A5004425451- Sphingolipid Metabolism and Signaling
- Photodynamic Therapy Research Studies
- Free Radicals and Antioxidants
- Cytokine Signaling Pathways and Interactions
- Effects of Radiation Exposure
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Chemokine receptors and signaling
- Hepatitis C virus research
- Immune Response and Inflammation
- Hormonal Regulation and Hypertension
- Hippo pathway signaling and YAP/TAZ
- Eicosanoids and Hypertension Pharmacology
- Viral-associated cancers and disorders
- Hedgehog Signaling Pathway Studies
- Medical Imaging Techniques and Applications
- Cell death mechanisms and regulation
- Eosinophilic Disorders and Syndromes
Inserm
2013-2025
Nantes Université
2011-2025
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2009-2025
Centre National de la Recherche Scientifique
2013-2025
Université d'Angers
2024-2025
Cancéropôle Grand Ouest
2021
Centre hospitalier universitaire de Québec
2016
Centre National pour la Recherche Scientifique et Technique (CNRST)
2016
Centre hospitalier de l'Université Laval
2016
Institut de Radioprotection et de Sûreté Nucléaire
2010
A previous in vitro study showed that sphingosine-1-phosphate (S1P), a ceramide antagonist, preserved endothelial cells culture from radiation-induced apoptosis. We proposed to validate the role of S1P tissue radioprotection by inhibiting acute gastrointestinal (GI) syndrome induced cell apoptosis after high dose radiation. Retro-orbital was injected mice exposed 15 Gy, dose-inducing GI within 10 days. Overall survival and on intestines sections were studied. Intestinal type targeted early...
Despite significant expression level in cancer cells, the role of angiotensin II Type 2 receptor (AT2R) progression remains poorly understood. We aimed to investigate involvement AT2R tumorigenesis, hypothesizing a tumor cell proliferation and/or angiogenesis. Two animal models were used: fibrosarcoma induced by 3-methylcholanthrene (3-MCA) FVB/N mice invalidated for (AT2R-KO) and carcinoma LL/2 cells injected C57BL/6N treated with antagonist PD123,319. Tumor growth was monitored,...
The tumor microenvironment (TME) of non-small cell lung cancer (NSCLC) is highly heterogeneous and involved in tumorigenesis resistance to therapy. Among the cells TME, endothelial are associated with latter processes through endothelial-to-mesenchymal transition (EndMT). During EndMT, (ECs) progressively lose their phenotype favor a mesenchymal phenotype, which favors production cancer-associated fibroblasts (CAFs). Our study aimed investigate consequences exposure different secretomes on...
Loss of function the guanine nucleotide binding protein RhoA blocks pre-T cell differentiation and survival indicating that this GTPase is a critical signaling molecule during early thymocyte development. Previous work has shown Rho family Rac-1 can initiate changes in actin dynamics necessary sufficient for The present data now show actions cells require but cannot substitute induce cytoskeletal Activation thus not to or absence receptor (TCR). failure activation impact on pre-TCR–mediated...
Oxidative stress is a leading cause of endothelial dysfunction. The p38 MAPK pathway plays determinant role in allowing cells to cope with oxidative and tightly regulated by balanced interaction between protein its interacting partners. By using proteomic approach, we identified nucleophosmin (NPM) as new partner HUVECs. Coimmunoprecipitation microscopic analyses confirmed the existence cytosolic (NPM)/p38 basal condition. stress, which was generated exposure 500 µM H2O2, induces rapid...
Ceramide-induced endothelial cell apoptosis boosts intestinal stem radiosensitivity. However, the molecular connection between these two cellular compartments has not been clearly elucidated. Here we report that ceramide and its related enzyme acid sphingomyelinase (ASM) are secreted by irradiated cells act as bystander factors to enhance radiotoxicity of epithelium. Ceramide isoforms ASM were acutely in blood serum wild-type mice after 15 Gy radiation dose, inducing a gastrointestinal...
Osteosarcoma (OS) and Ewing's sarcoma (ES) are the most common malignant bone tumors in children adolescents. In many cases, prognosis remains very poor. The Sonic hedgehog (SHH) signaling pathway, strongly involved development of cancers, regulate transcription via transcriptional factors Gli1-3. this context, RNAseq analysis OS ES cell lines reveals an increase some major compounds SHH cascade cells, such as factor Gli1. This leads to augmentation response Gli1 lines, demonstrating a...