine derivative, was shown be antiviral drug against RNA viruses, acting on RNA-dependent polymerase (RdRp). However, whether the T-705 has effects...
Batai virus (BATV) is an arthropod-borne single-stranded RNA belonging to the genus Orthobunyavirus of family Bunyaviridae that primarily transmitted by mosquitoes. Methods for detecting BATV are currently limited serological surveillance, isolation, and conventional reverse transcription–polymerase chain reaction (RT-PCR) assay. In this study, we sought develop a detection assay needs no specialized equipment highly specific, sensitive, simple. We first developed optimized transcription...
Canine parvovirus (CPV-2) and feline (FPV) cause severe hemorrhagic diarrhea disease in dogs, cats, fur-bearing wildlife carnivores worldwide, continuing to pose significant threats. In this study, 140 rectal swabs were collected from 70 domestic dogs cats with clinical veterinary clinics Changchun during 2020. A total of 64.3% (45/70) 55.7% (39/70) tested positive for CPV-2 or FPV using colloidal gold strips. Amino acid (aa) sequence alignment the VP2 protein 39 36 samples revealed that...
Measles virus and canine distemper (CDV) cause lethal infections in their respective hosts characterized by severe immunosuppression. To furtherly acknowledge the attenuated mechanisms of regionally ongoing epidemic CDV isolates provide novel perspectives for designing new vaccines therapeutic drugs, a recombinant rHBF-vacH was employed with vaccine hemagglutinin (H) gene replacement reverse genetics based on an infectious cDNA clone wild-type HBF-1 strain. Interestingly, unlike previously...